메뉴 건너뛰기




Volumn 108, Issue 6, 2010, Pages 1641-1650

Pulmonary O2 uptake and leg blood flow kinetics during moderate exercise are slowed by hyperventilation-induced hypocapnic alkalosis

Author keywords

Doppler ultrasound; Near infrared spectroscopy; Oxygen uptake kinetics; Respiratory alkalosis

Indexed keywords

ADULT; ARTICLE; BLOOD FLOW VELOCITY; EXERCISE; HUMAN; HYPERVENTILATION; HYPOCAPNIA; KINETICS; LEG; LUNG; MALE; PATHOPHYSIOLOGY; RESPIRATORY ALKALOSIS; VASCULARIZATION;

EID: 77953158828     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01346.2009     Document Type: Article
Times cited : (19)

References (73)
  • 1
    • 33748416868 scopus 로고    scopus 로고
    • Blood lactate accumulation: Hemodynamics and acid base status
    • Aduen JF, Burritt MF, Murray MJ. Blood lactate accumulation: Hemodynamics and acid base status. J Intensive Care Med 17: 180-185, 2002.
    • (2002) J Intensive Care Med , vol.17 , pp. 180-185
    • Aduen, J.F.1    Burritt, M.F.2    Murray, M.J.3
  • 2
    • 0028789331 scopus 로고
    • The effects of extracellular pH and calcium change on force and intracellular calcium, in rat vascular smooth muscle
    • Austin C, Wray S. The effects of extracellular pH and calcium change on force and intracellular calcium, in rat vascular smooth muscle. J Physiol 488: 281-291, 1995.
    • (1995) J Physiol , vol.488 , pp. 281-291
    • Austin, C.1    Wray, S.2
  • 3
    • 0028224605 scopus 로고
    • A quantitative study of the relation between intracellular pH and force in rat mesenteric vascular smooth muscle
    • DOI 10.1007/BF00374534
    • Austin C, Wray S. A quantitative study of the relation between, intracellular pH and force in rat mesenteric vascular smooth muscle. Pflügers Arch 427: 270-276, 1994. (Pubitemid 24160363)
    • (1994) Pflugers Archiv European Journal of Physiology , vol.427 , Issue.3-4 , pp. 270-276
    • Austin, C.1    Wray, S.2
  • 4
    • 0033976520 scopus 로고    scopus 로고
    • + and functional consequences in vascular smooth muscle
    • + and functional consequences in vascular smooth muscle. Circ Res 86: 355-363, 2000.
    • (2000) Circ Res , vol.86 , pp. 355-363
    • Austin, C.1    Wray, S.2
  • 6
    • 0034058855 scopus 로고    scopus 로고
    • Resolution of smooth muscle and endothelial pathways for conduction along hamster cheek pouch arterioles
    • Bartlett IS, Segal SS. Resolution of smooth muscle and endothelial pathways for conduction along hamster cheek pouch arterioles. Am J Physiol Heart Circ Physiol 278: H604-H612, 2000.
    • (2000) Am J Physiol Heart Circ Physiol , vol.278
    • Bartlett, I.S.1    Segal, S.S.2
  • 7
    • 0027516250 scopus 로고
    • Cytosolic free calcium regulation in response to acute changes in intracellular pH in vascular smooth muscle
    • Batlle DC, Peces R, LaPointe MS, Ye M, Daugirdas JT. Cytosolic free calcium regulation in response to acute changes in intracellular pH in vascular smooth muscle. Am J Physiol Cell Physiol 264: C932-C943, 1993.
    • (1993) Am J Physiol Cell Physiol , vol.264
    • Batlle, D.C.1    Peces, R.2    Lapointe, M.S.3    Ye, M.4    Daugirdas, J.T.5
  • 10
    • 0014556937 scopus 로고
    • 2 washout during hyperventilation in man
    • 2 washout during hyperventilation in man. Respir Physiol 1: 163-172, 1969.
