IL-2 and IL-12 Act in Synergy to Overcome Antigen-Specific T Cell Unresponsiveness in Mycobacterial Disease

Journal of Immunology

Volumn 159, Issue 2, 1997, Pages 786-793

  De Jong, Rolien ^a   Janson, Anneke A M ^a   Faber, William R ^b   Naafs, Ben ^a   Ottenhoff, Tom H M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 2; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; CELL CULTURE; CELL DIVISION; CELLULAR IMMUNITY; DRUG EFFECT; DRUG POTENTIATION; HUMAN; IMMUNOLOGY; LEPROSY; LYMPHOCYTE ACTIVATION; MOUSE; MYCOBACTERIUM LEPRAE; T LYMPHOCYTE;

ANIMALS; CELL DIVISION; CELLS, CULTURED; DRUG SYNERGISM; HUMANS; IMMUNITY, CELLULAR; INTERLEUKIN-12; INTERLEUKIN-2; LEPROSY; LYMPHOCYTE ACTIVATION; MICE; MYCOBACTERIUM LEPRAE; RECOMBINANT PROTEINS; T-LYMPHOCYTES;

EID: 0031570896     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
2. Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008.
3. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
4. Castro, A. G., R. A. Silva, and R. Appelberg. 1995. Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice. J. Immunol. 155:2013.
5. Appelberg, R., A. G. Castro, J. Pedrosa, R. A. Silva, I. M. Orme, and P. Minoprio. 1994. Role of IFN-γ and TNF-α during T-cell-independent and -dependent phases of Mycobacterium avium infection. Inject. Immun. 62:3962.
6. Cooper, A. M., D. K. Dalton, T. A. Stewart, J. P. Griffin, D. G. Russell, and I. M. Orme. 1993. Disseminated tuberculosis in IFN-γ gene-disrupted mice. J. Exp. Med. 178:2243.
7. Flynn, J. L., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for IFN-γ in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249.
8. Flynn, J. L., M. M. Goldstein, K. J. Triebold, J. Sypek, S. Wolf, and B. R. Bloom. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J. Immunol. 155:2515.
9. Cooper, A. M., A. D. Roberts, E. R. Rhoades, J. E. Callahan, D. M. Getzy, and I. M. Orme. 1995. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology 84:423.
10. Frucht, D. M., and S. M. Holland 1996. Defective monocyle costimulalion for IFN-γ production in familial disseminated Mycobacterium avium complex infection. J. Immunol. 157:411.
11. Newport, M. J., C. M. Huxley, S. Huston, C. M. Hawrylowicz, B. A. Oostra, R. Williamson, and M. Levin. 1996. A mutation in the IFN-γ receptor gene and susceptibility to mycobacterial infection. N. Engl. J. Med. 335:1941.
12. + T cell counts have impaired Th1 responses. J. Immunol. 158:492.
13. Chehimi, J., S. E. Starr, I. Frank, A. D'Andrea, X. Ma, R. R. MacGregor, J. Sennelier, and G. Trichieri. 1994. Impaired IL-12 production in human immunodeficiency virus-infected patients. J. Exp. Med. 179:1361.
14. Clerici, M., D. R. Lucey, J. A. Berzofsky, L. A. Pinto, T. A. Wynn, S. P. Blatt, M. J. Dolan, C. W. Hendrix, S. F. Wolf, and G. M. Shearer. 1993. Restoration of HIV-specific cell-mediated immune responses by IL-12 in vitro. Science 262: 1721.
15. Yamamura, M., K. Uyemura, R. J. Deans, K. Weinberg, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1991. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254:277.
16. Salgame, P., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Nature 254:279.
17. Ottenhoff, T. H. M., D. G. Elferink, P. R. Klatser, and R. R. P. de Vries. 1986. Cloned suppressor T cells from a lepromatous leprosy patient suppress Mycobacterium leprae reactive helper T cells. Nature 322:462.
18. Modlin, R. L., H. Kato, V. Mehra, E. E. Nelson, F. Xue-dong, T. H. Rea, P. K. Pattengale, and B. R. Bloom. 1986. Genetically restricted suppressor T-cell clones derived from lepromatous leprosy patients. Nature 322:459.
19. Sieling, P. A., X. Wang, M. K. Gately, J. L. Oliveros, T. McHugh, P. F. Barnes, S. F. Wolf, L. Golkar, M. Yamamura, Y. Yogi, K. Uyemura, T. H. Rea, and R. L. Modlin. 1994. IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J. Immunol. 153:3639.
20. Ottenhoff, T. H. M., D. G. Elferink, and R. R. P. de Vries. 1984. Unresponsiveness to Mycobacterium leprae in lepromatous leprosy in vitro: reversible or not? Int. J. Lepr. 52:419.
