Neurotoxic, myotoxic and cytolytic activities of the new basic PLA 2 isoforms BmjeTX-I and BmjeTX-II isolated from the Bothrops marajoensis (marajó lancehead) snake venom

Protein Journal

Volumn 29, Issue 2, 2010, Pages 103-113

  Ponce Soto, L A ^a   Martins De souza, D ^a,b   Marangoni, S ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Bothrops marajoensis; C2C12; Cytotoxitic; Isoforms; Myotoxin; Neurotoxin; Phospholipase a2; Snake venom

Indexed keywords

ACETYLCHOLINE; BMJETX I; BMJETX II; PHOSPHOLIPASE A2; PHOSPHOLIPID; SNAKE VENOM; UNCLASSIFIED DRUG; INTERLEUKIN 6; ISOENZYME; SECRETORY PHOSPHOLIPASE A2;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL PERMEABILITY; BOTHROPS MARAJOENSIS; CHICK; CONTROLLED STUDY; CYTOTOXICITY; EX VIVO STUDY; ION EXCHANGE CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; MYOBLAST; MYOTUBE; NEUROMUSCULAR TRANSMISSION; NEUROTOXICITY; NONHUMAN; PAW EDEMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRESYNAPTIC POTENTIAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SNAKE; TOXIN ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICALLY INDUCED DISORDER; CHICKEN; DRUG EFFECT; EDEMA; ELECTROSPRAY MASS SPECTROMETRY; ENZYMOLOGY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PHYSIOLOGY; SKELETAL MUSCLE;

BOTHROPS; BOTHROPS MARAJOENSIS; MURINAE; MUS;

AMINO ACID SEQUENCE; ANIMALS; BOTHROPS; CELL LINE; CHICKENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; CROTALID VENOMS; EDEMA; HUMANS; INTERLEUKIN-6; ISOENZYMES; MALE; MICE; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; PHOSPHOLIPASES A2, SECRETORY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77953250412     PISSN: 15723887     EISSN: 18758355     Source Type: Journal    
DOI: 10.1007/s10930-010-9229-5     Document Type: Article

References (49)

