Polymerase chain reaction (PCR) detection of B cell clonality in Sjögren's syndrome patients: A diagnostic tool of clonal expansion

Clinical and Experimental Immunology

Volumn 161, Issue 1, 2010, Pages 57-64

  Guzman L M ^a   Castillo, D ^b   Aguilera, S O ^c  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

^b INSTITUTO DE SALUD PÚBLICA DE CHILE   (Chile)

^c UNIVERSIDAD ANDRÉS BELLO   (Chile)

Author keywords

B cell clonality; Chronic sialadenitis; Immunoglobulin heavy chain gene; PCR

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN BCL 2;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CLONAL VARIATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE REARRANGEMENT; GENE SEQUENCE; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROENVIRONMENT; NONHODGKIN LYMPHOMA; ONCOGENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SALIVARY GLAND; SIALOADENITIS; SJOEGREN SYNDROME;

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; B-LYMPHOCYTE SUBSETS; CELL LINEAGE; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; CLONE CELLS; DISEASE PROGRESSION; DISEASE SUSCEPTIBILITY; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, BCL-2; HUMANS; LYMPHOMA, B-CELL; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; SALIVARY GLANDS, MINOR; SENSITIVITY AND SPECIFICITY; SIALADENITIS; SJOGREN'S SYNDROME; TRANSLOCATION, GENETIC; YOUNG ADULT;

EID: 77953241244     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04144.x     Document Type: Article

References (40)

