Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays

Clinical and Vaccine Immunology

Volumn 17, Issue 6, 2010, Pages 993-1004

  Geluk, Annemieke ^a   Van Der Ploeg Van Schip, Jolien J ^a   Van Meijgaarden, Krista E ^a   Commandeur, Susanna ^a   Drijfhout, Jan W ^a   Benckhuijsen, Willemien E ^a   Franken, Kees L M C ^a   Naafs, Bernard ^a   Ottenhoff, Tom H M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEPTIDE;

ARTICLE; ASSAY; BLOOD ANALYSIS; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; MYCOBACTERIUM LEPRAE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SAMPLE;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CYTOKINES; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-12; LEPROSY; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM LEPRAE; PEPTIDES; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; T-LYMPHOCYTES;

EID: 77953156068     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00046-10     Document Type: Article

References (35)

1. Reference deleted.
2. Araoz, R., N. Honore, S. Banu, C. Demangel, Y. Cissoko, C. Arama, M. K. Uddin, S. K. Hadi, M. Monot, S. N. Cho, B. Ji, P. J. Brennan, S. Sow, and S. T. Cole. 2006. Towards an immunodiagnostic test for leprosy. Microbes Infect. 8:2270-2276.
3. Beveridge, N. E., H. A. Fletcher, J. Hughes, A. A. Pathan, T. J. Scriba, A. Minassian, C. R. Sander, K. T. Whelan, H. M. Dockrell, A. V. Hill, W. A. Hanekom, and H. McShane. 2008. A comparison of IFNgamma detection methods used in tuberculosis vaccine trials. Tuberculosis (Edinburgh) 88:631-640.
4. Black, G. F., R. E. Weir, S. Floyd, L. Bliss, D. K. Warndorff, A. C. Crampin, B. Ngwira, L. Sichali, B. Nazareth, J. M. Blackwell, K. Branson, S. D. Chaguluka, L. Donovan, E. Jarman, E. King, P. E. Fine, and H. M. Dockrell. 2002. BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies. Lancet 359:1393-1401.
5. Cole, S. T., K. Eiglmeier, J. Parkhill, K. D. James, N. R. Thomson, P. R. Wheeler, N. Honore, T. Garnier, C. Churcher, D. Harris, K. Mungall, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. M. Davies, K. Devlin, S. Duthoy, T. Feltwell, A. Fraser, N. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, C. Lacroix, J. Maclean, S. Moule, L. Murphy, K. Oliver, M. A. Quail, M. A. Rajandream, K. M. Rutherford, S. Rutter, K. Seeger, S. Simon, M. Simmonds, J. Skelton, R. Squares, S. Squares, K. Stevens, K. Taylor, S. Whitehead, J. R. Woodward, and B. G. Barrell. 2001. Massive gene decay in the leprosy bacillus. Nature 409:1007-1011.
6. de Jong, R., A. A. Janson, W. R. Faber, B. Naafs, and T. H. Ottenhoff. 1997. IL-2 and IL-12 act in synergy to overcome antigen-specific T cell unresponsiveness in mycobacterial disease. J. Immunol. 159:786-793.
7. Denis, M., D. N. Wedlock, A. R. McCarthy, N. A. Parlane, P. J. Cockle, H. M. Vordermeier, R. G. Hewinson, and B. M. Buddle. 2007. Enhancement of the sensitivity of the whole blood interferon-gamma assay for increasing detection of Mycobacterium bovis-infected cattle. Clin. Vaccine Immunol. 14:1483-1489.
8. Dockrell, H. M., G. F. Black, R. E. Weir, and P. E. Fine. 2000. Whole blood assays for interferon-gamma: practicalities and potential for use as diagnostic tests in the field. Lepr. Rev. 71(Suppl.):S60-S62.
