Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth

Oncogene

Volumn 29, Issue 22, 2010, Pages 3297-3306

  Liu, Y ^a,b   Yan, S ^a   Wondimu, A ^a   Bob, D ^a   Weiss, M ^a   Sliwinski, K ^a   Villar, J ^c   Notario, V ^c   Sutherland, M ^a   Colberg Poley, A M ^a,b   Ladisch, S ^a,b  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

C Myc H Ras transformation; Ganglioside depletion; Ganglioside synthesis; Tumor model; Tumorigenesis

Indexed keywords

FIBRONECTIN; GANGLIOSIDE; GANGLIOSIDE GM2; GANGLIOSIDE GM3; GANGLIOSIDE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG; (N-ACETYLNEURAMINYL)-GALACTOSYLGLUCOSYLCERAMIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; HAEMATOSIDE SYNTHETASE; N ACETYLGALACTOSAMINYLTRANSFERASE; SIALYLTRANSFERASE;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; FIBROBLAST; KNOCKOUT GENE; KNOCKOUT MOUSE; LIPOGENESIS; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; TUMOR GROWTH; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL GROWTH; CELL MOTION; DEFICIENCY; GENETICS; HUMAN; METABOLISM; ONCOGENE MYC; ONCOGENE RAS; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CELL GROWTH PROCESSES; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; FIBROBLASTS; GANGLIOSIDES; GENES, MYC; GENES, RAS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; N-ACETYLGALACTOSAMINYLTRANSFERASES; ONCOGENES; SIALYLTRANSFERASES;

MURINAE; MUS;

EID: 77953231073     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.85     Document Type: Article

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