Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 79, Issue 5, 2008, Pages 535-539

  Baehring, J M ^a   Fulbright, R K ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAPECITABINE; CARMOFUR; FLUOROURACIL; METHOTREXATE; 1-HEXYLCARBAMOYL-5-FLUOROURACIL; DEOXYCYTIDINE; DRUG DERIVATIVE; TEGAFUR;

ADOLESCENT; ADULT; AGED; ARTICLE; BASAL GANGLION; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORPUS CALLOSUM; DIFFUSION WEIGHTED IMAGING; FEMALE; HEMISPHERE; HUMAN; LEUKOENCEPHALOPATHY; MALE; MEDICAL LITERATURE; NEUROIMAGING; PRIORITY JOURNAL; RECIPIENT; STROKE; WHITE MATTER; BRAIN; BRAIN EDEMA; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENERGY METABOLISM; FOLLOW UP; IMAGE PROCESSING; INTRASPINAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; MULTIINFARCT DEMENTIA; MYELINATED NERVE; NEOPLASM; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; REGISTER; REMISSION;

ADULT; AGED; ANTINEOPLASTIC AGENTS; BRAIN; BRAIN EDEMA; DEMENTIA, VASCULAR; DEOXYCYTIDINE; DIFFUSION MAGNETIC RESONANCE IMAGING; ENERGY METABOLISM; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INFUSIONS, INTRAVENOUS; INJECTIONS, SPINAL; MAGNETIC RESONANCE IMAGING; MALE; METHOTREXATE; MIDDLE AGED; NEOPLASMS; NERVE FIBERS, MYELINATED; NEUROLOGIC EXAMINATION; REGISTRIES; REMISSION, SPONTANEOUS; STROKE; TEGAFUR;

EID: 42449143848     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2007.123737     Document Type: Article

References (24)

1. Haykin ME, Gorman M, van Hoff J, et al. Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity. J Neurooncol 2006;76:153-7.
2. Videnovic A, Semenov I, Chua-Adajar R, et al. Capecitabine-induced multifocal leukoencephalopathy: a report of five cases. Neurology 2005;65:1792-4.
3. Fisher MJ, Khademian ZP, Simon EM, et al. Diffusion-weighted MR imaging of early methotrexate-related neurotoxicity in children. AJNR Am J Neuroradiol 2005;26:1686-9.
4. Paakko E, Harila-Saari A, Vanionpaa L, et al. White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings. Med Pediatr Oncol 2000;35:456-61.
5. Asato R, Akiyama Y, Ito M, et al. Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate. Cancer 1992;70:1997-2004.
6. Sandoval C, Kutscher M, Jayabose S, et al. Neurotoxicity of intrathecal methotrexate: MR imaging findings. AJNR Am J Neuroradiol 2003;24:1887-90.
7. Rollins N, Winick N, Bash R, et al. Acute methotrexate neurotoxicity: findings on diffusion-weighted imaging and correlation with clinical outcome. AJNR Am J Neuroradiol 2004;25:1688-95.
8. Kuker W, Bader P, Herrlinger U, et al. Transient encephalopathy after intrathecal methotrexate chemotherapy: diffusion-weighted MRI. J Neurooncol 2005;73:47-9.
9. Ishibashi S, Nishimura H, Mizusawa H. 5-FU-induced acute leukoencephalopathy. Intern Med 2004;43:1009-10.
10. Tha KK, Terae S, Sugiura M, et al. Diffusion-weighted magnetic resonance imaging in early stage of 5-fluorouracil-induced leukoencephalopathy. Acta Neurol Scand 2002;106:379-86.
11. Fujikawa A, Tsuchiya K, Katase S, et al. Diffusion-weighted MR imaging of carmofur-induced leukoencephalopathy. Eur Radiol 2001;11:2602-6.
12. Mahoney DH Jr, Shuster JJ, Nitschke R, et al. Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy - a Pediatric Oncology Group study. J Clin Oncol 1998;16:1712-22.
13. Drachtman RA, Cole PD, Golden CB, et al. Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity. Pediatr Hematol Oncol 2002;19:319-27.
14. Yim YS, Mahoney DH Jr, Oshman DG. Hemiparesis and ischemic changes of the white matter after intrathecal therapy for children with acute lymphocytic leukemia. Cancer 1991;67:2058-61.
15. Quinn CT, Griener JC, Bottiglieri T, et al. Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer. J Clin Oncol 1997;15:2800-6.
16. Strunk T, Gottschalk S, Goepel W, et al. Subacute leukencephalopathy after low-dose intrathecal methotrexate in an adolescent heterozygous for the MTHFR C677T polymorphism. Med Pediatr Oncol 2003;40:48-50.
17. Packer RJ, Grossman RI, Belasco JB. High dose systemic methotrexate-associated acute neurologic dysfunction. Med Pediatr Oncol 1983;11:159-61.
18. Jaksic W, Veljkovic D, Pozza C, et al. Methotrexate-induced leukoencephalopathy reversed by aminophylline and high-dose folinic acid. Acta Haematol 2004;111:230-2.
19. Schaefer PW, Copen WA, Lev MH, et al. Diffusion-weighted imaging in acute stroke. Neuroimaging Clin N Am 2005;15:503-x.
20. Okeda R, Karakama T, Kimura S, et al. Neuropathologic study on chronic neurotoxicity of 5-fluorouracil and its masked compounds in dogs. Acta Neuropathol (Berl) 1984;63:334-43.
21. Okeda R, Shibutani M, Matsuo T, et al. Experimental neurotoxicity of 5-fluorouracil and its derivatives is due to poisoning by the monofluorinated organic metabolites, monofluoroacetic acid and alpha-fluoro-beta-alanine. Acta Neuropathol (Berl) 1990;81:66-73.
22. Akiba T, Okeda R, Tajima T. Metabolites of 5-fluorouracil, alpha-fluoro-beta-alanine and fluoroacetic acid, directly injure myelinated fibers in tissue culture. Acta Neuropathol (Berl) 1996;92:8-13.
23. Wolters EC, van Wijngaarden GK, Stam FC, et al. Leucoencephalopathy after inhaling "heroin" pyrolysate. Lancet 1982;2:1233-7.
24. Chen CY, Lee KW, Lee CC, et al. Heroin-induced spongiform leukoencephalopathy: value of diffusion MR imaging. J Comput Assist Tomogr 2000;24:735-7.