9. Dockrell, H. M., S. Brahmbhatt, B. D. Robertson, S. Britton, U. Fruth, N. Gebre, M. Hunegnaw, R. Hussain, R. Manandhar, L. Murillo, M. C. Pessolani, P. Roche, J. L. Salgado, E. Sampaio, F. Shahid, J. E. Thole, and D. B. Young. 2000. A postgenomic approach to identification of Mycobacterium leprae-specific peptides as T-cell reagents. Infect. Immun. 68:5846-5855.
10. Duthie, M. S., W. Goto, G. C. Ireton, S. T. Reece, L. H. Sampaio, A. B. Grassi, A. L. Sousa, C. M. Martelli, M. M. Stefani, and S. G. Reed. 2008. Antigen-specific T-cell responses of leprosy patients. Clin. Vaccine Immunol. 15:1659-1665.
11. Ferrara, G., M. Losi, R. D'Amico, P. Roversi, R. Piro, M. Meacci, B. Meccugni, I. M. Dori, A. Andreani, B. M. Bergamini, C. Mussini, F. Rumpianesi, L. M. Fabbri, and L. Richeldi. 2006. Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study. Lancet 367:1328-1334.
12. Feske, M., R. J. Nudelman, M. Medina, J. Lew, M. Singh, J. Couturier, E. A. Graviss, and D. E. Lewis. 2008. Enhancement of human antigen-specific memory T-cell responses by interleukin-7 may improve accuracy in diagnosing tuberculosis. Clin. Vaccine Immunol. 15:1616-1622.
13. Flynn, J. L., M. M. Goldstein, K. J. Triebold, J. Sypek, S. Wolf, and B. R. Bloom. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J. Immunol. 155:2515-2524.
14. Franken, K. L., H. S. Hiemstra, K. E. van Meijgaarden, Y. Subronto, J. den Hartigh, T. H. Ottenhoff, and J. W. Drijfhout. 2000. Purification of histagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent. Protein Expr. Purif. 18:95-99.
15. Fuhrmann, S., M. Streitz, and F. Kern. 2008. How flow cytometry is changing the study of TB immunology and clinical diagnosis. Cytometry A 73:1100-1106.
16. Geluk, A., J. Ploeg, R. O. Teles, K. L. Franken, C. Prins, J. W. Drijfhout, E. N. Sarno, E. P. Sampaio, and T. H. Ottenhoff. 2008. Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection. Clin. Vaccine Immunol. 15:522-533.
17. Geluk, A., J. S. Spencer, K. Bobosha, M. C. Pessolani, G. M. Pereira, S. Banu, N. Honore, S. T. Reece, M. Macdonald, B. R. Sapkota, C. Ranjit, K. L. Franken, M. Zewdie, A. Aseffa, R. Hussain, M. M. Stefani, S. N. Cho, L. Oskam, P. J. Brennan, and H. M. Dockrell. 2009. From genome-based in silico predictions to ex vivo verification of leprosy diagnosis. Clin. Vaccine Immunol. 16:352-359.
18. Hanekom, W. A., J. Hughes, M. Mavinkurve, M. Mendillo, M. Watkins, H. Gamieldien, S. J. Gelderbloem, M. Sidibana, N. Mansoor, V. Davids, R. A. Murray, A. Hawkridge, P. A. Haslett, S. Ress, G. D. Hussey, and G. Kaplan. 2004. Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies. J. Immunol. Methods 291:185-195.
19. Hiemstra, H. S., G. Duinkerken, W. E. Benckhuijsen, R. Amons, R. R. de Vries, B. O. Roep, and J. W. Drijfhout. 1997. The identification of CD4 T cell epitopes with dedicated synthetic peptide libraries. Proc. Natl. Acad. Sci. U. S. A. 94:10313-10318.
20. Hoeve, M. A., N. D. Savage, T. de Boer, D. M. Langenberg, R. de Waal-Malefyt, T. H. Ottenhoff, and F. A. Verreck. 2006. Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur. J. Immunol. 36:661-670.
