메뉴 건너뛰기




Volumn 54, Issue 2, 2010, Pages 92-98

Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels

Author keywords

Antibody; Diabetes; Dox; FACS; INSr Pdx1; Pancreas; Pdx1

Indexed keywords

CAPRA HIRCUS; MUS; ORYCTOLAGUS CUNICULUS; RATTUS; ROBERTSONIA;

EID: 77953169024     PISSN: 1121760X     EISSN: None     Source Type: Journal    
DOI: 10.4081/ejh.2010.e19     Document Type: Article
Times cited : (3)

References (40)
  • 1
    • 0028149890 scopus 로고
    • Insulin-Promoter-Factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-Promoter-Factor 1 is required for pancreas development in mice. Nature 1994;371:606-9.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 3
    • 0031031571 scopus 로고    scopus 로고
    • Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
    • Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 1997;15:106-10.
    • (1997) Nat Genet , vol.15 , pp. 106-110
    • Stoffers, D.A.1    Zinkin, N.T.2    Stanojevic, V.3    Clarke, W.L.4    Habener, J.F.5
  • 4
    • 0032525981 scopus 로고    scopus 로고
    • β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
    • Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H. β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev 1998;12:1763-8.
    • (1998) Genes Dev , vol.12 , pp. 1763-1768
    • Ahlgren, U.1    Jonsson, J.2    Jonsson, L.3    Simu, K.4    Edlund, H.5
  • 5
    • 24144479748 scopus 로고    scopus 로고
    • Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of β-cells in the adult pancreas
    • Holland AM, Gonez LJ, Naselli G, MacDonald RJ, Harrison LC. Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of β-cells in the adult pancreas. Diabetes 2005;54:2586-95.
    • (2005) Diabetes , vol.54 , pp. 2586-2595
    • Holland, A.M.1    Gonez, L.J.2    Naselli, G.3    Macdonald, R.J.4    Harrison, L.C.5
  • 6
    • 0026386775 scopus 로고
    • Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic α- and β-cells
    • Ohlsson H, Thor S, Edlund T. Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic α- and β-cells. Mol Endocrinol 1991;5:897-904.
    • (1991) Mol Endocrinol , vol.5 , pp. 897-904
    • Ohlsson, H.1    Thor, S.2    Edlund, T.3
  • 7
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson H, Karlsson K, Edlund T. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 1993;12:4251-9
    • (1993) EMBO J , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 9
    • 0031253820 scopus 로고    scopus 로고
    • Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
    • Stoffers D, Ferrer J, Clarke W, Habener J. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet 1997; 17:138-9.
    • (1997) Nat Genet , vol.17 , pp. 138-139
    • Stoffers, D.1    Ferrer, J.2    Clarke, W.3    Habener, J.4
  • 10
    • 0031775277 scopus 로고    scopus 로고
    • Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)
    • Øster A, Jensen J, Serup P, Galante P, Madsen OD, Larsson L-I. Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). J Histochem Cytochem 1998; 46:707-15.
    • (1998) J Histochem Cytochem , vol.46 , pp. 707-715
    • øster, A.1    Jensen, J.2    Serup, P.3    Galante, P.4    Madsen, O.D.5    Larsson, L.-I.6
  • 12
    • 38949149704 scopus 로고    scopus 로고
    • Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glu cose homeostasis
    • Gannon M, Ables ET, Crawford LLowe D, Offield MF, Magnuson MA et al. Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glu cose homeostasis. Dev Biol 2008;314;406-17.
    • (2008) Dev Biol , vol.314 , pp. 406-417
    • Gannon, M.1    Ables, E.T.2    Crawford LLowe, D.3    Offield, M.F.4    Magnuson, M.A.5
  • 14
    • 0030457705 scopus 로고    scopus 로고
    • Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor
    • Waeber G, Thompson N, Nicod P, Bonny C. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol 1996;10:1327-34.
    • (1996) Mol Endocrinol , vol.10 , pp. 1327-1334
    • Waeber, G.1    Thompson, N.2    Nicod, P.3    Bonny, C.4
  • 15
    • 0029812704 scopus 로고    scopus 로고
    • Induction of insulin and islet amyloid polypeptide prouction in pancreatic islet glucagonoma cells by insulin promoter factor 1
    • Serup P, Jensen J, Andersen FG, Jorgensen MC, Blume N, Holst JJ et al. Induction of insulin and islet amyloid polypeptide prouction in pancreatic islet glucagonoma cells by insulin promoter factor 1. PNAS 1996;93:9015-20.
    • (1996) PNAS , vol.93 , pp. 9015-9020