    • (1969) Respir Physiol , vol.1 , pp. 163-172
    • Brandi, G.1    Clode, M.2
  • 11
    • 0021854652 scopus 로고
    • Effect of respiratory alkalosis on skeletal muscle metabolism in the dog
    • Brice AG, Welch HG. Effect of respiratory alkalosis on skeletal muscle metabolism in the dog. J Appl Physiol 58: 658-664, 1985. (Pubitemid 15063658)
    • (1985) Journal of Applied Physiology , vol.58 , Issue.2 , pp. 658-664
    • Brice, A.G.1    Welch, H.G.2
  • 12
    • 0002550937 scopus 로고
    • The effect of hypocapnia on arterial blood pressure
    • Burnum JF, Hickam JB, Mcintosh HD. The effect of hypocapnia on arterial blood pressure. Circulation 9: 89-95, 1954.
    • (1954) Circulation , vol.9 , pp. 89-95
    • Burnum, J.F.1    Hickam, J.B.2    Mcintosh, H.D.3
  • 15
    • 0029841675 scopus 로고    scopus 로고
    • Gap junctions in vascular tissues: Evaluating the role of intercellular communication in the modulation of vasomotor tone
    • Christ GJ, Spray DC, El-Sabban M, Moore LK, Brink PR. Gap junctions in vascular tissues: evaluating the role of intercellular communication in the modulation of vasomotor tone. Circ Res 79: 631-646, 1996. (Pubitemid 26317811)
    • (1996) Circulation Research , vol.79 , Issue.4 , pp. 631-646
    • Christ, G.J.1    Spray, D.C.2    El-Sabban, M.3    Moore, L.K.4    Brink, P.R.5
  • 16
    • 9044236313 scopus 로고
    • The effect of voluntary overbreathing on the blood flow through the human forearm
    • Clarke RSJ. The effect of voluntary overbreathing on the blood flow through the human forearm. J Physiol 118: 537-544, 1952.
    • (1952) J Physiol , vol.118 , pp. 537-544
    • Clarke, R.S.J.1
  • 17
    • 0013974673 scopus 로고
    • Hyperventilation and human calf blood flow
    • Coffman JD, Kelly P. Hyperventilation and human calf blood flow. Am J Physiol 211: 1255-1260, 1966.
    • (1966) Am J Physiol , vol.211 , pp. 1255-1260
    • Coffman, J.D.1    Kelly, P.2
  • 18
    • 0033920618 scopus 로고    scopus 로고
    • Remote arteriolar dilations in response to muscle contraction under capillaries
    • Cohen KD, Berg BR, Sarelius IH. Remote arteriolar dilations in response to muscle contraction under capillaries. Am J Physiol Heart Circ Physiol 278: H1916-H1923, 2000.
    • (2000) Am J Physiol Heart Circ Physiol , vol.278
    • Cohen, K.D.1    Berg, B.R.2    Sarelius, I.H.3
  • 19
    • 0031843694 scopus 로고    scopus 로고
    • Conducted vascular responses: Communication across the capillary bed
    • Collins DM, McCullough WT, Ellsworth ML. Conducted vascular responses: communication across the capillary bed. Microvasc Res 56: 43-53, 1998.
    • (1998) Microvasc Res , vol.56 , pp. 43-53
    • Collins, D.M.1    McCullough, W.T.2    Ellsworth, M.L.3
  • 20
    • 0024504059 scopus 로고
    • Effects of intracellular alkalinization on resting and agonist-induced vascular tone
    • Danthuluri NR, Deth RC. Effects of intracellular alkalinization on resting and agonist-induced vascular tone. Am J Physiol Heart Circ Physiol 256: H867-H875, 1989.
    • (1989) Am J Physiol Heart Circ Physiol , vol.256
    • Danthuluri, N.R.1    Deth, R.C.2
  • 21
    • 0038309423 scopus 로고    scopus 로고
    • 2 uptake kinetics and muscle deoxygenation during moderate-intensity exercise
    • 2 uptake kinetics and muscle deoxygenation during moderate-intensity exercise. J Appl Physiol 95: 113-120, 2003.
    • (2003) J Appl Physiol , vol.95 , pp. 113-120
    • Delorey, D.S.1    Kowalchuk, J.M.2    Paterson, D.H.3
  • 24
    • 0033974102 scopus 로고    scopus 로고
    • Endothelial cell pathway for conduction of hyperpolarization and vasodilation along hamster feed artery
    • Emerson GG, Segal SS. Endothelial cell pathway for conduction of hyperpolarization and vasodilation along hamster feed artery. Circ Res 86: 94-100, 2000.
