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Volumn 115, Issue 20, 2010, Pages 4061-4070

Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; ANAPLASTIC LYMPHOMA KINASE; DOXYCYCLINE; NUCLEOPHOSMIN; TROPOMYOSIN; CRE RECOMBINASE; INTEGRASE; MESSENGER RNA; P80(NPM ALK) PROTEIN; P80(NPM-ALK) PROTEIN; PROTEIN TYROSINE KINASE; TPM3 PROTEIN, HUMAN;

EID: 77953265187     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-06-163386     Document Type: Article
Times cited : (30)

References (50)
  • 1
    • 0028198206 scopus 로고
    • Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
    • Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science. 1994;263(5151):1281-1284.
    • (1994) Science , vol.263 , Issue.5151 , pp. 1281-1284
    • Morris, S.W.1    Kirstein, M.N.2    Valentine, M.B.3
  • 2
    • 0033134786 scopus 로고    scopus 로고
    • A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1; 2)(q25;p23) translocation
    • Lamant L, Dastugue N, Pulford K, Delsol G, Mariame B. A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1; 2)(q25;p23) translocation. Blood. 1999;93(9):3088-3095.
    • (1999) Blood , vol.93 , Issue.9 , pp. 3088-3095
    • Lamant, L.1    Dastugue, N.2    Pulford, K.3    Delsol, G.4    Mariame, B.5
  • 3
    • 0034658434 scopus 로고    scopus 로고
    • Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like)
    • Touriol C, Greenland C, Lamant L, et al. Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like). Blood. 2000;95(10):3204-3207.
    • (2000) Blood , vol.95 , Issue.10 , pp. 3204-3207
    • Touriol, C.1    Greenland, C.2    Lamant, L.3
  • 4
    • 0038122781 scopus 로고    scopus 로고
    • Non-muscle myosin heavy chain (MYH9): A new partner fused to ALK in anaplastic large cell lymphoma
    • Lamant L, Gascoyne RD, Duplantier MM, et al. Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma. Genes Chromosomes Cancer. 2003;37(4):427-432.
    • (2003) Genes Chromosomes Cancer , vol.37 , Issue.4 , pp. 427-432
    • Lamant, L.1    Gascoyne, R.D.2    Duplantier, M.M.3
  • 5
    • 12144258439 scopus 로고    scopus 로고
    • The emerging normal and disease-related roles of anaplastic lymphoma kinase
    • Pulford K, Lamant L, Espinos E, et al. The emerging normal and disease-related roles of anaplastic lymphoma kinase. Cell Mol Life Sci. 2004;61(23):2939-2953.
    • (2004) Cell Mol Life Sci , vol.61 , Issue.23 , pp. 2939-2953
    • Pulford, K.1    Lamant, L.2    Espinos, E.3
  • 8
    • 19244366885 scopus 로고    scopus 로고
    • A new subtype of large B-cell lymphoma expressing the ALK kinase and lacking the 2; 5 translocation
    • Delsol G, Lamant L, Mariame B, et al. A new subtype of large B-cell lymphoma expressing the ALK kinase and lacking the 2; 5 translocation. Blood. 1997;89(5):1483-1490.
    • (1997) Blood , vol.89 , Issue.5 , pp. 1483-1490
    • Delsol, G.1    Lamant, L.2    Mariame, B.3
  • 9
    • 0141705308 scopus 로고    scopus 로고
    • ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: Report of 6 cases
    • Gascoyne RD, Lamant L, Martin-Subero JI, et al. ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases. Blood. 2003;102(7):2568-2573.
    • (2003) Blood , vol.102 , Issue.7 , pp. 2568-2573
    • Gascoyne, R.D.1    Lamant, L.2    Martin-Subero, J.I.3
  • 10
    • 0142200927 scopus 로고    scopus 로고
    • A case of a diffuse large B-cell lymphoma of plasmablastic type associated with the t(2;5)(p23;q35) chromosome translocation
    • Adam P, Katzenberger T, Seeberger H, et al. A case of a diffuse large B-cell lymphoma of plasmablastic type associated with the t(2;5)(p23;q35) chromosome translocation. Am J Surg Pathol. 2003;27(11):1473-1476.
