PCR analysis of immunoglobulin heavy chain (IgH) and TcR-γ chain gene rearrangements in the diagnosis of lymphoproliferative disorders: Results of a study of 525 cases

Modern Pathology

Volumn 13, Issue 12, 2000, Pages 1269-1279

  Thériault, Catherine ^a   Galoin, Sandrine ^a   Valmary, Severine ^a   Selves, Janick ^a   Lamant, Laurence ^a   Roda, Daniel ^a   Rigal Huguet, Françoise ^a   Brousset, Pierre ^a   Delsol, Georges ^a   Al Saati, Talal ^a  

^a CHU PURPAN   (France)

Author keywords

bcl 2 JH; Clonality; IgH; Lymphoid proliferations; Multiple PCR run approach; PCR; TcR

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ADOLESCENT; ADULT; AGED; ARTICLE; B CELL LYMPHOMA; CHILD; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE COURSE; FEMALE; GASTROINTESTINAL BIOPSY; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; LYMPHOCYTE CLONE; LYMPHOCYTE SUBPOPULATION; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MALE; MORPHOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPRODUCIBILITY; SKIN BIOPSY; T CELL LYMPHOMA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; FEMALE; GENE REARRANGEMENT; GENES, BCL-2; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; INFANT; LYMPHATIC DISEASES; LYMPHOMA, B-CELL; LYMPHOMA, T-CELL; LYMPHOPROLIFERATIVE DISORDERS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA;

EID: 17744383175     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3880232     Document Type: Article

References (62)

