The structure activity relationship of saikosaponins and glycyrrhizin derivatives for Na+, K+-ATPase inhibiting action

Yaoxue Xuebao

Volumn 31, Issue 7, 1996, Pages 496-501

  Zhou, Q L ^c   Zhang, Z Q ^a   Nagasawa, T ^b   Hiai, S ^b  

^a Acad Tranditional Chinese Med M   (China)

^b UNIVERSITY OF TOYAMA   (Japan)

^c JILIN UNIVERSITY   (China)

Author keywords

Glycyrrhizin; K+ ATPase; Na+; Non competitive inhibition; Saikosaponin

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); DRUG DERIVATIVE; GLYCYRRHIZIC ACID; OLEANOLIC ACID; SAIKOSAPONIN; SAPOGENIN; SAPONIN;

ARTICLE; CELL FREE SYSTEM; CHEMISTRY; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION;

CELL-FREE SYSTEM; GLYCYRRHIZIC ACID; HUMANS; NA(+)-K(+)-EXCHANGING ATPASE; OLEANOLIC ACID; SAPOGENINS; SAPONINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030309258     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Nakao M, Nakao T, Tatibana M et al. Effect of inosine and adenine on adenosine triphosphate regeneration and shape transformation in long-stored erythrocytes. Biochim Biophys Acta, 1959,32:564
2. Nakao M, Nakao T, Yamazoe S et al. Adenosine triphosphate and shape of erythrocytes. J Biochem, 1961,49:487
3. Abe H, Sakaguchi M, Anno M et al. Erythrocyte membrane stabilization by plant saponins and sapogenins. Arch Pharmacol, 1981,316:262
4. Abe H, Odashima S, Arichi S. Effects of saikosaponins on biological membranes. II. Change in electronspin resonance spectra from spin-labelled erythrocyte and erythrocyte ghost membranes. Planta Med, 1978,34:287
5. Abe H, Konishi H, Komiya H et al. Effects of saikosaponins on biological membranes III. Ultrastructural studies on effects of saikosaponins on the cell surface. Planta Med, 1981,42: 356