1. Avila-Aguero ML, Parýs MM, Hu S, Peterson PK, Gutiérrez JM, Lomonte B, Faingezicht I (2001) Systemic cytokine response in children bitten by snakes in Costa Rica. Ped Emerg Care 17:425-429
2. Barraviera B, Lomonte B, Tarkowski A, Hanson LA, Meira DA (1995) Acute-phase reactions, including cytokines, in patients bitten by Bothrops and Crotalus snakes in Brazil. Toxicon 33:283
3. Bon C, Changeux JP, Jeng TW, Fraenkel-Conrat H (1979) Postsynaptic effects of crotoxin and of its isolated subunits. Eur J Biochem 99(3):471-481
4. Brusés JL, Capaso J, Katz E, Pilar G (1993) Specific in vitro biological activity of snake venom myotoxins. J Neurochem 60(3):1030-1042
5. 2 BmTX-I isolated from Bothrops moojeni snake venom. Toxicon 51(8):1509-1519
6. 2 isolated from the venom of the snake Bothrops asper (terciopelo). Toxicon 36:1861-1869
7. 2. J Mol Evol 57:546-554
8. 2. Thromb Haemost 45:82-85 (Pubitemid 11155236)
9. 2: role of negatively charged phospholipids as potential membrane binding sites. Arch Biochem Biophys 391(1):56-64
10. 2 myotoxins lyse cell cultures by two distinct mechanisms. Toxicon 36:1549-1555
11. 2 isoen-zyme isolated from Lachesis muta snake venom. Biochem Pharmacol 63:1589-1597
12. Goldsby RA, Kindt TJ, Osborne BA (2000) Kuby immunology. W. H. Freeman, New York
13. 2 homologue. Toxicon 51(1):80-92
14. 2: insights into the mechanisms of local and systemic myotoxicity. Toxicon 42:915-931 Review
15. Gutiérrez JM, Rojas G, Lomonte B, Gené JA, Cerdas L (1986) Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom. Comp Biochem Physiol 85:171-175
16. 2 myotoxins from Bothrops snake venoms. Toxicon 33:1405-1424
17. 2 receptor. Arch Biochem Biophys 372:215-223
18. 2. Toxicon 34:1149-1155
19. 2 isoforms from Bothrops jararacussu snake venom. Biochimie 85(10):983-991
20. 2 enzymes: structure, function and mechanism. Wiley, Chichester, pp 1-511
21. 2 enzymes. Toxicon 42:827-840
22. 2 and beta-neurotoxicity. Biochimie 82(9-10):807-814
23. 2. Biochemistry 33:13938-13945
24. 2 ammodytoxin and crotoxin bind to distinct high-affinity protein acceptors in Torpedo marmorata electric organ. Biochemistry 36:2779-2787
25. Krizaj I, Rowan EG, Gubensek F (1995) Ammodytoxin A acceptor in bovine brain synaptic membranes. Toxicon 33:437-449
26. Kudo I, Murakami M (2002) Phospholipase A2 enzymes. Pros-taglandins Other Lipid Mediat 68-69:3-58
27. Lambeau G, Barhanin J, Schweitz H, Qar J, Lazdunski M (1989) Identification and properties of very high affinity brain membrane-binding sites for a neurotoxic phospholipase from the tai-pan venom. J Biol Chem 264(19):11503-11510
28. 2. Trends Pharmacol Sci 20:162-170
29. 2 homologues: dissociation between enzymatic and biological activities. Eur J Pharmacol 343:257-263
30. 2 purified from porcine pancreas and snake venoms. Toxicon 31(8):949-956
31. 2 of Bothrops asper snake venom. Toxicon 32(11):1359-1369
32. 2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro. Toxicon 37:145-158
33. Lomonte B, Tarkowski A, Hanson LA (1993) Host response to Bothrops asper snake venom. Analysis of edema formation, inflammatory cells, and cytokine release in a mouse model. Inflammation 17:93-105
34. Mebs D, Ownby CL (1990) Myotoxic components of snake venoms: their biochemical and biological activities. Pharmacol Ther 48:223-236
35. Moura-da-Silva AM, Desmond H, Laing G, Theakston RDG (1991) Isolation and comparison of myotoxins isolated from venoms of different species of Bothrops snakes. Toxicon 29:713-723
36. Ponce-Soto LA, Bonfim VL, Rodrigues-Simioni L, Novello JC, Marangoni S (2006) Determination of primary structure of two isoforms 6-1 and 6-2 PLA2 D49 from Bothrops jararacussu snake venom and neurotoxic characterization using in vitro neuromus-cular preparation. Protein J 25:147-155
37. 2 homologue isolated from the venom of the snake Bothrops alternatus. Bio-chim Biophys Acta 1770:585-593
38. 2 from Crotalus durissus collilineatus venom. J Protein Chem 21:131-136
39. 2. Toxicon 50(7):871-892
40. Randazzo-Moura P, Ponce-Soto LA, Rodrigues-Simioni L, Ma-rangoni S (2008) Structural characterization and neuromuscular activity of a new Lys49 phospholipase A2 homologous (Bp-12) isolated from Bothrops pauloensis snake venom. Protein J. doi: 10.1007/s10930-008-9144-1
41. 2 from Bothrops pauloensis snake venom. Toxicon 50(1):153-165
42. Rouault M, Bollinger JG, Lazdunski M, Gelb MH, Lambeau G (2003) Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. Biochemistry 42:11494-11503
43. 2 genes and their expressions in Thai Russell's viper venom glands. Toxicon 52:395-399
44. Schagger HA, Von Jagow G (1987) Comassie blue-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for direct visualization of polypeptides during electrophoresis. Anal Bio-chem 166:368-379
45. 2 and anticoagulant activities and high myotoxic activity. J Protein Chem 18:371-378
46. 2 and their receptors and binding proteins. Biochim Biophys Acta 1488:59-70
47. 2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid. Toxicon 25(5):501-515
48. 2 from the venom of Deinagkistrodon acutus. Toxicon 34:1191-1196
49. 2 isolated from Bothrops asper snake venom: role of catalytic activity. Toxicon 45:335-346