21. Sieling, P. A., J. S. Abrams, M. Yamamura, P. Salgame, B. R. Bloom, T. H. Rea, and R. L. Modlin. 1993. Immunosuppressive roles for IL-10 and IL-4 in human infection. J. Immunol. 150:5501.
22. Mutis, T., E. M. Kraakman, Y. E. Cornelisse, J. B. A. G. Haanen, H. Spits, R. R. P. de Vries, and T. H. M. Ottenhoff. 1993. Analysis of cytokine production by Mycobacterium-reactive T cells. J. Immunol. 150:4641.
23. Haregewoin, A., T. Godal, A. S. Mustafa, A. Belehu, and T. Yemaneberhan. 1983. T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy. Nature 303:342.
24. Kaplan, G., D. E. Weinstein, R. M. Steinman, W. R. Levis, U. Elvers, M. E. Patarroyo, and Z. A. Cohn. 1985. An analysis of in vitro T cell responsiveness in lepromatous leprosy. J. Exp. Med. 162:917.
25. Mohagheghpour, N., R. H. Gelber, J. W. Larrick, D. T. Sasaki, P. J. Brennan, and E. G. Engleman. 1985. Defective cell-mediated immunity m leprosy: failure of T cells from lepromatous leprosy patients to respond to Mycobacterium leprae is associated with defective expression of interleukin 2 receptors and is not reconstituted by interleukin 2. J. Immunol. 135:1443.
26. Ottenhoff, T. H. M., A. Wondimu, and N. N. B. Reddy. 1990. A comparative study on the effects of rIL-4, rIL-2, rIFN-γ, and rTNFα on specific T-cell non-responsiveness to mycobacterial antigens in lepromatous leprosy patients in vitro. Scand. J. Immunol. 31:553.
27. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Konayashi, D. Young, E. Nickbarg, R. Chizzonite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
28. 2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:775.
29. Van der Meide, P. H., M. Dubbeld, and H. Schellekens. 1985. Monoclonal antibodies to human immune interferon and their use in a sensitive solid-phase ELISA. J. Immunol. Methods 79:293.
30. Goodwin, J. S., R. DeHoratius, H. Israel, G. T. Peake, and R. P. Messner. 1979. Suppressor cell function in sarcoidosis. Ann. Intern. Med. 90:169.
31. Goodwin, J. S., R. P. Messner, A. D. Bankhurst, G. T. Peake, J. H. Saiki, and R. C. Williams. 1977. Prostaglandin-producing suppressor cells in Hodgkin's disease. N. Engl. J. Med. 297:963.
32. + T cells. J. Immunol. 156:1722.
33. Bloom, B. R., and V. Mehra. 1984. Immunological unresponsiveness in leprosy. Immunol. Rev. 80:5.
34. Kaplan, G., R. Kiessling, S. Teklemariam, G. Hancock, G. Sheftel, C. K. Job, P. Converse, T. H. M. Ottenhoff, M. Becx-Bleumink, M. Dietz, and Z. A. Cohn. 1989. The reconstitution of cell-mediated immunity in the cutaneous lesions of lepromatous leprosy by recombinant interleukin 2. J. Exp. Med. 169:893.
35. Snijders, A., C. M. U. Hilkens, T. C. T. M. van der Pouw-Kraan, M. Engel, L. A. Aarden, and M. L. Kapsenberg. 1996. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J. Immunol. 156:1207.
36. Sieling P. A., L. Sakimura, K. Uyemura, M. Yamamura, J. Oliveros, B. J. Nickoloff, T. H. Rea, and R. L. Modlin. 1995. IL-7 in the cell-mediated immune response to a human pathogen. J. Immunol. 154:2775.
37. Pernis, A., S. Gupta, J. Gollob, H. Garfein, R. L. Coffman, C. Schindler, and P. Rothman. 1995. Lack of IFN-γ receptor β chain and the prevention of IFN-γ signaling in Th1 cells. Science 269:245.
38. Germann, T., M. K. Gately, D. S. Schoenhaut, M. Lohoff, F. Mattner, S. Fischer, S. Jin, E. Schmitt, and E. Rude. 1993. Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur. J. Immunol. 23:1762.
39. Szabo, S. J., N. G. Jacobson, A. S. Dighe, U. Gubler, and K. M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signalling. Immunity 2:665.
40. Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea, and J. A. Johnston. 1995. Interleukin 12 induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399.
41. Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (stat) 3 and stat4. J. Exp. Med. 181:1755.
42. Johnston, J. A., C. M. Bacon, D. S. Finbloom, R. C. Rees, D. Kaplan, K. Shibuya, J. R. Ortaldo, S. Gupta, Y. Q. Chen, J. D. Giri, and J. J. O'Shea. 1995. Tyrosine phosphorylation and activation of stat5, stat3, and Janus kinases by interleukins 2 and 15. Proc. Natl. Acad. Sci. USA 92:8705.