Methotrexate-induced myelopathy responsive to substitution of multiple folate metabolites

Journal of Neuro-Oncology

Volumn 97, Issue 3, 2010, Pages 425-427

  Ackermann, R ^a   Semmler, A ^b   Maurer, G D ^a   Hattingen, E ^c   Fornoff, F ^c   Steinbach, J P ^a   Linnebank, M ^d  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Methotrexate; Myelopathy; Treatment

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTIBIOTIC AGENT; CAPECITABINE; CYANOCOBALAMIN; DEXAMETHASONE; DOCETAXEL; EPIRUBICIN; FOLIC ACID DERIVATIVE; FOLINATE; LACTIC ACID; METHIONINE; METHOTREXATE; PROTEIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ADULT; ALLELE; AMINO ACID METABOLISM; ARTICLE; BLOOD TOXICITY; BONE MARROW; BONE MARROW SUPPRESSION; BRAIN RADIATION; BRAIN VENTRICLE PERITONEUM SHUNT; BREAST CANCER; CANCER RECURRENCE; CANCER REGRESSION; CARCINOMATOUS MENINGITIS; CASE REPORT; CEREBROSPINAL FLUID CYTOLOGY; CERVICAL MYELOPATHY; CHEMOTHERAPY INDUCED EMESIS; DIARRHEA; DISEASE SEVERITY; DRUG CEREBROSPINAL FLUID LEVEL; DRUG MEGADOSE; DRUG RESPONSE; FECES INCONTINENCE; FEMALE; FOLATE METABOLISM; GASTROINTESTINAL TOXICITY; GENETIC ANALYSIS; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; HYDROCEPHALUS; LOW DRUG DOSE; MENINGEAL METASTASIS; METHIONINE METABOLISM; MULTIPLE CYCLE TREATMENT; NEUROTOXICITY; NEUTROPENIA; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCYTOPENIA; PROTEIN CEREBROSPINAL FLUID LEVEL; SENSORY DYSFUNCTION; SIDE EFFECT; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; THORACIC MYELOPATHY; THORACIC SPINE; THROMBOCYTE TRANSFUSION; URINE INCONTINENCE; URINE RETENTION;

ANTIMETABOLITES, ANTINEOPLASTIC; BREAST NEOPLASMS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MENINGEAL CARCINOMATOSIS; METHIONINE; METHOTREXATE; MIDDLE AGED; SPINAL CORD DISEASES; VITAMIN B COMPLEX;

EID: 77953288252     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-009-0028-9     Document Type: Article

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