    • (2000) Circ Res , vol.86 , pp. 94-100
    • Emerson, G.G.1    Segal, S.S.2
  • 26
    • 34147104563 scopus 로고    scopus 로고
    • Effects of hyperventilation, on phosphocreatine kinetics and muscle deoxygenation during moderate-intensity plantar flexion exercise
    • Forbes SC, Kowalchuk JM, Thompson RT, Marsh GD. Effects of hyperventilation, on phosphocreatine kinetics and muscle deoxygenation during moderate-intensity plantar flexion exercise. J Appl. Physiol 102: 1565-1573, 2007.
    • (2007) J Appl. Physiol , vol.102 , pp. 1565-1573
    • Forbes, S.C.1    Kowalchuk, J.M.2    Thompson, R.T.3    Marsh, G.D.4
  • 27
    • 0024518382 scopus 로고
    • And hyperventilation substantially attenuate vagal tone in normal volunteers A. possible mechanism of panic provocation?
    • George DT, Nutt DJ, Walker WV, Porges SW, Adinoff B, Linnoila M. Lactate and hyperventilation substantially attenuate vagal tone in normal volunteers: A. possible mechanism of panic provocation? Arch Gen Psychiatry 46: 153-156, 1989.
    • (1989) Arch Gen Psychiatry , vol.46 , pp. 153-156
    • George, D.T.1    Nutt, D.J.2    Walker, W.V.3    Porges, S.W.4    Linnoila, A.B.5    Lactate, M.6
  • 29
    • 77953154365 scopus 로고    scopus 로고
    • An integrative approach to control of oxidative phosphorylation during exercise
    • Gurd BJ, Heigenhauser GJF, Paterson DH, Kowalchuk JM. An integrative approach to control of oxidative phosphorylation during exercise. Physiol News 69: 36-38, 2007.
    • (2007) Physiol News , vol.69 , pp. 36-38
    • Gurd, B.J.1    Heigenhauser, G.J.F.2    Paterson, D.H.3    Kowalchuk, J.M.4
  • 31
    • 0027583688 scopus 로고
    • The effect of hypocapnia on skeletal muscle microcirculatory blood flow, oxygenation and pH
    • Gustafsson U, Sjoberg F, Lewis DH, Thorborg P. The effect of hypocapnia on skeletal muscle microcirculatory blood flow, oxygenation and pH. Int J Microcirc Clin Exp 12: 131-141, 1993.
    • (1993) Int J Microcirc Clin Exp , vol.12 , pp. 131-141
    • Sjoberg, F.1    Lewis, D.H.2    Thorborg, P.3
  • 32
    • 33745363488 scopus 로고    scopus 로고
    • Human femoral artery and estimated muscle capillary blood flow kinetics following the onset of exercise
    • Harper AJ, Ferreira LF, Lutjemeier BJ, Townsend DK, Barstow TJ. Human femoral artery and estimated muscle capillary blood flow kinetics following the onset of exercise. Exp Physiol 91: 661-671, 2006.
    • (2006) Exp Physiol , vol.91 , pp. 661-671
    • Harper, A.J.1    Ferreira, L.F.2    Lutjemeier, B.J.3    Townsend, D.K.4    Barstow, T.J.5
  • 35
    • 0026610924 scopus 로고
    • 2 transport and its interaction with metabolism; a systems view of aerobic capacity
    • 2 transport and its interaction with metabolism; a systems view of aerobic capacity. Med Sci Sports Exerc 24: 47-53, 1992.
    • (1992) Med Sci Sports Exerc , vol.24 , pp. 47-53
    • Honig, C.R.1    Connett, R.J.2    Gayeski, T.E.3
  • 37
    • 0030933001 scopus 로고    scopus 로고
    • Lactate-proton cotransport in skeletal muscle
    • Juel C. Lactate-proton cotransport in skeletal muscle. Physiol Rev 11: 321-358, 1997.