    • (2003) Am J Surg Pathol , vol.27 , Issue.11 , pp. 1473-1476
    • Adam, P.1    Katzenberger, T.2    Seeberger, H.3
  • 11
    • 0141593498 scopus 로고    scopus 로고
    • ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: Report of 2 cases
    • Onciu M, Behm FG, Downing JR, et al. ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases. Blood. 2003;102(7):2642-2644.
    • (2003) Blood , vol.102 , Issue.7 , pp. 2642-2644
    • Onciu, M.1    Behm, F.G.2    Downing, J.R.3
  • 12
    • 4444319567 scopus 로고    scopus 로고
    • Differential effects of x-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells
    • Armstrong F, Duplantier MM, Trempat P, et al. Differential effects of x-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells. Oncogene. 2004;23(36):6071-6082.
    • (2004) Oncogene , vol.23 , Issue.36 , pp. 6071-6082
    • Armstrong, F.1    Duplantier, M.M.2    Trempat, P.3
  • 13
    • 0030934862 scopus 로고    scopus 로고
    • Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis
    • Bischof D, Pulford K, Mason DY, Morris SW. Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis. Mol Cell Biol. 1997;17(4):2312-2325.
    • (1997) Mol Cell Biol , vol.17 , Issue.4 , pp. 2312-2325
    • Bischof, D.1    Pulford, K.2    Mason, D.Y.3    Morris, S.W.4
  • 14
    • 0030003813 scopus 로고    scopus 로고
    • Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
    • Fujimoto J, Shiota M, Iwahara T, et al. Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5). Proc Natl Acad Sci U S A. 1996;93(9):4181-4186.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.9 , pp. 4181-4186
    • Fujimoto, J.1    Shiota, M.2    Iwahara, T.3
  • 15
    • 0030754799 scopus 로고    scopus 로고
    • The activated anaplastic lymphoma kinase increases cellular proliferation and oncogene up-regulation in rat 1a fibroblasts
    • Wellmann A, Doseeva V, Butscher W, et al. The activated anaplastic lymphoma kinase increases cellular proliferation and oncogene up-regulation in rat 1a fibroblasts. FASEB J. 1997;11(12):965-972.
    • (1997) FASEB J , vol.11 , Issue.12 , pp. 965-972
    • Wellmann, A.1    Doseeva, V.2    Butscher, W.3
  • 16
    • 33846110366 scopus 로고    scopus 로고
    • Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK
    • Galkin AV, Melnick JS, Kim S, et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007;104(1):270-275.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.1 , pp. 270-275
    • Galkin, A.V.1    Melnick, J.S.2    Kim, S.3
  • 17
    • 39749181662 scopus 로고    scopus 로고
    • Development of a conditional bioluminescent transplant model for TPM3-ALK-induced tumorigenesis as a tool to validate ALK-dependent cancer targeted therapy
    • Giuriato S, Faumont N, Bousquet E, et al. Development of a conditional bioluminescent transplant model for TPM3-ALK-induced tumorigenesis as a tool to validate ALK-dependent cancer targeted therapy. Cancer Biol Ther. 2007;6(8):1318-1323.
    • (2007) Cancer Biol Ther , vol.6 , Issue.8 , pp. 1318-1323
    • Giuriato, S.1    Faumont, N.2    Bousquet, E.3
  • 18
    • 0030809095 scopus 로고    scopus 로고
    • Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice
    • Kuefer MU, Look AT, Pulford K, et al. Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice. Blood. 1997;90(8):2901-2910.
    • (1997) Blood , vol.90 , Issue.8 , pp. 2901-2910
    • Kuefer, M.U.1    Look, A.T.2    Pulford, K.3
  • 19
    • 0043091984 scopus 로고    scopus 로고
    • The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model
    • Miething C, Grundler R, Fend F, et al. The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model. Oncogene. 2003;22(30):4642-4647.
