Development of antiproliferative phenylmaleimides that activate the unfolded protein response

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4535-4541

  Muus, Ulrike ^a   Hose, Curtis ^b   Yao, Wei ^a   Kosakowska Cholody, Teresa ^a   Farnsworth, David ^a   Dyba, Marzena ^b   Lountos, George T ^a   Waugh, David S ^a   Monks, Anne ^b   Burke Jr , Terrence R ^a   Michejda, Christopher J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

Antiproliferative; Cdc25; Protein alkylation; Unfolded protein response

Indexed keywords

CHAPERONE; CYSTEINE; MALEIMIDE DERIVATIVE; PHENYLMALEIMIDE DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG; ALKYLATING AGENT;

ALKYLATION; APOPTOSIS; ARTICLE; CATALYSIS; CELL ASSAY; CELL CULTURE; CELL CYCLE; CELL DAMAGE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IC 50; MOLECULE; PROTEIN FOLDING; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, ALKYLATING; CDC25 PHOSPHATASES; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; HUMANS; MALEIMIDES; UNFOLDED PROTEIN RESPONSE;

EID: 77953140151     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.057     Document Type: Article

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