Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo

Heart Failure Reviews

Volumn 15, Issue 2, 2010, Pages 117-120

  Flamant, Frédéric ^a   Quignodon, Laure ^a  

^a UNIVERSITÉ DE LYON   (France)

Author keywords

Nuclear receptor; Thyroid hormone; Transgenic mice

Indexed keywords

CELL NUCLEUS RECEPTOR; ISOPROTEIN; LIOTHYRONINE; MUTANT PROTEIN; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR ALPHA1; THYROID HORMONE RECEPTOR BETA; UNCLASSIFIED DRUG; CRE RECOMBINASE; INTEGRASE;

CELL TYPE; DISEASE MODEL; GENE MUTATION; GENETIC CODE; GENETIC REGULATION; HETEROZYGOSITY; HYPOTHYROIDISM; IN VIVO STUDY; NONHUMAN; PROTEIN EXPRESSION; SHORT SURVEY; TRANSGENIC MOUSE; ANIMAL; ANIMAL MODEL; GENETIC RECOMBINATION; GENETICS; METABOLISM; MOUSE; MUTATION; REVIEW;

ANIMALS; INTEGRASES; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MUTATION; RECOMBINATION, GENETIC; THYROID HORMONE RECEPTORS ALPHA; THYROID HORMONE RECEPTORS BETA; TRIIODOTHYRONINE;

EID: 77953264308     PISSN: 13824147     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10741-008-9121-y     Document Type: Short Survey

References (33)

1. Yen PM (2001) Physiological and molecular basis of thyroid hormone action. Physiol Rev 81:1097-1142
2. Flamant F, Baxter JD, Forrest D et al (2006) International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors. Pharmacol Rev 58:705-711. doi:10.1124/pr.58.4.3
3. Perissi V, Rosenfeld MG (2005) Controlling nuclear receptors: the circular logic of cofactor cycles. Nat Rev Mol Cell Biol 6:542-554. doi:10.1038/nrm1680
4. Forrest D, Vennstrom B (2000) Functions of thyroid hormone receptors in mice. Thyroid 10:41-52
5. Flamant F, Gauthier K, Samarut J (2007) Thyroid hormones signaling is getting more complex: STORMs are coming. Mol Endocrinol 21:321-333. doi:10.1210/me.2006-0035
6. Flamant F, Samarut J (2003) Thyroid hormone receptors: lessons from knockout and knock-in mutant mice. Trends Endocrinol Metab 14:85-90. doi:10.1016/S1043-2760(02)00043-7
7. Quignodon L, Vincent S, Winter H et al (2007) A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism. Mol Endocrinol 21:2350-2360. doi:10.1210/me.2007-0176
8. Tinnikov A, Nordstrom K, Thoren P et al (2002) Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1. EMBO J 21:5079-5087. doi:10.1093/emboj/cdf523
9. Kaneshige M, Suzuki H, Kaneshige K et al (2001) A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice. Proc Natl Acad Sci USA 98:15095-15100. doi:10.1073/pnas.261565798
10. Liu YY, Heymann RS, Moatamed F et al (2006) A mutant thyroid hormone receptor alpha antagonizes PPAR{alpha}-signaling in vivo and impairs fatty acid oxidation. Endocrinology 148:1206-1217
11. Mansouri A, Chowdhury K, Gruss P (1998) Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet 19:87-90. doi:10.1038/ng0598-87
12. Morte B, Manzano J, Scanlan T et al (2002) Deletion of the thyroid hormone receptor alpha 1 prevents the structural alterations of the cerebellum induced by hypothyroidism. Proc Natl Acad Sci USA 99:3985-3989. doi:10.1073/pnas.062413299
13. Gothe S, Wang Z, Ng L et al (1999) Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation. Genes Dev 13:1329-1341. doi:10.1101/gad.13. 10.1329
14. Gauthier K, Plateroti M, Harvey CB et al (2001) Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus. Mol Cell Biol 21:4748-4760. doi: 10.1128/MCB.21.14.4748-4760.2001
15. Gullberg H, Rudling M, Forrest D et al (2000) Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alpha-hydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterol. Mol Endocrinol 14:1739-1749. doi:10.1210/me.14.11.1739
16. Forrest D, Erway LC, Ng L et al (1996) Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet 13:354-357. doi:10.1038/ng0796-354
17. Ng L, Hurley JB, Dierks B et al (2001) A thyroid hormone receptor that is required for the development of green cone photoreceptors. Nat Genet 27:94-98
18. Forrest D, Hanebuth E, Smeyne RJ et al (1996) Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function. The EMBO Journal 15:3006-3015
19. Flores-Morales A, Gullberg H, Fernandez L et al (2002) Patterns of Liver Gene Expression Governed by TRbeta. Mol Endocrinol 16:1257-1268. doi:10.1210/me.16.6.1257
20. Yen PM, Feng X, Flamant F et al (2003) Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. EMBO Rep 4:581-587. doi:10.1038/sj.embor.embor862
21. Hashimoto K, Curty FH, Borges PP et al (2001) An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci USA 98:3998-4003. doi:10.1073/pnas.051454698
22. Kaneshige M, Kaneshige K, Zhu X et al (2000) Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone. Proc Natl Acad Sci USA 97:13209-13214
23. Winter H, Braig C, Zimmermann U et al (2006) Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells. J Cell Sci 119:2975-2984. doi:10.1242/jcs.03013
24. Samarut J (1996) Control of the differentiation commitment by nuclear hormone receptors in chicken erythrocytic progenitor cells. Curr Top Microbiol Immunol 212:163-173
25. Durand B, Raff M(2000)Acell-intrinsic timer that operates during oligodendrocyte development. BioEssays 22:64-71. doi:10.1002/ (SICI)1521-1878(200001)22:1<64::AID-BIES11>3.0.CO;2-Q
26. Trentin AG, Gomes FC, Lima FR et al (1998) Thyroid hormone acting on astrocytes in culture. In Vitro Cell Dev Biol Anim 34:280-282. doi:10.1007/s11626-998-0003-3
27. Quignodon L, Grijota-Martinez C, Compe E et al (2007) A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum. J Mol Endocrinol 39:17-28. doi:10.1677/JME-06-0054
28. Harvey CB, O'Shea PJ, Scott AJ et al (2002) Molecular mechanisms of thyroid hormone effects on bone growth and function. Mol Genet Metab 75:17-30. doi:10.1006/mgme.2001.3268
29. Thompson CC (1996) Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog. J Neurosci 16:7832-7840
30. Stevens DA, Harvey CB, Scott AJ et al (2003) Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol Endocrinol 12:12
31. Koibuchi N, Chin WW (2000) Thyroid hormone action and brain development. Trends Endocrinol Metab 11:123-128. doi: 10.1016/S1043-2760(00)00238-1
32. Garcia-Otin AL, Guillou F (2006) Mammalian genome targeting using site-specific recombinases. Front Biosci 11:1108-1136. doi: 10.2741/1867
33. Fossat N, Chatelain G, Brun G et al (2006) Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockout. EMBO Reports 7:824-830