Label-free biosensor arrays based on silicon ring resonators and high-speed optical scanning instrumentation

IEEE Journal on Selected Topics in Quantum Electronics

Volumn 16, Issue 3, 2010, Pages 654-661

  Iqbal, Muzammil ^a   Gleeson, Martin A ^a   Spaugh, Bradley ^a   Tybor, Frank ^a   Gunn, William G ^a   Hochberg, Michael ^b   Baehr Jones, Tom ^b   Bailey, Ryan C ^c   Gunn, L Cary ^a  

^a Genalyte Inc   (United States)

^b University of Washington   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Optical biosensing; Refractometric sensor; Resonant cavity sensors; Ring resonator sensor

Indexed keywords

OPTICAL BIO-SENSING; REFRACTOMETRIC SENSORS; RESONANT CAVITY; RESONANT CAVITY SENSORS; RING RESONATOR;

BIOSENSORS; BODY FLUIDS; CAVITY RESONATORS; OLIGONUCLEOTIDES; REFRACTIVE INDEX; SENSOR ARRAYS;

OPTICAL RESONATORS;

EID: 77953287904     PISSN: 1077260X     EISSN: None     Source Type: Journal    
DOI: 10.1109/JSTQE.2009.2032510     Document Type: Article

References (29)

1. F. Mitschke, "Fiber-optic sensor for humidity," OSA Opt. Lett., vol.14, pp. 967-969, 1989.
2. G. Mitchell, "A review of Fabry-Perot interferometer sensors," in Proc. Phys., vol.44, pp. 450-457, 1989.
3. K.Murphy, M. Gunther, A. Vengsarkar, and R. Claus, "Quadrature phaseshifted, extrinsic Fabry-Perot optical fiber sensors," OSA Opt. Lett., vol.16, pp. 273-275, 1991.
4. A. Brandenburg, R. Edelhauser, and F. Hutter, "Gas sensor based on an intergrated optical interferometer," SPIE Chem. Med. Sens., vol.1510, pp. 148-159, 1991.
5. P. Lambeck, "Integrated opto-chemical sensors," Sens. Actuators B, Chem., vol.8, pp. 103-116, 1992.
6. M. Emsley, O. Dounmu, andM. Unlu, "Silicon substrates with buried distributed Bragg reflectors for resonant cavity-enhanced optoelectronics," IEEE J. Sel. Top. Quantum Electron., vol.8, no.4, pp. 948-955, Jul./Aug. 2002.
7. S. Arnold, M. Khoshima, I. Teraoka, S. Holler, and F. Vollmer, "Shift of whispering-gallery modes in microspheres by protein adsorption," OSA Opt. Lett., vol.28, pp. 272-274, 2003.
8. N. Hanumegowda, C. Stica, B. Patel, I. White, and X. Fan, "Refractometric sensors based on microsphere resonators," Apl. Phys. Lett., vol.87, pp. 201107-1-201107-3, 2005.
9. R. Boyd and J. Heebner, "Sensitive disk resonator photonic biosensor," OSA Appl. Opt., vol.40, pp. 5742-5747, 2001.
10. E. Krioukov, D. Klunder, A. Driessen, C. Otto, and J. Greve, "Refractive index sensing using an integrated optical microcavity," OSA Opt. Lett., vol.27, pp. 512-514, 2002.
11. A. Armani, R. Kulkarni, S. Fraser, R. Flagan, and K. Vahala, "Label-free, single-molecule detection with optical microcavities," Science, vol.213, pp. 783-787, 2007.
12. E. Chow, A. Grot, L. Mirkarimi, M. Sigalas, and G. Girolami, "Ultracompact biochemical sensor built with two-dimensional photonic crystal microcavity," OSA Opt. lett., vol.29, pp. 1093-1095, 2004.
13. A. Ksendzov and Y. Lin, "Integrated optics ring-resonator sensor for protein detection," OSA Opt. Lett., vol.30, pp. 3344-3346, 2005.
14. K. D. Vos, I. Bartolozi, E. Schacht, P. Bienstman, and R. Baets, "Siliconon- insulator microring resonator for sensitive and label-free biosensing," OSA Opt. Exp., vol.15, pp. 7610-7615, 2007.
