Dual influence of colloidal silica on skin deposition of vitamins C and e simultaneously incorporated in topical microemulsions

Drug Development and Industrial Pharmacy

Volumn 36, Issue 7, 2010, Pages 852-860

  Rozman, Branka ^a   Gosenca, Mirjam ^a   Gasperlin, Mirjana ^a   Padois, Karine ^b   Falson, Franciose ^b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Colloidal silica; Microemulsions; Skin delivery; Solubilization capacity; Vitamin C; Vitamin E

Indexed keywords

AEROSIL; ALPHA TOCOPHEROL; ASCORBIC ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; MICROEMULSION; NONHUMAN; PARTITION COEFFICIENT; SKIN WATER LOSS; STRATUM CORNEUM; SWINE;

ADMINISTRATION, CUTANEOUS; ANIMALS; ASCORBIC ACID; COLLOIDS; DRUG CARRIERS; EMULSIFYING AGENTS; EMULSIONS; SILICON DIOXIDE; SWINE; TECHNOLOGY, PHARMACEUTICAL; VITAMIN E; VITAMINS;

EID: 77953239598     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639040903541187     Document Type: Article

References (29)

1. Kreilgaard M. (2002). Influence of microemulsions on cutaneous drug delivery. Adv Drug Deliv Rev, 54(Suppl. 1):77-98.
2. Moulik SP, Paul BK. (1998). Structure, dynamics and transport properties of microemulsions. Adv Colloid Interface Sci, 78:99-195.
3. Pappinen S, Urtti A. (2006). Microemulsions in topical drug delivery. In: Smith E6FFV02, Maibach HI, eds. Percutaneous penetration enhancers. Ne6ffv02 York: Taylor & Francis.
4. Bonacucina G, Cespi M, Misici-Falzi M, Palmieri GF. (2008). Colloidal soft matter as drug delivery system. J Pharm Sci, 98:1-42.
5. Eccleston GM. (1994). Microemulsions. In: S6ffv02arbirck J, Boylan JC, eds. Encyclopedia of pharmaceutical technology. Ne6ffv02 York: Marcel Dekker, 411-2.
6. Libster D, Aserin A, Garti N. (2006). A novel dispersion method comprising a nucleating agent solubilized in a microemulsion, in polymeric matrix II microemulsion characterization. J Colloid Interface Sci, 302:322-9.
7. Spiclin P, Homar M, Zupancic-Valant A, Gasperlin M. (2003). Sodium ascorbyl phosphate in topical microemulsions. Int J Pharm, 256:65-73.
8. Rozman B, Gasperlin M. (2007). Stability of vitamins C and E in topical microemulsions for combined antioxidant therapy. Drug Deliv, 14:235-45.
9. AEROSIL® Fumed Silica - more than just a po6ffv02der. http// 6ffv026ffv026ffv02.aerosil.com [accessed November 20, 2008].
10. Morefield E, Seyer J. (2003). Colloidal silicon dioxide. In: Ro6ffv02e RC, Sheskey PJ, 6FFV02eller PJ, eds. Handbook of pharmaceutical excipients. London: Pharmaceutical Press, 61-164.
11. Olhero SM, Ferreira JMF. (2004). Influence of particle size on rheology and particle packing of silica-based suspensions. Po6ffv02der Technol, 139:69-75.
12. Pinnell SR. (2003). Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol, 48:1-19.
13. Burke KE. (2007). Interaction of vitamins C and E as better cosmeceuticals. Dermatol Ther, 20:314-21.
14. Farris PK. (2005). Topical vitamin C: A useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg, 31:814-7.
15. Thiele JJ, Ekanayake-Mudiyanselage S. (2007). Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Mol Aspects Med, 28:646-67.
16. Lin JY, Selim MA, Shea CR, Grichnik JM, Omar MM, Monteiro-Riviere NA, et al. (2003). UV photoprotection by combination topical antioxidants vitamin C and vitamin E. J Am Acad Dermatol, 48:866-74.
17. Niki E, Noguchi N, Tsuchihashi H, Gotoh N. (1995). Interaction among vitamin C, vitamin E, and beta-carotene. Am J Clin Nutr, 62:1322S-6S.
18. Svobodova A, 6FFV02alterova D, Vostalova J. (2006). Ultraviolet light induced alteration to the skin. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 150:25-38.
19. Heuschkel S, Goebel A, Neubert RH. (2008). Microemulsions - modern colloidal carrier for dermal and transdermal drug delivery. J Pharm Sci, 97:603-31.
20. Rozman B, Gasperlin M, Tinois-Tessoneaud E, Pirot F, Falson F. (2009). Simultaneous absorption studies of vitamins C and E from topical microemulsions using reconstructed human epidermis as human skin model. Eur J Pharm Biopharm, 72:69-75.
21. Fentem JH, Briggs D, Chesne C, Elliott GR, Harbell J6FFV02, Heylings JR, et al. (2001). A prevalidation study on in vitro tests for acute skin irritation: Results and evaluation by the Management Team. Toxicol In Vitro, 15:57-93.
22. Mosmann T. (1983). Rapid colorimetric assay for cellular gro6ffv02th and survival: Application to proliferation and cytotoxicity assays. J Immun Methods, 65:55-63.
23. Quinn PJ. (2007). Molecular associations of vitamin E. Vitam Horm, 76:67-98.
24. Dixit RP, Nagarsenker MS. (2007). Dry adsorbed emulsion of simvastatin: Optimization and in vivo advantage. Pharm Dev Technol, 12:495-504.
25. Friedrich H, Fussnegger B, Kolter K, Bodmeier R. (2006). Dissolution rate improvement of poorly 6ffv02ater-soluble drugs obtained by adsorbing solutions of drugs in hydrophilic solvents onto high surface area carriers. Eur J Pharm Biopharm, 62:171-7.
26. Lee AR, Tojo K. (2001). An experimental approach to study the binding properties of vitamin E (alpha-tocopherol) during hairless mouse skin permeation. Chem Pharm Bull (Tokyo), 49:659-63.
27. Spielmann H, Hoffmann S, Liebsch M, Botham P, Fentem JH, Eskes C, et al. (2007). The ECVAM international validation study on in vitro tests for acute skin irritation: Report on the validity of the EPISKIN and EpiDerm assays and on the skin integrity function test. Altern Lab Anim, 35:559-601.
28. Validated Methods. (2006), http://ecvam.jrc.it/ [accessed October 28, 2008).
29. Levin J, Maibach H. (2005). The correlation bet6ffv02een transepidermal 6ffv02ater loss and percutaneous absorption: An overvie6ffv02. J Control Rel, 103:291-9. (Pubitemid 40342531)