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Volumn 33, Issue SUPPL. 5, 2010, Pages 2-11

Current developments and perspectives in targeted therapies;Aktuelle Entwicklungen und Perspektiven zielgerichteter Therapien

Author keywords

ALK fusion gene; EGFR mutation; EGFR tyrosine kinase inhibitors; IGFR inhibitors; Maintenance therapy; Non Small Cell Lung Cancer; Tumour vascular disrupting agents; VEGFR tyrosine kinase inhibitors

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; VASCULAR TARGETING AGENT; VASCULOTROPIN INHIBITOR; ANAPLASTIC LYMPHOMA KINASE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; GENETIC MARKER; NEW DRUG; ONCOPROTEIN; PROTEIN TYROSINE KINASE; SOMATOMEDIN RECEPTOR; VASCULOTROPIN RECEPTOR;

EID: 77953242701     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000313971     Document Type: Review
Times cited : (2)

References (41)
  • 1
    • 0036499649 scopus 로고    scopus 로고
    • Phase III trial comparing a defined duration of therapy versus continuous therapy followed by second-line therapy in advancedstage IIIB/IV non-small-cell lung cancer
    • Socinski MA, et al.: Phase III trial comparing a defined duration of therapy versus continuous therapy followed by second-line therapy in advancedstage IIIB/IV non-small-cell lung cancer. J Clin Oncol 2002;20:1335-1343.
    • (2002) J Clin Oncol , vol.20 , pp. 1335-1343
    • Socinski, M.A.1
  • 2
    • 77953273065 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00976456.
  • 3
    • 59149092945 scopus 로고    scopus 로고
    • Phase III study of immediate compared with delayed docetaxel after front-line therapy with gemcitabine plus carboplatin in advanced non-small-cell lung cancer
    • Fidias PM, et al.: Phase III study of immediate compared with delayed docetaxel after front-line therapy with gemcitabine plus carboplatin in advanced non-small-cell lung cancer. J Clin Oncol 2009;27:591-598.
    • (2009) J Clin Oncol , vol.27 , pp. 591-598
    • Fidias, P.M.1
  • 4
    • 70350225538 scopus 로고    scopus 로고
    • Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomised, double-blind, phase 3 study
    • Ciuleanu T, et al.: Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study. Lancet 2009; 374:1432-1440.
    • (2009) Lancet , vol.374 , pp. 1432-1440
    • Ciuleanu, T.1
  • 5
    • 70349475409 scopus 로고    scopus 로고
    • SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with firstline platin-based chemotherapy in patients with advanced NSCLC
    • abstr 8001
    • Cappuzzo F, et al.: SATURN: a double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with firstline platin-based chemotherapy in patients with advanced NSCLC. J Clin Oncol 2009;27(suppl 15): abstr 8001.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15
    • Cappuzzo, F.1
  • 6
    • 77953270673 scopus 로고    scopus 로고
    • Roche Pharma, data on file
    • Roche Pharma, data on file.
  • 8
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, et al.: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009; 361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1
  • 9
    • 76149100579 scopus 로고    scopus 로고
    • A phase II trial of erlotinib monotherapy in pretreated patients with advanced nonsmall cell lung cancer who do not possess active EGFR mutations: Okayama Lung Cancer Study Group trial 0705
    • Yoshioka H, et al.: A phase II trial of erlotinib monotherapy in pretreated patients with advanced nonsmall cell lung cancer who do not possess active EGFR mutations: Okayama Lung Cancer Study Group trial 0705. J Thorac Oncol 2010;5:99-104.
    • (2010) J Thorac Oncol , vol.5 , pp. 99-104
    • Yoshioka, H.1
  • 11
    • 51549116988 scopus 로고    scopus 로고
    • A phase II multicenter trial comparing two schedules of lapatinib (LAP) as first or second line monotherapy in subjects with advanced or metastatic non-small cell lung cancer (NSCLC) with either bronchioloalveolar carcinoma (BAC) or no smoking history
    • abstr 7611
    • Smylie M, et al.: A phase II multicenter trial comparing two schedules of lapatinib (LAP) as first or second line monotherapy in subjects with advanced or metastatic non-small cell lung cancer (NSCLC) with either bronchioloalveolar carcinoma (BAC) or no smoking history. J Clin Oncol 2007;25(suppl 18):abstr 7611.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 18
    • Smylie, M.1
  • 12
    • 56349121456 scopus 로고    scopus 로고
    • Activity and tolerance of XL647 in NSCLC patients with acquired resistance to EGFR-TKIs: Preliminary results of a phase II trial
    • abstr 8028
    • Miller VA, et al.: Activity and tolerance of XL647 in NSCLC patients with acquired resistance to EGFR-TKIs: Preliminary results of a phase II trial. J Clin Oncol 2008;26(suppl):abstr 8028.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Miller, V.A.1
  • 13
    • 71649101503 scopus 로고    scopus 로고
    • A phase II study of BIBW 2992, a novel irreversible dual EGFR and HER2 tyrosine kinase inhibitor (TKI), in patients with adenocarcinoma of the lung and activating EGFR mutations after failure of one line of chemotherapy (LUXLung 2)