15. M. Kwon andW. Steir, "Micoring-resonator-based sensor measuring both the concentration and temperature of a solution," OSA Opt. Exp., vol.16, pp. 9372-9377, 2008.
16. A. Ramachandran, S. Wang, J. Clarke, S. Ja, D. Goad, L. Wald, E. Flood, E. Knobbe, J.Hryniewicz, S. Chu, D. Gill,W. Chen,O.King, and B. Little, "A universal biosensing platform based on optical micro-ring resonators," Biosens. Bioelectron., vol.23, pp. 939-944, 2008.
17. A. Yalcin, K. C. Popat, J. C. Aldridge, T. A. Desai, J. Hryniewicz, N. Chbouki, B. E. Little, V. Oliver King Van, D. S. C. Gill, M. Anthes- Washburn, M. S. Unlu, and B. B. Goldberg, "Optical sensing of biomolecules using microring resonator," IEEE J. Sel. Topics Quantum Electron., vol.12, no.1, pp. 148-155, Jan./Feb. 2006.
18. A. L.Washburn, L. C. Gunn, and R. C. Bailey, "Label-free quantitation of a cancer biomarker in complex media using silicon photonics microring resonators," Amer. Chem. Soc., Anal. Chem. J., vol.81, pp. 9499-9506, 2009.
19. A. Yariv, "Universal relations for coupling of optical power between microresonators and dielectric waveguides," Electron. Lett., vol.36, no.4, pp. 321-322, Feb. 2000.
20. ePIXnet-European network for excellence on photonic integrated components and circuits. Available: www.epixnet.org
21. P. Dumon, W. Bogaerts, A. Tchelnokov, J.-M. Fdedli, and R. Baets, "Silicon nanophotonics," Future Fabs Int., vol.25, pp. 29-36, 2008.
22. D. Taillaert, W. Bogaerts, P. Bienstman, T. Krauss, P. Daele, I. Moerman, S. Verstuyft, K. De Mesel, and R. Baets, "An out-of-plane grating coupler for efficient butt-coupling between compact planarwaveguides and singlemode fibers," IEEE J. Quantum Electron., vol.38, no.7, pp. 949-955, Jul. 2002.
23. F. Laere, G. Roelkens, M. Ayre, J. Schrauwen, D. Taillaert, D. Thourhout, T. Krauss, and R. Baets, "Compact and highly efficient grating coupers between optical fiber and nanophotonic wavegudes," J. Lightw. Technol., vol.25, no.1, pp. 151-156, Jan. 2007.
24. X. Quan and E. Fry, "Empirical equation for the index of refraction of seawater," OSA Appl. Opt., vol.34, pp. 3477-3480, 1995.
25. D. Kurth and T. Bein, "Surface reaction on thin layers of silane coupling agents," Amer. Chem. Soc., vol.9, pp. 2965-2973, 1993.
26. R. Greenfield, T. Kaneko, A. Daues, M. Edson, K. Fitzgerald, L. Olech, J. Grattan, and G. Braslawsky, "Evaluation in vitro of adriamycin immunoconjugates synthesized using an acid-sensitive hydrazone linker," Cancer Res., vol.50, pp. 6600-6607, 1990.
27. B. Johnsson, S. Lofas, and G. Lindquist, "Immobilization of proteins to a corboxymethldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors," Anal. Biochem. Soc., vol.198, pp. 268-277, 1991.
28. V. Prez-Luna,M. O'Brien, K. Opperman, P. Hampton, G. Lpez, L. Klumb, and P. Stayton, "Molecular recognition between genetically engineered streptavidin and surface-bound biotin," J. M. Chem. Soc., vol.27, pp. 6469-6478, 1999.
29. A. Qavi, A. Washburn, J.-Y. Byeon, and R. Bailey, "Label-free technologies for quantitative multiparameter biological analysis," Anal. Bioanalytical Chem., vol.394, pp. 121-135, 2009.