Effect of robo1 on retinal pigment epithelial cells and experimental proliferative vitreoretinopathy

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 6, 2010, Pages 3193-3204

  Huang, Lvzhen ^a   Xu, Yongsheng ^a   Yu, Wenzhen ^a   Li, Yingjie ^b   Chu, Liqun ^a   Dong, Jianqiang ^a   Li, Xiaoxin ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN; PROTEIN ROBO1; ROUNDABOUT RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; CD31 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN RECEPTOR; KERATIN; NERVE PROTEIN;

ADULT; AGED; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL SPREADING; CELL SURVIVAL; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GLIA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RETINA DETACHMENT; VASCULAR ENDOTHELIUM; VITREORETINOPATHY; ADOLESCENT; ANIMAL; CELL LINE; CELL MOTION; CHILD; DIABETIC RETINOPATHY; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIRETINAL MEMBRANE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE SILENCING; GENETICS; GLIA; METABOLISM; MIDDLE AGED; PHYSIOLOGY; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; AGED; ANIMALS; ANTIGENS, CD31; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CHILD; DIABETIC RETINOPATHY; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIRETINAL MEMBRANE; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE SILENCING; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; KERATINS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROGLIA; RABBITS; RECEPTORS, IMMUNOLOGIC; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; VITREORETINOPATHY, PROLIFERATIVE; YOUNG ADULT;

EID: 77953264311     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3779     Document Type: Article

References (47)