    • (2003) Oncogene , vol.22 , Issue.30 , pp. 4642-4647
    • Miething, C.1    Grundler, R.2    Fend, F.3
  • 20
    • 0037372285 scopus 로고    scopus 로고
    • NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors
    • Chiarle R, Gong JZ, Guasparri I, et al. NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors. Blood. 2003;101(5):1919-1927.
    • (2003) Blood , vol.101 , Issue.5 , pp. 1919-1927
    • Chiarle, R.1    Gong, J.Z.2    Guasparri, I.3
  • 21
    • 23344438812 scopus 로고    scopus 로고
    • Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas
    • Jager R, Hahne J, Jacob A, et al. Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas. Anticancer Res. 2005;25(5):3191-3196.
    • (2005) Anticancer Res , vol.25 , Issue.5 , pp. 3191-3196
    • Jager, R.1    Hahne, J.2    Jacob, A.3
  • 22
    • 33749440600 scopus 로고    scopus 로고
    • Targeting the oncogenic tyrosine kinase NPM-ALK in lymphoma: The role of murine models in defining pathogenesis and treatment options
    • Miething C, Peschel C, Duyster J. Targeting the oncogenic tyrosine kinase NPM-ALK in lymphoma: the role of murine models in defining pathogenesis and treatment options. Curr Drug Targets. 2006;7(10):1329-1334.
    • (2006) Curr Drug Targets , vol.7 , Issue.10 , pp. 1329-1334
    • Miething, C.1    Peschel, C.2    Duyster, J.3
  • 23
    • 21744438972 scopus 로고    scopus 로고
    • What have we learnt from mouse models of NPM-ALK-induced lymphomagenesis?
    • Turner SD, Alexander DR. What have we learnt from mouse models of NPM-ALK-induced lymphomagenesis? Leukemia. 2005;19(7):1128-1134.
    • (2005) Leukemia , vol.19 , Issue.7 , pp. 1128-1134
    • Turner, S.D.1    Alexander, D.R.2
  • 24
    • 0742287062 scopus 로고    scopus 로고
    • Conditional animal models: A strategy to define when oncogenes will be effective targets to treat cancer
    • Giuriato S, Rabin K, Fan AC, Shachaf CM, Felsher DW. Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer. Semin Cancer Biol. 2004;14(1):3-11.
    • (2004) Semin Cancer Biol , vol.14 , Issue.1 , pp. 3-11
    • Giuriato, S.1    Rabin, K.2    Fan, A.C.3    Shachaf, C.M.4    Felsher, D.W.5
  • 25
    • 0025906674 scopus 로고
    • Transgenic models for haemopoietic malignancies
    • Adams JM, Cory S. Transgenic models for haemopoietic malignancies. Biochim Biophys Acta. 1991;1072(1):9-31.
    • (1991) Biochim Biophys Acta , vol.1072 , Issue.1 , pp. 9-31
    • Adams, J.M.1    Cory, S.2
  • 26
    • 0033180211 scopus 로고    scopus 로고
    • Reversible tumorigenesis by MYC in hematopoietic lineages
    • Felsher DW, Bishop JM. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell. 1999;4(2):199-207.
    • (1999) Mol Cell , vol.4 , Issue.2 , pp. 199-207
    • Felsher, D.W.1    Bishop, J.M.2
  • 27
    • 0031689795 scopus 로고    scopus 로고
    • ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum
    • Falini B, Bigerna B, Fizzotti M, et al. ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum. Am J Pathol. 1998;153(3):875-886.
    • (1998) Am J Pathol , vol.153 , Issue.3 , pp. 875-886
    • Falini, B.1    Bigerna, B.2    Fizzotti, M.3
  • 28
    • 33646540436 scopus 로고    scopus 로고
    • SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling
    • Honorat JF, Ragab A, Lamant L, Delsol G, Ragab-Thomas J. SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling. Blood. 2006;107(10):4130-4138.