    • abstr 8013
    • Shih J, et al.: A phase II study of BIBW 2992, a novel irreversible dual EGFR and HER2 tyrosine kinase inhibitor (TKI), in patients with adenocarcinoma of the lung and activating EGFR mutations after failure of one line of chemotherapy (LUXLung 2). J Clin Oncol 2009;27(suppl 15):abstr 8013.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15
    • Shih, J.1
  • 14
    • 56349167837 scopus 로고    scopus 로고
    • Preliminary activity and safety results from a phase i clinical trial of PF-00299804, an irreversible pan-HER inhibitor, in patients (pts) with NSCLC
    • abstr 8027
    • Janne PA, et al.: Preliminary activity and safety results from a phase I clinical trial of PF-00299804, an irreversible pan-HER inhibitor, in patients (pts) with NSCLC. J Clin Oncol 2008;26(suppl):abstr 8027.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Janne, P.A.1
  • 15
    • 77953259726 scopus 로고    scopus 로고
    • Molecular signature of NSCLC patients responding to anti-IGF-1R therapy
    • abstr 26
    • Gualberto A, et al.: Molecular signature of NSCLC patients responding to anti-IGF-1R therapy. Mol Markers 2008;abstr 26.
    • (2008) Mol Markers
    • Gualberto, A.1
  • 17
    • 33947495794 scopus 로고    scopus 로고
    • Insulin-like growth factor-related signalling and cancer development
    • Pollak M: Insulin-like growth factor-related signalling and cancer development. Recent Results Cancer Res 2007;174:49-53.
    • (2007) Recent Results Cancer Res , vol.174 , pp. 49-53
    • Pollak, M.1
  • 18
    • 34548018304 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 receptor in cancer: Old focus, new future
    • Hartog H, et al.: The insulin-like growth factor 1 receptor in cancer: old focus, new future. Eur J Cancer 2007;43:1895-1904.
    • (2007) Eur J Cancer , vol.43 , pp. 1895-1904
    • Hartog, H.1
  • 19
    • 46749156706 scopus 로고    scopus 로고
    • Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
    • Guix M, et al.: Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest 2008; 118:2609-2619.
    • (2008) J Clin Invest , vol.118 , pp. 2609-2619
    • Guix, M.1
  • 20
    • 66349091290 scopus 로고    scopus 로고
    • Phase II study of the anti-insulinlike growth factor type 1 receptor antibody CP-751 871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
    • Karp DD, et al.: Phase II study of the anti-insulinlike growth factor type 1 receptor antibody CP-751 871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol 2009;27:2516-2522.
    • (2009) J Clin Oncol , vol.27 , pp. 2516-2522
    • Karp, D.D.1
  • 21
    • 77953239284 scopus 로고    scopus 로고
    • www.pfizer.com, Presseinformation 29.12.2009.
    • (2009) Presseinformation , vol.29 , pp. 12
  • 22
    • 76149087441 scopus 로고    scopus 로고
    • Antiangiogenic agents and vascular disrupting agents for the treatment of lung cancer
    • Clément-Duchêne C, et al.: Antiangiogenic agents and vascular disrupting agents for the treatment of lung cancer. J Thorac Oncol 2010;5:129-139.
    • (2010) J Thorac Oncol , vol.5 , pp. 129-139
    • Clément-Duchêne, C.1
  • 23
    • 57449103348 scopus 로고    scopus 로고
    • Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage MJ, et al.: Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Br J Cancer 2008;99:2006-2012.
    • (2008) Br J Cancer , vol.99 , pp. 2006-2012
    • McKeage, M.J.1
  • 24
    • 67449123059 scopus 로고    scopus 로고
    • Phase II study of ASA404 (vadimezan 56-dimethylxanthenone-4-acetic acid/ DMXXA) 1800 mg/m2 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage MJ, et al.: Phase II study of ASA404 (vadimezan, 5,6-dimethylxanthenone-4-acetic acid/ DMXXA) 1800 mg/m2 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Lung Cancer 2009;65: 192-197.
    • (2009) Lung Cancer , vol.65 , pp. 192-197
    • McKeage, M.J.1
  • 25
    • 70450216884 scopus 로고    scopus 로고
    • Comparison of safety and efficacy between squamous and non-squamous nonsmall cell lung cancer (NSCLC) patients in phase II studies of DMXAA (ASA404)
    • abstr 8072
    • McKeage MJ, et al.: Comparison of safety and efficacy between squamous and non-squamous nonsmall cell lung cancer (NSCLC) patients in phase II studies of DMXAA (ASA404). J Clin Oncol 2008; 26(suppl):abstr 8072.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • McKeage, M.J.1
  • 26
    • 35948978403 scopus 로고    scopus 로고
    • Randomized phase II study of vandetanib alone or in combination with carboplatin and paclitaxel as first-line treatment for advanced non-small cell lung cancer (NSCLC)
    • abstr 7544
    • Heymach J, et al.: Randomized phase II study of vandetanib alone or in combination with carboplatin and paclitaxel as first-line treatment for advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007;25(suppl 18):abstr 7544.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 18
    • Heymach, J.1
  • 27
    • 70349474058 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL)
    • abstr 8010
