Stimulus effects of three sulfur-containing psychoactive agents

Pharmacology Biochemistry and Behavior

Volumn 78, Issue 4, 2004, Pages 821-826

  Khorana, Nantaka ^a   Pullagurla, Manik R ^a   Dukat, Malgorzata ^a   Young, Richard ^a   Glennon, Richard A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

2C T 7; 4 MTA; Cocaine; DOM; Drug discrimination; Empathogens; Hallucinogens; MDMA; Stimulants

Indexed keywords

1 (4 METHYLTHIOPHENYL) 2 AMINOPROPANE; 2 (2,5 DIMETHOXY 4 N PROPYLTHIOPHENYL) 1 AMINOETHANE; 2,5 DIMETHOXY 4 METHYLAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALKANE DERIVATIVE; BENZENE DERIVATIVE; COCAINE; PHENYLALKYLAMINE; PSYCHEDELIC AGENT; PSYCHOTROPIC AGENT; SULFUR DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE; STRUCTURE ACTIVITY RELATION;

2,5-DIMETHOXY-4-METHYLAMPHETAMINE; ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; COCAINE; DISCRIMINATION (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; HALLUCINOGENS; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; PHENETHYLAMINES; PROPYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; STREET DRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; SULFUR;

EID: 3843077588     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2004.05.021     Document Type: Article

References (20)

1. Carmo H., Remiao F., Carvalho F., Fernandes E., de Boer D., dos Reys L.A., et al. 4-Methylthioamphetamine-induced hyperthermia in mice: influence of serotonergic and catecholaminergic pathways. Toxicol. Appl. Pharmacol. 190:2003;262-271
2. Carmo H., Hengstler J.G., de Boer D., Ringel M., Carvalho F., Fernandes E., et al. Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse. Naunyn-Schmiedebergs Arch. Pharmacol. 369:2004;198-205
3. Coop A. Biological evaluation of compounds for their physical dependence potential and abuse liability. Harris L.S. Annual and progress reports, problems of drug dependence. NIDA Res. Monogr. 181:2000;109-122
4. Cozzi N.V., Foley K.F. Methcathinone is a substrate for the serotonin uptake transporter. Pharmacol. Toxicol. 93:2003;219-225
5. Dukat M., Young R., Glennon R.A. Effect of PMA optical isomers and 4-MTA in PMMA-trained rats. Pharmacol. Biochem. Behav. 72:2002;299-305
6. International drug scheduling; Convention on psychotropic substances. Fed. Regist. 66:2001;13323-13326. (March 5)
7. Finney D. Probit analysis. 1952;Cambridge Univ. Press, London
8. Glennon R.A. Hallucinogens, stimulants, and related drugs of abuse. Williams D.A., Lemke T.L. Foye's principles of medicinal chemistry. 2002;434-452 Lippincott Williams & Wilkins, Philadelphia
9. Glennon R.A., Young R. Effect of 1-(3,4-methylenedioxyphenyl)-2- aminopropane and its optical isomers in PMMA-trained rats. Pharmacol. Biochem. Behav. 72:2002;307-311
10. 2 antagonists. Eur. J. Pharmacol. 91:1983;189-196
11. Glennon R.A., Titeler M., Lyon R.A. A preliminary investigation of the psychoactive agent 4-bromo-2,5-dimethoxyphenethylamine: a potential drug of abuse. Pharmacol. Biochem. Behav. 30:1988;597-601
12. Gobbi M., Moia M., Pirona L., Ceglia I., Reyes-Parada M., Scorza C., et al. p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro. J. Neurochem. 82:2002;1435-1443
13. Huang X., Marona-Lewicka D., Nichols D.E. p-Methylthioamphetamine is a potent new non-neurotoxic serotonin-releasing agent. Eur. J. Pharmacol. 229:1992;31-38
14. Hurtado-Guzman C., Fierro A., Iturrianga-Vasquez P., Sepulveda-Boza S., Cassels B.K., Reyes-Parada M. Monoamine oxidase inhibitory properties of optical isomers and N-substituted derivatives of 4-methylthioamphetamine. J. Enzyme Inhib. Med. Chem. 18:2003;339-347
15. Murphy J., Flynn J.J., Cannon D.M., Guiry P.J., McCormack P., Baird A.W., et al. In vitro neuronal and vascular responses to 5-hydroxytryptamine: modulation by 4-methylthioamphetamine, 4-methylthiomethamphetamine and 3,4-methylenedioxymethamphetamine. Eur. J. Pharmacol. 444:2002;61-67
16. Shulgin A., Shulgin A. Pihkal. 1991;Transform Press, Berkeley (CA)
17. Tandy K.P. Schedules of controlled substances: extension of temporary placement of N-benzylpiperazine (NBP), 1-(3-trifluoromethylphenyl)piperazine (TFMPP) and 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in Schedule I of the Controlled Substances Act. Fed. Regist. 68:2003;53289-53291. (September 10 and references therein)
18. Tandy K.P. Schedules of controlled substances: placement of 2,5-dimethoxy-4-(n)-propylthiophenylethylamine and N-benzylpiperazine into Schedule I of the controlled Substances Act. Final rule. Fed. Regist. 69:2004;12794-12797. (March 18)
19. Winstock A.R., Wolff K., Ramsey J. 4-MTA: a new synthetic drug on the dance scene. Drug Alcohol. Depend. 67:2002;111-115
20. Young R., Glennon R.A. Cocaine-stimulus generalization to MDA optical isomers: a reevaluation. Pharmacol. Biochem. Behav. 57:1997;115-118