    • (2006) Blood , vol.107 , Issue.10 , pp. 4130-4138
    • Honorat, J.F.1    Ragab, A.2    Lamant, L.3    Delsol, G.4    Ragab-Thomas, J.5
  • 29
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A. 1992;89(12):5547-5551.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.12 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 30
    • 0029075822 scopus 로고
    • Coregulation of two gene activities by tetracycline via a bidirectional promoter
    • Baron U, Freundlieb S, Gossen M, Bujard H. Coregulation of two gene activities by tetracycline via a bidirectional promoter. Nucleic Acids Res. 1995;23(17):3605-3606.
    • (1995) Nucleic Acids Res , vol.23 , Issue.17 , pp. 3605-3606
    • Baron, U.1    Freundlieb, S.2    Gossen, M.3    Bujard, H.4
  • 31
    • 0023118719 scopus 로고
    • Expression of the c-myc oncogene under control of an immunoglobulin enhancer in e mu-myc transgenic mice
    • Alexander WS, Schrader JW, Adams JM. Expression of the c-myc oncogene under control of an immunoglobulin enhancer in E mu-myc transgenic mice. Mol Cell Biol. 1987;7(4):1436-1444.
    • (1987) Mol Cell Biol , vol.7 , Issue.4 , pp. 1436-1444
    • Alexander, W.S.1    Schrader, J.W.2    Adams, J.M.3
  • 33
    • 34447300172 scopus 로고    scopus 로고
    • Flow cytometric detection of circulating tumour cells in nucleophosmin/anaplastic lymphoma kinase-positive anaplastic large cell lymphoma: Comparison with quantitative polymerase chain reaction
    • Damm-Welk C, Schieferstein J, Schwalm S, Reiter A, Woessmann W. Flow cytometric detection of circulating tumour cells in nucleophosmin/anaplastic lymphoma kinase-positive anaplastic large cell lymphoma: comparison with quantitative polymerase chain reaction. Br J Haematol. 2007;138(4):459-466.
    • (2007) Br J Haematol , vol.138 , Issue.4 , pp. 459-466
    • Damm-Welk, C.1    Schieferstein, J.2    Schwalm, S.3    Reiter, A.4    Woessmann, W.5
  • 34
    • 0031907808 scopus 로고    scopus 로고
    • Murine B lymphopoiesis: Towards a unified model
    • Osmond DG, Rolink A, Melchers F. Murine B lymphopoiesis: towards a unified model. Immunol Today. 1998;19(2):65-68.
    • (1998) Immunol Today , vol.19 , Issue.2 , pp. 65-68
    • Osmond, D.G.1    Rolink, A.2    Melchers, F.3
  • 35
    • 37549059613 scopus 로고    scopus 로고
    • Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
    • Christensen JG, Zou HY, Arango ME, et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther. 2007;6(12):3314-3322.
    • (2007) Mol Cancer Ther , vol.6 , Issue.12 , pp. 3314-3322
    • Christensen, J.G.1    Zou, H.Y.2    Arango, M.E.3
  • 36
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007;131(6):1190-1203.
    • (2007) Cell , vol.131 , Issue.6 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3
  • 37
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561- 566.
    • (2007) Nature , vol.448 , Issue.7153 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 38
    • 0344441893 scopus 로고    scopus 로고
    • Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase
    • Turner SD, Tooze R, Maclennan K, Alexander DR. Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase. Oncogene. 2003;22(49):7750-7761.
    • (2003) Oncogene , vol.22 , Issue.49 , pp. 7750-7761
    • Turner, S.D.1    Tooze, R.2    Maclennan, K.3    Alexander, D.R.4
  • 39
    • 33750727669 scopus 로고    scopus 로고
    • CD2 promoter regulated nucleophosmin-anaplastic lymphoma kinase in transgenic mice causes B lymphoid malignancy
    • Turner SD, Merz H, Yeung D, Alexander DR. CD2 promoter regulated nucleophosmin-anaplastic lymphoma kinase in transgenic mice causes B lymphoid malignancy. Anticancer Res. 2006;26(5A):3275-3279.
    • (2006) Anticancer Res , vol.26 , Issue.5 A , pp. 3275-3279
    • Turner, S.D.1    Merz, H.2    Yeung, D.3    Alexander, D.R.4
  • 40
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams JM, Harris AW, Pinkert CA, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985;318(6046):533-538.