    • Serup, P.1    Jensen, J.2    Andersen, F.G.3    Jorgensen, M.C.4    Blume, N.5    Holst, J.J.6
  • 16
    • 10544239538 scopus 로고    scopus 로고
    • PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin
    • Watada H, Kajimoto Y, Miyagawa J, Hanafusa T, Hamaguchi K, Matsuoka T et al. PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes 1996;45: 1826-31.
    • (1996) Diabetes , vol.45 , pp. 1826-1831
    • Watada, H.1    Kajimoto, Y.2    Miyagawa, J.3    Hanafusa, T.4    Hamaguchi, K.5    Matsuoka, T.6
  • 17
    • 0027373441 scopus 로고
    • Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
    • Leonard J, Peers B, Johnson T, Ferreri K, Lee S, Montminy MR. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol 1993;7: 1275-83.
    • (1993) Mol Endocrinol , vol.7 , pp. 1275-1283
    • Leonard, J.1    Peers, B.2    Johnson, T.3    Ferreri, K.4    Lee, S.5    Montminy, M.R.6
  • 18
    • 0028314969 scopus 로고
    • IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
    • Miller CP, McGehee RE, Habener JF. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J 1994;13:1145-56.
    • (1994) EMBO J , vol.13 , pp. 1145-1156
    • Miller, C.P.1    McGehee, R.E.2    Habener, J.F.3
  • 19
    • 0031813431 scopus 로고    scopus 로고
    • An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2)
    • Swift GH, Liu Y, Rose SD, Bischof LJ, Steelman S, Buchberg AM et al. An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). Mol Cell Biol 1998;18:5109-20.
    • (1998) Mol Cell Biol , vol.18 , pp. 5109-5120
    • Swift, G.H.1    Liu, Y.2    Rose, S.D.3    Bischof, L.J.4    Steelman, S.5    Buchberg, A.M.6
  • 20
    • 0041856137 scopus 로고    scopus 로고
    • Functional, persistent, and extended liver to pancreas transdifferentiation
    • Ber I, Shternhall K, Perl S, Ohanuna Z, Goldberg I, Barshack I et al. Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem 2003;278: 31950-7.
    • (2003) J Biol Chem , vol.278 , pp. 31950-31957
    • Ber, I.1    Shternhall, K.2    Perl, S.3    Ohanuna, Z.4    Goldberg, I.5    Barshack, I.6
  • 21
    • 0035930629 scopus 로고    scopus 로고
    • The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene
    • Gerrish K, Cissell MA, Stein R. The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene. J Biol Chem 2001;276:47775-84.
    • (2001) J Biol Chem , vol.276 , pp. 47775-47784
    • Gerrish, K.1    Cissell, M.A.2    Stein, R.3
  • 23
    • 34247574265 scopus 로고    scopus 로고
    • Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets
    • Bergholdt R, Karlsen AE, Hagedorn PH, Aalund M, Nielsen JH, Kruhoffer M et al. Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets. Genes Immun 2007;8:232-8.
    • (2007) Genes Immun , vol.8 , pp. 232-238
    • Bergholdt, R.1    Karlsen, A.E.2    Hagedorn, P.H.3    Aalund, M.4    Nielsen, J.H.5    Kruhoffer, M.6
  • 24
    • 12944299798 scopus 로고    scopus 로고
    • Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity
    • Nielsen K, Kruhoffer M, Orntoft T, Sparre T, Wang H, Wollheim C et al. Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity. Diabetologia 2004;47:2185-99.
    • (2004) Diabetologia , vol.47 , pp. 2185-2199
    • Nielsen, K.1    Kruhoffer, M.2    Orntoft, T.3    Sparre, T.4    Wang, H.5    Wollheim, C.6
  • 25
    • 65249085779 scopus 로고    scopus 로고
    • AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells
    • Zhang X, Sun N, Wang L, Guo H, Guan Q, Cui B et al. AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells. J Cell Mol Med 2009;13:758-70.
    • (2009) J Cell Mol Med , vol.13 , pp. 758-770
    • Zhang, X.1    Sun, N.2    Wang, L.3    Guo, H.4    Guan, Q.5    Cui, B.6
  • 26
    • 17844368394 scopus 로고    scopus 로고
    • Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells
    • Wang H, Iezzi M, Theander S, Antinozzi PA, Gauthier BR, Halban PA et al. Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. Diabetologia 2005; 48:720-31.
    • (2005) Diabetologia , vol.48 , pp. 720-731
    • Wang, H.1    Iezzi, M.2    Theander, S.3    Antinozzi, P.A.4    Gauthier, B.R.5    Halban, P.A.6
  • 27
    • 0028567837 scopus 로고
    • Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
    • Peers B, Leonard J, Sharma S, Teitelman G, Montminy M. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol Endocrinol 1994;8:1798-806.
    • (1994) Mol Endocrinol , vol.8 , pp. 1798-1806
