Hydrogel-based piezoresistive biochemical microsensors

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 7642, Issue , 2010, Pages

  Guenther, Margarita ^a   Schulz, Volker ^a   Gerlach, Gerald ^a   Wallmersperger, Thomas ^b   Solzbacher, Florian ^c   Magda, Jules J ^d   Tathireddy, Prashant ^c   Lin, Genyao ^d   Orthner, Michael P ^c  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF STUTTGART   (Germany)

^c University of Utah   (United States)

^d UNIVERSITY OF UTAH   (United States)

Author keywords

Biochemical sensor; Glucose sensitive; pH sensitive; Piezoresistive sensor; Polyelectrolytic hydrogel; Swelling behaviour

Indexed keywords

ANALYTE CONCENTRATION; ANALYTES; AQUEOUS SOLUTIONS; BIOCHEMICAL SENSOR; BIOCOMPATIBLE POLYMER; CONTINUOUS MONITORING; FABRICATED SENSORS; GAMMA IRRADIATION; GEL SWELLING; GLUCOSE CONCENTRATION; GLUCOSE-SENSITIVE HYDROGEL; GRADUAL CHANGES; IMPLANTABLE SENSORS; MEASUREMENT PROCEDURES; ON-LINE CONTROLS; PH SENSITIVE; PHYSIOLOGICAL PH RANGE; PIEZO-RESISTIVE; PIEZORESISTIVE SENSORS; POLYELECTROLYTIC HYDROGELS; REPRODUCIBILITIES; SENSOR RESPONSE TIME; SENSOR SIGNALS; VOLUME PHASE TRANSITION;

ACTUATORS; CONDUCTING POLYMERS; ELECTRIC PROPERTIES; GELS; GLUCOSE; HYDROGELS; MEDICAL APPLICATIONS; MONITORING; ORGANIC POLYMERS; PH EFFECTS; PHASE TRANSITIONS; POLYMERS;

SENSORS;

EID: 77953234959     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.847373     Document Type: Conference Paper

References (21)

1. Wang, J., "Electrochemical glucose biosensors," Chem. Rev. 108, 814-825 (2008).
2. Lei, M., Baldi, A., Nuxoll, E., Siegel, R. A., Ziaie, B., "A hydrogel-based implantable micromachined transponder for wireless glucose measurement," Diabetes Techn & Therap. 8, 112-122 (2006).
3. Lei, M., Baldi, A., Nuxoll, E., Siegel, R. A., Ziaie, B., "Hydrogel-based microsensors for wireless chemical monitoring", Biomed Microdevices 11, 529-538 (2009), doi: 10.1007/s10544-008-9168-5.
4. Siegel, R. A., Gu, Y., Lei, M., Baldi, A., Nuxoll, E. E., Ziaie, B., "Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery," J. Controll. Release 141, 303-313 (2010).
5. Lin, G., Chang, S., Hao, H., Tathireddy, P., Orthner, M., Magda, J., Solzbacher, F., "Osmotic swelling pressure response of smart hydrogels suitable for chronically implantable glucose sensors," Sens. Actuat. B 144, 332-336 (2010).
6. Orthner, M. P., Lin, G., Avula, M., Buetefisch, S., Magda, J., Rieth, L. W., Solzbacher, F., "Hydrogel based sensor arrays (2x2) with perforated piezoresistive diaphragms for metabolic monitoring (in-vitro) ", Sens. Actuat. B (2010), doi: 10.1016/j.snb.2010.01.063.
7. Koschwanez, H. E., W. M. Reichert, W. M., "In vitro, in vivo and post explantation testing of glucose-detecting biosensors: current methods and recommendations, " Biomaterials 28, 3687-3703 (2007).
8. American Diabetes Association, "Standards of Medical Care: Correlation between A1C level and Mean Plasma Glucose Levels on Multiple Testing over 2-3 months, Table 6 and Table 7," Diabetes Care, supplement 1, 29, 51-580 (2006).
9. Gant, R. M., Abraham, A. A., Hou, Y., Cummins, B. M., Grunlan, M. A., Coté, G. L., "Design of a self-cleaning thermoresponsive nanocomposite hydrogel membrane for implantable biosensors," Acta Biomaterialia (2010), doi: 10.1016/j.actbio.2010.01.039.
10. Jung, D. Y., Magda, J. J., Han, I. S., "Catalase effects on glucose-sensitive hydrogels," Macromolecules 33, 3332-3336 (2000).
11. Orthner, M. P., Buetefisch S., Rieth, L. W., Magda, J., and Solzbacher, F., "Design, simulation and optimization of a novel piezoresistive pressure sensor with stress sensitive perforated diaphragm for wet sensing and hydrogel applications," IEEE Sensors J., (2010).
12. Arndt, K.-F., Richter, A., Ludwig, S., Zimmermann, J., Kressler, J., Kuckling, D., Adler, H.-J., "Poly(vinyl alcohol)/poly(acrylic acid) hydrogels: FT-IR spectroscopic characterization of crosslinking reaction and work at transition point," Acta Polymerica 50, 383-390 (1999).
13. Ivanov, A. E., Galaev, I. Y., Mattiasson, B., "Smart boronate-containing copolymers and gels at solid-liquid interfaces, cell, membranes, and tissues", [Smart polymers: applications in biotechnology and biomedicine], Galaev, I. and Mattiasson, B. (eds), 2nd ed., CRC Press, Boca Raton, London, New York, 299-329 (2008).
14. Yan, J., Springsteen, G., Deeter, S., Wang, B., "The relationship among pKa, pH, and binding constants in the interactions between boronic acids and diols - it is not as simple as it appears," Tetrahedron 60, 11205-11209 (2004). (Pubitemid 39425240)
15. Guenther, M., Gerlach, G., Corten, C., Kuckling, D., Sorber, J., Arndt, K.-F., "Hydrogel-based sensor for a rheochemical characterization of solutions," Sens. Actuat. B 132(2), 471-476 (2008).
16. Guenther, M., Gerlach, G., "Hydrogels for chemical sensors," [Hydrogel Sensors and Actuators], Gerlach, G., Arndt, K.-F. (eds.), Springer Series on Chemical Sensors and Biosensors, v. 6, Springer, Berlin Heidelberg, 165-195 (2009).
17. Guenther, M., Gerlach, G., Wallmersperger, T., "Piezoresistive biochemical sensors based on hydrogels," Microsystem Technologies (2010), doi: 10.1007/s00542-009-0978-z.
18. Ballhause, D. and Wallmersperger, T., "Coupled chemo-electro- mechanical finite element simulation of hydrogels: I. Chemical stimulation," Smart Mater. Struct. 17, 045011 (2008).
19. Wallmersperger, T. and Ballhause D., "Coupled chemo-electro- mechanical finite element simulation of hydrogels: II. Electrical stimulation," Smart Mater. Struct. 17, 045012 (2008).
20. Wallmersperger, T., "Modelling and simulation of the chemo-electro-mechanical behaviour, " [Hydrogel Sensors and Actuators], Gerlach, G., Arndt, K.-F. (eds.), Springer Series on Chemical Sensors and Biosensors, Springer, Berlin Heidelberg, v. 6, 137-163 (2009).
21. Wallmersperger, T., Ballhause, D., Kröplin, B., Günther, M., Gerlach, G., "Coupled multi-field formulation in space and time for the simulation of intelligent hydrogels, " J. Intel. Mater. Syst. and Struct. 20(12), 1483-1492 (2009).