    • (1985) Nature , vol.318 , Issue.6046 , pp. 533-538
    • Adams, J.M.1    Harris, A.W.2    Pinkert, C.A.3
  • 41
    • 0842264007 scopus 로고    scopus 로고
    • E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia
    • Greenwald RJ, Tumang JR, Sinha A, et al. E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. Blood. 2004;103(4):1475-1484.
    • (2004) Blood , vol.103 , Issue.4 , pp. 1475-1484
    • Greenwald, R.J.1    Tumang, J.R.2    Sinha, A.3
  • 42
    • 0023022625 scopus 로고
    • The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice
    • Langdon WY, Harris AW, Cory S, Adams JM. The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell. 1986;47(1):11-18.
    • (1986) Cell , vol.47 , Issue.1 , pp. 11-18
    • Langdon, W.Y.1    Harris, A.W.2    Cory, S.3    Adams, J.M.4
  • 43
    • 27444435678 scopus 로고    scopus 로고
    • Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax
    • Kwon H, Ogle L, Benitez B, et al. Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax. J Biol Chem. 2005;280(42):35713-35722.
    • (2005) J Biol Chem , vol.280 , Issue.42 , pp. 35713-35722
    • Kwon, H.1    Ogle, L.2    Benitez, B.3
  • 44
    • 0038387495 scopus 로고    scopus 로고
    • Opinion: Cancer revoked: oncogenes as therapeutic targets
    • Felsher DW. Opinion: cancer revoked: oncogenes as therapeutic targets. Nat Rev Cancer. 2003;3(5):375-379.
    • (2003) Nat Rev Cancer , vol.3 , Issue.5 , pp. 375-379
    • Felsher, D.W.1
  • 45
    • 33845645365 scopus 로고    scopus 로고
    • Oncogenic shock: Turning an activated kinase against the tumor cell
    • Sharma SV, Settleman J. Oncogenic shock: turning an activated kinase against the tumor cell. Cell Cycle. 2006;5(24):2878-2880.
    • (2006) Cell Cycle , vol.5 , Issue.24 , pp. 2878-2880
    • Sharma, S.V.1    Settleman, J.2
  • 46
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes - The Achilles heal of cancer
    • Weinstein IB. Cancer. Addiction to oncogenes - the Achilles heal of cancer. Science. 2002;297(5578):63-64.
    • (2002) Science , vol.297 , Issue.5578 , pp. 63-64
    • Weinstein, I.B.1
  • 47
    • 8844219643 scopus 로고    scopus 로고
    • Centrosome abnormalities in ALK-positive anaplastic large-cell lymphoma
    • Ventura RA, Martin-Subero JI, Knippschild U, et al. Centrosome abnormalities in ALK-positive anaplastic large-cell lymphoma. Leukemia. 2004;18(11):1910-1911.
    • (2004) Leukemia , vol.18 , Issue.11 , pp. 1910-1911
    • Ventura, R.A.1    Martin-Subero, J.I.2    Knippschild, U.3
  • 48
    • 38949116321 scopus 로고    scopus 로고
    • Genomic profiling reveals different genetic aberrations in systemic ALK-positive and ALK-negative anaplastic large cell lymphomas
    • Salaverria I, Bea S, Lopez-Guillermo A, et al. Genomic profiling reveals different genetic aberrations in systemic ALK-positive and ALK-negative anaplastic large cell lymphomas. Br J Haematol. 2008;140(5):516-526.
    • (2008) Br J Haematol , vol.140 , Issue.5 , pp. 516-526
    • Salaverria, I.1    Bea, S.2    Lopez-Guillermo, A.3
  • 49
    • 42549119526 scopus 로고    scopus 로고
    • Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy
    • Li R, Morris SW. Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy. Med Res Rev. 2008;28(3):372-412.
    • (2008) Med Res Rev , vol.28 , Issue.3 , pp. 372-412
    • Li, R.1    Morris, S.W.2
  • 50
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344(14):1031-1037.
    • (2001) N Engl J Med , vol.344 , Issue.14 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3


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