1. Fox RI, Howell FV, Bone RC, Michelson P. Primary Sjögren syndrome: clinical and immunopathologic features. Semin Arthritis Rheum 1984 14 : 77 105.
2. Anaya J-M, Vega P, Correa PA et al. Síndrome de Sjögren. In : Anaya JM, Shoenfeld Y, Correa PA, García-Carrasco M, Cervera R, eds. Autoinmunidad y Enfermedad Autoinmune [Autoimmunity and Autoimmune Disease].
3. Martin T, Weber JC, Levallois H et al. Salivary gland lymphomas in patients with Sjögren's syndrome may frequently develop from rheumatoid factor B cells. Arthritis Rheum 2000 43 : 908 916.
4. Szodoray P, Jonsson R. The BAFF/APRIL system in systemic autoimmune diseases with a special emphasis on Sjögren's syndrome. Scand J Immunol 2005 62 : 421 428.
5. Dong L, Masaki Y, Takegami T et al. Clonality analysis of lymphoproliferative disorders in patients with Sjögren's syndrome. Clin Exp Immunol 2007 150 : 279 284.
6. Kassan SS, Thomas TL, Moutsopoulos HM et al. Increased risk of lymphoma in sicca syndrome. Ann Intern Med 1978 89 : 888 892.
7. Tonami H, Matoba M, Yokota H, Higashi K, Yamamoto I, Sugai S. Mucosa-associated lymphoid tissue lymphoma in Sjögren's syndrome: initial and follow-up imaging features. Am J Roentgenol 2002 179 : 485 489.
8. Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue: A distinctive type of B-cell lymphoma. Cancer 1983 52 : 1410 1416.
9. Briones J, Timmerman JM, Hilbert DM, Levy R. BLyS and BLyS receptor expression in non-Hodgkin's lymphoma. Exp Hematol 2002 30 : 135 141.
10. Küppers R, Klein U, Hansmann ML, Rajewsky K. Cellular origin of human B-cell lymphomas. N Engl J Med 1999 341 : 1520 1529.
11. Thériault C, Galoin S, Valmary S et al. PCR analysis of immunoglobulin heavy chain (IgH) and TCR-g chain gene rearrangements in the diagnosis of lymphoproliferative disorders: results of a study of 525 cases. Mod Pathol 2000 13 : 1269 1279.
12. Fais F, Ghiotto F, Hashimoto S et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998 102 : 1515 1525.
13. Itoh K, Patki V, Furie RA et al. Clonal expression is a characteristic feature of the B-cell repertoire of patients with rheumatoid arthritis. Arthritis Res 2000 2 : 50 8.
14. Retamales E, Rodriguez L, Guzmán L et al. Analytical detection of immunoglobulin heavy chain gene rearrangements in gastric lymphoid infiltrates by peak area analysis of the melting curve in the LightCycler System. J Mol Diagn 2007 9 : 351 357.
15. Arnold A, Cossman J, Bakhshi A, Jaffe ES, Waldmann TA, Korsmeyer SJ. Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med 1983 309 : 1593 1599.
16. Segal GH, Jorgensen T, Masih AS, Braylan RC. Optimal primer selection for clonality assessment by polymerase chain reaction analysis: I. Low grade B-cell lymphoproliferative disorders of nonfollicular center cell type. Hum Pathol 1994 25 : 1269 1275.
17. Aubin J, Davi F, Nguyen-Salomon F et al. Description of a novel FR1 IgH PCR strategy and its comparison with three other strategies for the detection of clonality in B cell malignancies. Leukemia 1995 9 : 471 479.
18. Uchiyama M, Maesawa C, Yashima A et al. Development of consensus fluorogenically labeled probes of the immunoglobulin heavy-chain gene for detecting minimal residual disease in B-cell non-Hodgkin lymphomas. Cancer Sci 2003 94 : 877 885.
19. Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol 1968 21 : 656 660.
20. Daniels TE, Whitcher JP. Association of patterns of labial salivary gland inflammation with keratoconjunctivitis sicca. Analysis of 618 patients with suspected Sjögren's syndrome. Arthritis Rheum 1994 37 : 869 877.
21. Crescenzi M, Seto M, Herzig GP, Weiss PD, Griffith RC, Korsmeyer SJ. Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease. Proc Natl Acad Sci USA 1988 85 : 4869 4873.
22. Ngan BY, Nourse J, Cleary ML. Detection of chromosomal translocation t(14;18) within the minor cluster region of bcl-2 by polymerase chain reaction and direct genomic sequencing of the enzymatically amplified DNA in follicular lymphomas. Blood 1989 73 : 1759 1762.
23. Vitali C, Bombardieri S, Jonsson R et al. Classification criteria for Sjögren's syndrome: A revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002 61 : 554 558.
24. Daniel TE. Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases. Arthritis Rheum 1984 27 : 147 156.
25. Diss TC, Pan L, Wotherspoon AC, Isaacson PG. Sources of DNA for detecting B cell monoclonality using PCR. J Clin Pathol 1994 47 : 493 496.
26. De Vita S, Ferraccioli G, De Re V et al. The polymerase chain reaction detects B cell clonalities in patients with Sjögren's syndrome and suspected malignant lymphoma. J Rheumatol 1994 21 : 1497 1501.
27. 2 from contingency tables, and the calculation of P. J R Stat Soc 1922 85 : 87 94.
28. Bahler DW, Miklos JA, Swerdlow SH. Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas. Blood 1997 89 : 3335 3344.
29. Kato K, Ohshima K, Shiokawa S, Shibata T, Suzumiya J, Kikuchi M. Rearrangement of immunoglobulin heavy and light chains and VH family in thyroid and salivary gland lymphomas. Pathol Int 2002 52 : 747 754.
30. Theander E, Henriksson G, Ljungberg O, Mandl T, Manthorpe R, Jacobsson LT. Lymphoma and other malignancies in primary Sjögren's syndrome: A cohort study on cancer incidence and lymphoma predictors. Ann Rheum Dis 2006 65 : 796 803.
31. Trainor KJ, Brisco MJ, Story CJ, Morley AA. Monoclonality in B-lymphoproliferative disorders detected at the DNA level. Blood 1990 75 : 2220 2222.
32. Pablos JL, Carreira PE, Morillas L, Montalvo G, Ballestin C, Gómez-Reino JJ. Clonally expanded lymphocytes in the minor salivary glands of Sjögren's syndrome patients without lymphoproliferative disease. Arthritis Rheum 1994 37 : 1441 1444.
33. Jordan RC, Odell EW, Speight PM. B-cell monoclonality in salivary lymphoepithelial lesions. Eur J Cancer B Oral Oncol 1996 32B : 38 44.
34. Mariette X. Lymphomas complicating Sjögren's syndrome and hepatitis C virus infection may share a common pathogenesis: chronic stimulation of rheumatoid factor B cells. Ann Rheum Dis 2001 60 : 1007 1010.
35. Fishleder A, Tubbs R, Hesse B, Levine H. Uniform detection of immunoglobulin-gene rearrangement in benign lymphoepithelial lesions. N Engl J Med 1987 316 : 1118 1121.
36. Knowles DM, Athan E, Ubriaco A et al. Extranodal noncutaneous lymphoid hyperplasias represent a continuous spectrum of B-cell neoplasia: demonstration by molecular genetic analysis. Blood 1989 73 : 1635 1645.
37. Ihrler S, Baretton GB, Menauer F, Blasenbreu-Vogt S, Löhrs U. Sjögren's syndrome and MALT lymphomas of salivary glands: A DNA-cytometric and interphase-cytogenetic study. Mod Pathol 2000 13 : 4 12.
38. Schüler F, Hirt C, Dölken G. Chromosomal translocation t(14;18) in healthy individuals. Semin Cancer Biol 2003 13 : 203 209.
39. Jonsson MV, Szodoray P, Jellestad S et al. Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjögren's syndrome. J Clin Immunol 2005 25 : 189 201.
40. Tapinos NI, Polihronis M, Moutsopoulos HM. Lymphoma development in Sjögren's syndrome. Novel p53 mutations. Arthritis Rheum 1999 42 : 1466 1472.