1. Gilbert C, Hiscott P, Unger W, et al. Inflammation and the formation of epiretinal membranes. Eye. 1988;2:S140-S156.
2. Garner A. Histopathology of diabetic retinopathy in man. Eye. 1993;7:250-253.
3. Grierson I, Mazure A, Hogg P, et al. Non-vascular vitreoretinopathy: the cells and the cellular basis of contraction. Eye. 1996;10:671-684.
4. Lahey JM, Francis RR, Kearney JJ. Combining phacoemulsification with pars plana vitrectomy in patients with proliferative diabetic retinopathy: a series of 223 cases. Ophthalmology. 2003;110: 1335-1339.
5. Schmidt JC, Rodrigues EB, Hoerle S, et al. Primary vitrectomy in complicated rhegmatogenous retinal detachment: a survey of 205 eyes. Ophthalmologica. 2003;217:387-392.
6. Weinberg DV, Lyon AT, Greenwald MJ, et al. Rhegmatogenous retinal detachments in children: risk factors and surgical outcomes. Ophthalmology. 2003;110:1708-1713.
7. Seeger M, Tear G, Ferres-Marco D, et al. Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron. 1993;10:409-426.
8. Long H, Sabatier C, Ma L, et al. Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron. 2004;42: 213-223.
9. Løes S, Luukko K, Kvinnsland IH, et al. Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation. Mech Dev. 2001;107:155-157.
10. Yuan W, Zhou L, Chen JH, et al. The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev Biol. 1999;212:290-306.
11. Erskine L, Williams SE, Brose K, et al. Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of Robos and Slits. J Neurosci. 2000;20:4975-4982.
12. Piper M, Nurcombe V, Wilkinson L, et al. Exogenous Slit2 does not affect ureteric branching or nephron formation during kidney development. Int J Dev Biol. 2002;46:545-550.
13. Wu JY, Feng L, Park HT, et al. The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature. 2001;410:948-952.
14. Niclou SP, Jia L, Raper JA. Slit2 is a repellent for retinal ganglion cell axons. JNeurosci. 2000;20:4962-4974.
15. Ringstedt T, Braisted JE, Brose K, et al. Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns in the diencephalon. J Neurosci. 2000;20:4983-4991
16. Xian J, Aitchison A, Bobrow L, et al. Targeted disruption of the 3p12 gene, DUTT1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter. Cancer Res. 2004;64:6432-6437.
17. Petek E, Windpassinger C, Simma B, et al. Molecular characterisation of a 15 Mb constitutional de novo interstitial deletion of chromosome 3p in a boy with developmental delay and congenital anomalies. J Hum Genet. 2003;48:283-287.
18. Ito H, Funahashi S, Yamauchi N, et al. Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target. Clin Cancer Res. 2006;12:3257-3264.
19. Grone J, Doebler O, Loddenkemper C, et al. Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. Oncol Rep. 2006;15:1437-1443.
20. Wang B, Xiao Y, Ding BB, et al. Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell. 2003;4:19-29
21. Clark K, Hammond E, Rabbitts P, et al. Temporal and spatial expression of two isoforms of the Dutt1/Robo1 gene in mouse development. FEBS Lett. 2002;523:12-16.
22. Huang LZ, Yu WZ, Li XX et al. Robo1/Robo4: different expression pattern in the retinal development. Exp Eye Res. 2009;88:583-588.
23. Zhou P, Zhao MW, Li XX, et al. siRNA targeting mammalian target of rapamycin (mTOR) attenuates experimental proliferative vitreo-retinopathy. Curr Eye Res. 2007;32:973-984.
24. Chen Y, Li XX, Xing NZ, et al. Quercetin inhibits choroidal and retinal angiogenesis in vitro. Graefes Arch Clin Exp Ophthalmol 2008;246:373-378.
25. Masson-Gadais B, Salers P, Bongrand P, et al. PKC regulation of microfilament network organization in keratinocytes defined by a pharmacological study with PKC activators and inhibitors. Exp Cell Res. 1997;236:238-247.
26. Eibl KH, Kook D, Priglinger S, et al. Inhibition of human retinal pigment epithelial cell attachment, spreading, and migration by Alkylphosphocholines. Invest Ophthalmol Vis Sci. 2006;47:364-370.
27. Bagli E, Stefaniotou M, Morbidelli L, et al. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidyl-inositol 3'-kinase activity. Cancer Res. 2004;64:7936-7946.
28. Fastenberg DM, Diddie KR, Dorey K, et al. The role of cellular proliferation in an experimental model of massive periretinal proliferation. Am J Ophthalmol. 1982;93:565-572.
29. Wang LJ, Zhao Y, Han B, et al. Targeting Slit-Roundabout signaling inhibits tumor angiogenesis in chemical-induced squamous cell carcinogenesis. Cancer Sci. 2008;99:510-517.
30. Hui YH, Goodnight R, Zhang XJ et al. Glial epiretinal membranes and contraction. Immunohistochemical and morphological studies. Arch Ophthalmol. 1988;106:1280-1285.
31. Bicknell R, Harris AL. Novel angiogenic signaling pathways and vascular targets. Annu Rev Pharmacol Toxicol. 2004;44:219-238.
32. Suchting S, Bicknell R, Eichmann A. Neuronal clues to vascular guidance. Exp Cell Res. 2006;312:668-675.
33. Vinores SA, Van Niel E, Kim HJ, et al. Simultaneous expression of keratin and glial fibrillary acidic protein by the same cells in epiretinal membranes. Invest Ophthalmol Vis Sci. 1992;33:3361-3366.
34. Machemer R, Laqua H. Pigment epithelial proliferation in retinal detachment (massive periretinal proliferation). Am J Ophthalmol. 1975;80:1-23.
35. Anderson DH, Stern WH, Fisher SK, et al. The onset of pigment epithelial proliferation after retinal detachment. Invest Ophthal-mol Vis Sci. 1981;21:10-16.
36. Wiedemann P, Weller M. The pathophysiology of proliferative vitreoretinopathy. Acta Ophthalmol. 1988;189:7-15.
37. Grierson I, Hiscott P, Sheridan C, et al. The pigment epithelium: friend and foe of the retina. Proc R Microscopical Soc. 1997;32: 161-170.
38. Lee P, Wang CC, Adamis AP. Ocular neovascularization: an epide-miologic review. Surv Ophthalmol. 1998;43:245-269.
39. Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 2001;15:188-200.
40. Sheldon H, Andre M, Legg JA, et al. Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other action nucleation-promoting factors. FASEB J. 2009;23:513-522.
41. Kaur S, Samant GV, Pramanik K, et al. Silencing of directional migration in roundabout4 knockdown endothelial cells. BMC Cell Biol. 2008;9:61.
42. Jerdan JA, Pepose JS, Michels RG, et al. Proliferative vitreoretinopa-thy membranes: an immunohistochemical study. Ophthalmology. 1989;96:801-810.
43. Araiz JJ, Refojo MF, Arroyo MH, et al. Antiproliferative effect of retinoic acid in intravitreous silicone oil in an animal model of proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 1993; 34:522-530.
44. Planck SR, Andresevic J, Chen JC, et al. Expression of growth factor mRNA in rabbit PVR model systems. Curr Eye Res. 1992; 11:1031-1039.
45. Agrawal RN, He S, Spee C, et al. In vivo models of proliferative vitreoretinopathy. Nat Protoc. 2007;2:67-77.
46. Yang CM, Olsen KR, Hernandez E, et al. Measurement of cellular proliferation within the vitreous during experimental proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol. 1992;230: 66-71.
47. Hui YN, Sorgente N, Ryan SJ. Posterior vitreous separation and retinal detachment induced by macrophages. Graefes Arch Clin Exp Ophthalmol. 1987;225:279-284.