The effects of peroral glycerol on plasma osmolarity in diabetic patients and healthy individuals

Basic and Clinical Pharmacology and Toxicology

Volumn 105, Issue 5, 2009, Pages 289-293

  Thornit, Dorte Nellemann ^a   Sander, Birgit ^a   La Cour, Morten ^a   Lund Andersen, Henrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCEROL;

ADULT; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DIZZINESS; DRUG MEGADOSE; FATIGUE; FEMALE; GLUCOSE BLOOD LEVEL; HEADACHE; HUMAN; HYPERTENSION; HYPOGLYCEMIA; LOW DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; PLASMA OSMOLARITY; PRIORITY JOURNAL; RESTLESSNESS;

ADMINISTRATION, ORAL; ADULT; AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLYCEROL; HUMANS; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION;

EID: 70350035524     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2009.00462.x     Document Type: Article

References (23)

1. Sommer S, Nau R, Wieland E, Prange HW. Pharmacokinetics of glycerol administered orally in healthy volunteers. Arzneimittelforschung 1993 43 : 744 747.
2. Odland M. Virkning PåØyets Trykk Og Det Intrakranielle Trykket Av Glycerol (Glycerin) Per Os. Tidsskr Nor Laegeforen 1966 86 : 1335 1338.
3. McCurdy DK, Schneider B, Scheie HG. Oral glycerol: the mechanism of intraocular hypotension. Am J Ophthalmol 1966 61 : 1244 1249.
4. Galin MA, Binkhorst RD, Kwitko ML. Ocular dehydration. Am J Ophthalmol 1968 66 : 233 235.
5. Mehra KS, Singh R, Char JN, Rajyashree K. Lowering of intraocular tension. Effects of isosorbide and glycerin. Arch Ophthalmol 1971 85 : 167 168.
6. el-Shewy TM, el-Sayed ME. Studies on the effect of intravenous administration of glycerol solution on the intraocular pressure. Ophthalmologica 1974 168 : 39 46.
7. Rottenberg DA, Hurwitz BJ, Posner JB. Effect of oral glycerol on intraventricular pressure in man. Neurology 1977 27 : 600 608.
8. Wald SL, McLaurin RL. Oral glycerol for the treatment of traumatic intracranial hypertension. J Neurosurg 1982 56 : 323 331.
9. Robergs RA, Griffin SE. Glycerol. Biochemistry, pharmacokinetics and clinical and practical applications. Sports Med 1998 26 : 145 167.
10. Sarda RP, Charan H, Ohri RN. Ocular tension and electrolyte changes after glycerol. A study of blood and aqueous humor in normal rabbits and those in which intraocular pressure has been raised artificially. Int Surg 1967 48 : 63 8.
11. Waterhouse JM, Coxon RV. The entry of glycerol into brain tissue. J Neurol Sci 1970 10 : 305 311.
12. Guisado R, Arieff AI, Massry SG. Effects of glycerol infusions on brain water and electrolytes. Am J Physiol 1974 227 : 865 872.
13. Tourtellotte WW, Reinglass JL, Newkirk TA. Cerebral dehydration action of glycerol. I. Historical aspects with emphasis on the toxicity and intravenous administration. Clin Pharmacol Ther 1972 13 : 159 171.
14. Frank MS, Nahata MC, Hilty MD. Glycerol: a review of its pharmacology, pharmacokinetics, adverse reactions, and clinical use. Pharmacotherapy 1981 1 : 147 160.
15. Ferber J, Rabinowitsch S. Increase in blood sugar following the ingestion of glycerol. Am J Med Sci 1929 177 : 827 832.
16. Pelkonen R, Nikkila EA, Kekki M. Metabolism of glycerol in diabetes mellitus. Diabetologia 1967 3 : 1 8.
17. Hurwitz BJ, Rottenberg DA. Letter: glycerol, cerebral oedema, and diabetes. Lancet 1975 2 : 369.
18. D'Alena P, Ferguson W. Adverse effects after glycerol orally and mannitol parenterally. Arch Ophthalmol 1966 75 : 201 203.
19. Oakley DE, Ellis PP. Glycerol and hyperosmolar nonketotic coma. Am J Ophthalmol 1976 81 : 469 472.
20. Duncan LS Jr., Ellis PP, Paterson CA. Effect of hyperosmotic agents on vitreous osmolality. Exp Eye Res 1970 10 : 129 132.
21. American Diabetes Association. Standards of medical care in diabetes-2009. Diabetes Care 2009 32 (Suppl 1 S13 61.
22. Ives HE, Warnock DG. Diuretic agents. In : Katzung BG (ed Basic and Clinical Pharmacology, 6th edn. Appleton and Lange, East Norwalk, CT, USA, 1995 230 249.
23. Lord RC. Osmosis, osmometry, and osmoregulation. Postgrad Med J 1999 75 : 67 73.