    • De Boer R, et al.: Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL). J Clin Oncol 2009;27(suppl 15):abstr 8010.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15
    • De Boer, R.1
  • 28
    • 69349097838 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZODIAC)
    • abstr CRA8003
    • Herbst RS, et al.: Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZODIAC). J Clin Oncol 2009;27(suppl 18): abstr CRA8003.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 18
    • Herbst, R.S.1
  • 29
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST)
    • abstr 8009
    • Natale RB, et al.: Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST). J Clin Oncol 2009;27(suppl 15):abstr 8009.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15
    • Natale, R.B.1
  • 30
    • 45849149177 scopus 로고    scopus 로고
    • Phase III trial comparing carboplatin and paclitaxel with or without sorafenib in chemonaive patients with stage IIIB (with effusion) or IV non-small cell lung cancer Geneva
    • Scagliotti G, et al.: Phase III trial comparing carboplatin and paclitaxel with or without sorafenib in chemonaive patients with stage IIIB (with effusion) or IV non-small cell lung cancer. Geneva, 1st IASLC-ESMO European Lung Cancer Conference, 2008:48.
    • (2008) 1st IASLC-ESMO European Lung Cancer Conference , vol.48
    • Scagliotti, G.1
  • 31
    • 39149120621 scopus 로고    scopus 로고
    • Multicenter, phase II trial of sunitinib in previously treated, advanced non-smallcell lung cancer
    • Socinski MA, et al.: Multicenter, phase II trial of sunitinib in previously treated, advanced non-smallcell lung cancer. J Clin Oncol 2008;26:650-656.
    • (2008) J Clin Oncol , vol.26 , pp. 650-656
    • Socinski, M.A.1
  • 32
    • 36749052079 scopus 로고    scopus 로고
    • Efficacy and safety of continuous daily sunitinib dosing in previously treated advanced non-small cell lung cancer (NSCLC): Results from a phase II study
    • abstr 7542
    • Brahmer JR, et al.: Efficacy and safety of continuous daily sunitinib dosing in previously treated advanced non-small cell lung cancer (NSCLC): results from a phase II study. J Clin Oncol 2007;25 (suppl 18):abstr 7542.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 18
    • Brahmer, J.R.1
  • 33
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F, et al.: BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008;68:4774-4782.
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1
  • 34
    • 37549024347 scopus 로고    scopus 로고
    • A double blind phase II study of BIBF 1120 in patients suffering from relapsed advanced non-small cell lung cancer (NSCLC)
    • abstr 7635
    • Von Pawel J, et al.: A double blind phase II study of BIBF 1120 in patients suffering from relapsed advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007;25(suppl 18):abstr 7635.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 18
    • Von Pawel, J.1
  • 35
    • 66149188254 scopus 로고    scopus 로고
    • Baseline vascular endothelial growth factor concentration as potential predictive marker of benefit from vandetanib in non-small cell lung cancer
    • Hanrahan EO, et al.: Baseline vascular endothelial growth factor concentration as potential predictive marker of benefit from vandetanib in non-small cell lung cancer. Clin Cancer Res 2009;15:3600-3609.
    • (2009) Clin Cancer Res , vol.15 , pp. 3600-3609
    • Hanrahan, E.O.1
  • 36
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, et al.: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1
  • 37
    • 33746133158 scopus 로고    scopus 로고
    • Biological and clinical implications of EGFR mutations in lung cancer
    • Mitsudomi T, et al.: Biological and clinical implications of EGFR mutations in lung cancer. Int J Clin Oncol 2006;11:190-198.
    • (2006) Int J Clin Oncol , vol.11 , pp. 190-198
    • Mitsudomi, T.1
  • 38
    • 70349720358 scopus 로고    scopus 로고
    • Biomarker analyses from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small cell lung cancer (NSCLC) in Asia (IPASS)
    • abstr 8006
    • Fukuoka M, et al.: Biomarker analyses from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small cell lung cancer (NSCLC) in Asia (IPASS). J Clin Oncol 2009;27(suppl 15):abstr 8006.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15
    • Fukuoka, M.1
  • 39
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, et al.: Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009;361:958-967.
    • (2009) N Engl J Med , vol.361 , pp. 958-967
    • Rosell, R.1
  • 40
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, et al.: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448:561-566.
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1
  • 41
    • 70350140489 scopus 로고    scopus 로고
    • Clinical activity observed in a phase i dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066
    • abstr 3509
    • Kwak EL, et al.: Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066. J Clin Oncol 2009;27 (suppl 15):abstr 3509.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15
    • Kwak, E.L.1


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