1. Assessment of B-cell clonality by the polymerase chain reaction: A pragmatic overview
2. Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction
3. Improved PCR method for detecting monoclonal immunoglobulin heavy chain rearrangement in B cell neoplasms
4. An improved method for the detection of B-lymphoid clonality by polymerase chain reaction
5. Description of a novel FR1 IgH PCR strategy and its comparison with three other strategies of clonality in B cell malignancies
6. The use of the polymerase chain reaction in the diagnosis of B-cell lymphomas from formalin-fixed paraffin-embedded tissue
7. Detection of immunoglobulin gene rearrangement of B cell non-Hodgkin's lymphomas and leukemias in fresh, unfixed and formalin-fixed, paraffin-embedded tissue by polymerase chain reaction
8. Optimal primer selection for clonality assessment by polymerase chain reaction analysis: I. Low grade B-cell lymphoproliferative disorders of nonfollicular center cell type
9. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
10. Cellular origin of human B-cell lymphomas
11. Optimal primer selection for clonality assessment by polymerase chain reaction analysis. III: Intermedíate and high-grade B-cell neoplasms
12. Comparison of PCR with Southern hybridization for the routine detection of immunoglobulin heavy chain gene rearrangements
13. Optimal primer selection for clonality assessment by polymerase chain reaction analysis: II. Follicular lymphomas
14. New subgroups in the human T cell rearranging Vγ gene locus
15. Excision of the T cell receptor gene support a progressive rearrangement model of the α/δ locus
16. Detection of T-cell clonality in paraffin-embedded tissues
17. A simplified method of detection of clonal rearrangements of the T-cell receptor-γ chain gene
18. Evaluation of the sensitivity, specificity and reproducibility of an optimized method for detecting clonal rearrangements of immunoglobulin and T-cell receptor genes in formalin-embedded sections
19. Improved polymerase chain reaction detection of clonal T-cell lymphoid neoplasms
20. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group
21. Immunohistochemical demonstration of leucocyte differentiation antigens on paraffin sections using a modified AMeX (ModAMeX) method
22. IgH and TcR-γ gene rearrangements in Hodgkin's disease by PCR demonstrate lack of correlation between genotype, phenotype and Epstein-Barr virus status
23. Sensitive and reproducible detection of occult disease in patients with follicular lymphoma by PCR amplification of t(14;18) both pre- and post-treatment
24. Polymerase chain reaction on cerebrospinal fluid cells in the detection of leptomeningeal involvement by B-cell lymphoma and leukemia: A novel strategy and its implications
25. Structure and biological activity of human homologs of the raf/mil oncogene
26. Single-cell cDNA-PCR: Removal of contaminating genomic DNA from total RNA using immobilized DNase I
27. Avoiding false positives with PCR
28. Use of oligonucleotide probes directed against T cell antigen receptor gamma delta variable-(diversity)-joining junctional sequences as a general method for detecting minimal residual disease in acute lymphoblastic leukemias
29. Analysis of the expression of the hybrid gene bcl-2/IgH in follicular lymphomas
30. Detection of chromosomal translocation t(14;18) within the minor cluster region of bcl-2 by polymerase chain reaction and direct genomic sequencing of the enzymatically amplified DNA in follicular lymphomas
31. Oligonucleotide clonospecific probe directed against the junctional sequence of t(14;18): A new tool for the assessment of minimal residual disease in follicular lymphomas
32. Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease
33. PCR for T-cell rearrangements
34. Determination of clonality in patients who present with diagnosis dilemmas: A laboratory experience and review of the literature
35. Mycosis fungoides and Sezary syndrome
36. CD30 antigen expression in florid immunoblastic proliferations. A clinicopathologic study of 14 cases
37. Detection of residual disease in follicular lymphomas using the PCR technique: Importance of clono-specific probes
38. Geographic variance in the frequency of the t(14;18) in follicular lymphoma: An Israeli series compared to the world literature
39. Cutaneous T-cell infiltrates: Analysis of T-cell receptor γ gene rearrangement by polymerase chain reaction and denaturing gradient electrophoresis
40. Detection of clonal T-cell receptor gamma gene rearrangements with the use of the polymerase chain reaction in cutaneous lesions of mycosis fungoides and Sezary syndrome
41. Immunophenotypic and gene rearrangement analysis provide additional criteria to differentiate between cutaneous and pseudo-T-cell lymphomas
42. Pattern of T cell receptor gamma gene rearrangement and expression in B and T lymphoid malignancies
43. T cell γ gene rearrangement in hematologic neoplasms
44. Human T cell γ genes are frequently rearranged in B-lineage acute lymphoblastic leukemias but not in chronic B cell proliferations
45. Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes
46. Genotypic analysis of lymph node biopsies
47. The polymerase chain reaction in the demonstration of monoclonality in T cell lymphomas
48. Analysis of immunoglobulin, T cell receptor and bcr rearrangements in human malignant lymphoma and Hodgkin's disease
49. Genotype study of non-Hodgkin's lymphoma
50. Restricted Vβ gene usage of tumour-infiltrating T lymphocytes in primary gastric B-cell lymphoma
51. Monoclonal B cells and restricted oligoclonal T cells in T-cell-rich B-cell lymphoma
52. Amplification of TCRβ gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal
53. Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma
54. Clonal populations of CD4+ and CD8+ T cells in patients with multiple myeloma and paraproteinemia
55. Clonal populations of T cells in normal elderly humans: The T cell equivalent to "benign monoclonal gammapathy"
56. Autoimmune connective tissue disease, chronic polyarthritides and B cell expansion; risks and perspectives with immunosuppressive drugs
57. Immunosuppression, autoimmunity, and lymphoproliferative disorders
58. Analysis of T-cell receptor variability in tumor-infiltrating lymphocytes from a human regressive melanoma. Evidence for in situ T cell clonal expansion
59. T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor beta-chain CDR3 size determination: Evidence for oligoclonal expansions in tumours and inflammatory diseases
60. Frequent clonal expansion of peripheral T cells in patients with autoimmune diseases: A novel detecting system possibly applicable to laboratory examination
61. Diversity in junctional sequences associated with the common human Vγ9 and Vδ2 gene segments in normal blood and lung compared with the limited diversity in a granulomatous disease
62. Clonal expansion of lung Vδ1 + T cells in pulmonary sarcoidosis