    • (1997) Physiol Rev , vol.11 , pp. 321-358
    • Juel, C.1
  • 40
    • 34548214669 scopus 로고    scopus 로고
    • Permissive range of hypercapnia for improved peripheral microcirculation and cardiac output in rabbits
    • Komori M, Takada K, Tomizawa Y, Nishiyama K, Kawamata M, Ozaki M. Permissive range of hypercapnia for improved peripheral microcirculation and cardiac output in rabbits. Crit Care Med 35: 2171-2175, 2007.
    • (2007) Crit Care Med , vol.35 , pp. 2171-2175
    • Komori, M.1    Takada, K.2    Tomizawa, Y.3    Nishiyama, K.4    Kawamata, M.5    Ozaki, M.6
  • 44
    • 0023260998 scopus 로고    scopus 로고
    • Effect of interbreath fluctuations on characterizing exercise gas exchange kinetics
    • Lamarra N, Whipp BJ, Ward SA, Wasserman K. Effect of interbreath fluctuations on characterizing exercise gas exchange kinetics. J Appl Physiol. 62: 2003-2012, 1987.
    • (2003) J Appl Physiol. , vol.62 , Issue.2012 , pp. 1987
    • Lamarra, N.1    Whipp, B.J.2    Ward, S.A.3    Wasserman, K.4
  • 45
    • 0036793162 scopus 로고    scopus 로고
    • Effects of respiratory alkalosis on human skeletal muscle metabolism at the onset of submaximal exercise
    • LeBlanc PJ, Parolin ML, Jones NL, Heigenhauser GJ. Effects of respiratory alkalosis on human skeletal muscle metabolism at the onset of submaximal exercise. J Physiol 544: 303-313, 2002.
    • (2002) J Physiol , vol.544 , pp. 303-313
    • Leblanc, P.J.1    Parolin, M.L.2    Jones, N.L.3    Heigenhauser, G.J.4
  • 46
    • 0013338285 scopus 로고
    • The blood flow in the brain and the leg of man, and the changes induced by alteration of blood gases
    • Lennox WG, Gibbs EL. The blood flow in the brain and the leg of man, and the changes induced by alteration of blood gases. J Clin Invest 11: 1155-1177, 1932.
    • (1932) J Clin Invest , vol.11 , pp. 1155-1177
    • Lennox, W.G.1    Gibbs, E.L.2
  • 47
    • 0031770681 scopus 로고    scopus 로고
    • Alveolar oxygen, uptake and femoral artery blood flow dynamics in upright and supine leg exercise in humans
    • MacDonald MJ, Shoemaker JK, Tschakovsky ME, Hughson RL. Alveolar oxygen, uptake and femoral artery blood flow dynamics in upright and supine leg exercise in humans. J Appl Physiol 85: 1622-1628, 1998.
    • (1998) J Appl Physiol , vol.85 , pp. 1622-1628
    • MacDonald, M.J.1    Shoemaker, J.K.2    Tschakovsky, M.E.3    Hughson, R.L.4
  • 48
    • 0033969826 scopus 로고    scopus 로고
    • Effect of hyperoxia and hypoxia on leg blood flow and pulmonary and leg oxygen uptake at the onset of kicking exercise
    • MacDonald MJ, Tarnopolsky MA, Hughson RL. Effect of hyperoxia and hypoxia on leg blood flow and pulmonary and leg oxygen uptake at the onset of kicking exercise. Can J Physiol Pharmacol 78: 67-74, 2000.
    • (2000) Can J Physiol Pharmacol , vol.78 , pp. 67-74
    • MacDonald, M.J.1    Tarnopolsky, M.A.2    Hughson, R.L.3
  • 49
    • 27544487060 scopus 로고    scopus 로고
    • 2 uptake, leg blood flow, and muscle deoxygenation are slowed in the upper compared with lower region of the moderate-intensity exercise domain
    • 2 uptake, leg blood flow, and muscle deoxygenation are slowed in the upper compared with lower region of the moderate-intensity exercise domain. J Appl Physiol 99: 1822-1834, 2005.