21. Kalinski, P., C. M. Hilkens, A. Snijders, F. G. Snijdewint, and M. L. Kapsenberg. 1997. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J. Immunol. 159:28-35.
22. Lopez Roa, R. I., V. C. Guerrero, N. A. Alvarado, B. M. Montoya, N. C. Garcia, and M. M. Fafutis. 2008. Recovery of IFN-gamma levels in PBMCs from lepromatous leprosy patients through the synergistic actions of the cytokines IL-12 and IL-18. Int. Immunopharmacol. 8:1715-1720.
23. Oskam, L., E. Slim, and S. Buhrer-Sekula. 2003. Serology: recent developments, strengths, limitations and prospects: a state of the art overview. Lepr. Rev. 74:196-205.
24. Powell, M. F., H. Grey, F. Gaeta, A. Sette, and S. Colon. 1992. Peptide stability in drug development: a comparison of peptide reactivity in different biological media. J. Pharm. Sci. 81:731-735.
25. Ridley, D. S., and W. H. Jopling. 1966. Classification of leprosy according to immunity. A five-group system. Int. J. Lepr. Other Mycobact. Dis. 34:255-273.
26. Ruhwald, M., M. Bjerregaard-Andersen, P. Rabna, K. Kofoed, J. Eugen-Olsen, and P. Ravn. 2007. CXCL10/IP-10 release is induced by incubation of whole blood from tuberculosis patients with ESAT-6, CFP10 and TB7.7. Microbes Infect. 9:806-812.
27. Ruhwald, M., T. Bodmer, C. Maier, M. Jepsen, M. B. Haaland, J. Eugen- Olsen, and P. Ravn. 2008. Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis. Eur. Respir. J. 32:1607-1615.
28. Setia, M. S., C. Steinmaus, C. S. Ho, and G. W. Rutherford. 2006. The role of BCG in prevention of leprosy: a meta-analysis. Lancet Infect. Dis. 6:162-170.
29. Spencer, J. S., H. M. Dockrell, H. J. Kim, M. A. Marques, D. L. Williams, M. V. Martins, M. L. Martins, M. C. Lima, E. N. Sarno, G. M. Pereira, H. Matos, L. S. Fonseca, E. P. Sampaio, T. H. Ottenhoff, A. Geluk, S. N. Cho, N. G. Stoker, S. T. Cole, P. J. Brennan, and M. C. Pessolani. 2005. Identification of specific proteins and peptides in mycobacterium leprae suitable for the selective diagnosis of leprosy. J. Immunol. 175:7930-7938.
30. Stefani, M. M., J. G. Guerra, A. L. Sousa, M. B. Costa, M. L. Oliveira, C. T. Martelli, and D. M. Scollard. 2009. Potential plasma markers of type 1 and type 2 leprosy reactions: a preliminary report. BMC Infect. Dis. 9:75.
31. Tan, A. M. C., R. Jordens, A. Geluk, B. O. Roep, T. Ottenhoff, J. W. Drijfhout, and F. Koning. 1998. Strongly increased efficiency of altered peptide ligands by mannosylation. Int. Immunol. 10:1299-1304.
32. van de Vosse, E., G. Lichtenauer-Kaligis, J. T. van Dissel, and T. H. Ottenhoff. 2003. Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor structure and function. Immunogenetics 54:817-829.
33. Weekly Epidemiological Record. 2008. Global leprosy situation, beginning of 2008. Wkly. Epidemiol. Rec. 83:293-300.
34. Weir, R. E., C. R. Butlin, K. D. Neupane, S. S. Failbus, and H. M. Dockrell. 1998. Use of a whole blood assay to monitor the immune response to mycobacterial antigens in leprosy patients: a predictor for type 1 reaction onset? Lepr. Rev. 69:279-293.
35. Weir, R. E., A. R. Morgan, W. J. Britton, C. R. Butlin, and H. M. Dockrell. 1994. Development of a whole blood assay to measure T cell responses to leprosy: a new tool for immuno-epidemiological field studies of leprosy immunity. J. Immunol. Methods 176:93-101.