    • Peers, B.1    Leonard, J.2    Sharma, S.3    Teitelman, G.4    Montminy, M.5
  • 28
    • 0029763995 scopus 로고    scopus 로고
    • mRNA Profiling of rat islet tumors reveals Nkx 6.1 as a beta-cell-specific Homeodomain Transcription Factor
    • Jensen J, Serup P, Karlsen C, Nielsen TF, Madsen OD. mRNA Profiling of rat islet tumors reveals Nkx 6.1 as a beta-cell-specific Homeodomain Transcription Factor. J Biol Chem 1996; 271:18749-58.
    • (1996) J Biol Chem , vol.271 , pp. 18749-18758
    • Jensen, J.1    Serup, P.2    Karlsen, C.3    Nielsen, T.F.4    Madsen, O.D.5
  • 29
    • 0030448129 scopus 로고    scopus 로고
    • Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning
    • Larsson L-I, Madsen OD, Serup P, Jonsson J, Edlund H. Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning. Mech Dev 1996;60:175-84.
    • (1996) Mech Dev , vol.60 , pp. 175-184
    • Larsson, L.-I.1    Madsen, O.D.2    Serup, P.3    Jonsson, J.4    Edlund, H.5
  • 30
    • 0020678101 scopus 로고
    • Stable antibody-producing murine hybridomas
    • Taggart R, Samloff I. Stable antibody-producing murine hybridomas. Science 1983;219: 1228-30.
    • (1983) Science , vol.219 , pp. 1228-1230
    • Taggart, R.1    Samloff, I.2
  • 33
    • 34447097662 scopus 로고    scopus 로고
    • An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs
    • Ahnfelt-Ronne J, Jorgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sorensen J. An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. J Histochem Cytochem 2007;55:925-30.
    • (2007) J Histochem Cytochem , vol.55 , pp. 925-930
    • Ahnfelt-Ronne, J.1    Jorgensen, M.C.2    Hald, J.3    Madsen, O.D.4    Serup, P.5    Hecksher-Sorensen, J.6
  • 34
    • 0025374590 scopus 로고
    • Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells
    • D'Ambra R, Surana M, Efrat S, Starr R, Fleischer N. Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells. Endocrinology 1990;126:2815-22.
    • (1990) Endocrinology , vol.126 , pp. 2815-2822
    • D'Ambra, R.1    Surana, M.2    Efrat, S.3    Starr, R.4    Fleischer, N.5
  • 35
    • 0025269469 scopus 로고
    • Comparison of cytokine effects on mouse pancreatic alpha-cell and beta-cell lines. Viability, secretory function, and MHC antigen expression
    • Hamaguchi K, Leiter E. Comparison of cytokine effects on mouse pancreatic alpha-cell and beta-cell lines. Viability, secretory function, and MHC antigen expression. Diabetes 1990;39:415-25.
    • (1990) Diabetes , vol.39 , pp. 415-425
    • Hamaguchi, K.1    Leiter, E.2
  • 36
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 37
    • 10644229209 scopus 로고    scopus 로고
    • Generation of monoclonal antibodies against mouse neurogenin 3: A new immunocytochemical tool to study the pancreatic endocrine progenitor cell
    • Zahn S, Hecksher-Sorensen J, Pedersen IL, Serup P, Madsen O. Generation of monoclonal antibodies against mouse neurogenin 3: a new immunocytochemical tool to study the pancreatic endocrine progenitor cell. Hybrid Hybridomics. 2004;23:385-8.
    • (2004) Hybrid Hybridomics , vol.23 , pp. 385-388
    • Zahn, S.1    Hecksher-Sorensen, J.2    Pedersen, I.L.3    Serup, P.4    Madsen, O.5
  • 38
    • 43949111010 scopus 로고    scopus 로고
    • Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development
    • Hald J, Sprinkel AE, Ray M, Serup P, Wright C, Madsen OD. Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development. J Histochem Cytochem 2008;56:587-95.
    • (2008) J Histochem Cytochem , vol.56 , pp. 587-595
    • Hald, J.1    Sprinkel, A.E.2    Ray, M.3    Serup, P.4    Wright, C.5    Madsen, O.D.6
  • 39
    • 0037066694 scopus 로고    scopus 로고
    • Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding
    • Chakrabarti SK, James JC, Mirmira RG. Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. J Biol Chem 2002;277:13286-93.
    • (2002) J Biol Chem , vol.277 , pp. 13286-13293
    • Chakrabarti, S.K.1    James, J.C.2    Mirmira, R.G.3
  • 40
    • 36148986076 scopus 로고    scopus 로고
    • Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy
    • Keller DM, McWeeney S, Arsenlis A, Drouin J, Wright CV, Wang H et al. Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem 2007;282:32084-92.
    • (2007) J Biol Chem , vol.282 , pp. 32084-32092
    • Keller, D.M.1    McWeeney, S.2    Arsenlis, A.3    Drouin, J.4    Wright, C.V.5    Wang, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.