    • (2005) J Appl Physiol , vol.99 , pp. 1822-1834
    • MacPhee, S.L.1    Shoemaker, J.K.2    Paterson, D.H.3    Kowalchuk, J.M.4
  • 50
    • 0026611662 scopus 로고
    • i and tension in isolated rat mesenteric resistance arteries
    • i and tension in isolated rat mesenteric resistance arteries. J Vase Res 29: 330-340, 1992.
    • (1992) J Vase Res , vol.29 , pp. 330-340
    • Matthews, J.G.1    Graves, J.E.2    Poston, L.3
  • 51
    • 0030040995 scopus 로고    scopus 로고
    • Mechanism of lactate-induced relaxation of isolated rat mesenteric resistance arteries
    • McKinnon W, Aaronson PI, Knock G, Graves J, Poston L. Mechanism of lactate-induced relaxation, of isolated rat mesenteric resistance arteries. J Physiol 490: 783-792, 1996. (Pubitemid 26058848)
    • (1996) Journal of Physiology , vol.490 , Issue.3 , pp. 783-792
    • McKinnon, W.1    Aaronson, P.I.2    Knock, G.3    Graves, J.4    Poston, L.5
  • 53
    • 0029294654 scopus 로고
    • Influence of microvascular architecture on oxygen exchange in skeletal muscle
    • Pittman RN. Influence of microvascular architecture on oxygen exchange in skeletal muscle. Microcirculation 2: 1-18, 1995.
    • (1995) Microcirculation , vol.2 , pp. 1-18
    • Pittman, R.N.1
  • 55
    • 1842293325 scopus 로고    scopus 로고
    • Ultrasound doppler estimates of femoral artery blood flow during dynamic knee extensor exercise in humans
    • Radegran G. Ultrasound Doppler estimates of femoral artery blood flow during dynamic knee extensor exercise in humans. J Appl Physiol 83: 1383-1388, 1997. (Pubitemid 27433108)
    • (1997) Journal of Applied Physiology , vol.83 , Issue.4 , pp. 1383-1388
    • Radegran, G.1
  • 57
    • 0003116178 scopus 로고
    • General and regional circulatory responses to change in blood pH and carbon dioxide tension
    • Richardson DW, Wasserman AJ, Patterson JL Jr. General and regional circulatory responses to change in blood pH and carbon dioxide tension. J Clin Invest 40: 3.1-43, 1961.
    • (1961) J Clin Invest , vol.40 , pp. 31-43
    • Richardson, D.W.1    Wasserman, A.J.2    Patterson Jr., J.L.3
  • 58
    • 0344434045 scopus 로고
    • Humoral vasodilatation in the forearm during voluntary hyperventilation
    • Roddie IC, Shepherd JT, Whelan RF. Humoral vasodilatation in the forearm during voluntary hyperventilation. J Physiol 137: 80-85, 1957.
    • (1957) J Physiol , vol.137 , pp. 80-85
    • Roddie, I.C.1    Shepherd, J.T.2    Whelan, R.F.3
  • 60
    • 0025082956 scopus 로고
    • Reflex control of the circulation during exercise: Chemoreflexes and mechanoreflexes
    • Rowell LB, O'Leary DS. Reflex control of the circulation during exercise: chemoreflexes and mechanoreflexes. J Appl Physiol 69: 407-418, 1990.
    • (1990) J Appl Physiol , vol.69 , pp. 407-418
    • Rowell, L.B.1    O'Leary, D.S.2
  • 61
    • 0345854724 scopus 로고    scopus 로고
    • The aging cardiovascular system.: Changes in autonomic function at rest and in response to exercise
    • Seals DR, Monahan KD, Bell C, Tanaka H, Jones PP. The aging cardiovascular system.: changes in autonomic function at rest and in response to exercise. Int J Sport Nutr Exerc Metab 1.1: 189-195, 2001.
    • (2001) Int J Sport Nutr Exerc Metab , vol.11 , pp. 189-195
    • Seals, D.R.1    Monahan, K.D.2    Bell, C.3    Tanaka, H.4    Jones, P.P.5
  • 62
    • 0024565181 scopus 로고
    • Conduction of vasomotor responses in arterioles a role for cell-to-cell coupling?
    • Segal SS, Duling BR. Conduction of vasomotor responses in arterioles: A role for cell-to-cell coupling? Am J Physiol. Heart Circ Physiol. 256: H838-H845, 1989.
    • (1989) Am J Physiol. Heart Circ Physiol. , vol.256
    • Segal, S.S.1    Duling, B.R.2
  • 65
    • 0036220628 scopus 로고    scopus 로고
    • Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise
    • Spriet LL, Heigenhauser GJ. Regulation of pyruvate dehydrogenase (PDH) activity in human, skeletal muscle during exercise. Exerc Sport Sci Rev 30: 91-95, 2002. (Pubitemid 34298811)
    • (2002) Exercise and Sport Sciences Reviews , vol.30 , Issue.2 , pp. 91-95
    • Spriet, L.L.1    Heigenhauser, G.J.F.2
  • 66
    • 0023605871 scopus 로고
    • Phosphorus nuclear magnetic resonance study of metabolites and intracellular pH in rabbit vascular smooth muscle
    • Spurway NC, Wray S. A. phosphorus nuclear magnetic resonance study of metabolites and intracellular pH in rabbit vascular smooth muscle. J Physiol 393: 57-71, 1987.
    • (1987) J Physiol , vol.393 , pp. 57-71
    • Spurway, N.C.1    Wray, S.A.2
  • 67
    • 0029073630 scopus 로고
    • Lesser vagal withdrawal during isometric exercise with age
    • Taylor JA, Hayano J, Seals DR. Lesser vagal withdrawal during isometric exercise with age. J Appl Physiol 79: 805-811, 1995.
    • (1995) J Appl Physiol , vol.79 , pp. 805-811
    • Taylor, J.A.1    Hayano, J.2    Seals, D.R.3
  • 68
    • 0032938841 scopus 로고    scopus 로고
    • Interaction of factors determining oxygen uptake at the onset of exercise
    • Tschakovsky ME, Hughson RL. Interaction of factors determining oxygen uptake at the onset of exercise. J Appl Physiol. 86: 1101-1113, 1999.
    • (1999) J Appl Physiol. , vol.86 , pp. 1101-1113
    • Tschakovsky, M.E.1    Hughson, R.L.2
  • 69
    • 3242719446 scopus 로고    scopus 로고
    • Immediate exercise hyperemia: Contributions of the muscle pump vs. rapid vasodilation
    • DOI 10.1152/japplphysiol.00185.2004
    • Tschakovsky ME, Sheriff DD. Immediate exercise hyperemia: contributions of the muscle pump vs. rapid vasodilation. J Appl Physiol 97: 739-747, 2004. (Pubitemid 38963149)
    • (2004) Journal of Applied Physiology , vol.97 , Issue.2 , pp. 739-747
    • Tschakovsky, M.E.1    Sheriff, D.D.2
  • 71
    • 33751304198 scopus 로고    scopus 로고
    • Coactivation of resistance vessels and muscle fibers with acetylcholine release from motor nerves
    • Welsh DG, Segal SS. Coactivation of resistance vessels and muscle fibers with acetylcholine release from motor nerves. Am J Physiol. Heart Circ. Physiol 273: H156-H163, 1997.
    • (1997) Am J Physiol. Heart Circ. Physiol , vol.273
    • Welsh, D.G.1    Segal, S.S.2
  • 72
    • 33750888832 scopus 로고    scopus 로고
    • Endothelial and smooth muscle cell conduction in arterioles controlling blood flow
    • Welsh DG, Segal SS. Endothelial and smooth muscle cell conduction in arterioles controlling blood flow. Am J Physiol Heart Circ Physiol 274: H178-H186, 1998.
    • (1998) Am J Physiol Heart Circ Physiol , vol.274
    • Welsh, D.G.1    Segal, S.S.2
  • 73
    • 4544351213 scopus 로고    scopus 로고
    • Mechanisms of action of pH-induced effects on vascular smooth muscle
    • DOI 10.1023/B:MCBI.0000041858.78005.d2
    • Wray S, Smith RD. Mechanisms of action of pH-induced effects on vascular smooth muscle. Mol Cell Biochem 263: 163-172, 2004. (Pubitemid 39256155)
    • (2004) Molecular and Cellular Biochemistry , vol.263 , Issue.1 , pp. 163-172
    • Wray, S.1    Smith, R.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.