Impact of arginase II on CBF in experimental cortical impact injury in mice using MRI

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 6, 2010, Pages 1105-1109

  Bitner, Brittany R ^a   Brink, Danielle C ^a   Mathew, Leela C ^a   Pautler, Robia G ^a   Robertson, Claudia S ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Arginase II; CBF; MRI; NO; TBI

Indexed keywords

ARGINASE; ARGINASE II; ARGININE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; ENZYME DEFICIENCY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SPIN LABELING; TRAUMATIC BRAIN INJURY;

ANIMALS; ARGINASE; BLOOD FLOW VELOCITY; BRAIN INJURIES; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MICE; MICE, KNOCKOUT;

EID: 77953131909     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.47     Document Type: Article

References (13)

1. Cherian L, Hlatky R, Robertson CS (2004) Nitric oxide in traumatic brain injury. Brain Pathol 14:195-201
2. Cherian L, Robertson CS (2003) L-arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in rats. J Neurotrauma 20:77-85
3. Cherian L, Sheiko T, Bryan R, Craigen W, Goodman C, Robertson CS (2009) Inhibition of arginase with N-hydroxy-nor-L-arginine (NOHA) reduces histological damage after cortical impact injury. J Neurotrauma 26:A-96
4. DeWitt DS, Smith TG, Deyo DJ, Miller KR, Uchida T, Prough DS (1997) L-arginine and superoxide dismutase prevent or reverse cerebral hypoperfusion after fluid-percussion traumatic brain injury. J Neurotrauma 14:223-233
5. Durante W, Johnson FK, Johnson RA (2007) Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin Exp Pharmacol Physiol 34:906-911
6. Golding EM, Robertson CS, Bryan RM (1999) The consequences of traumatic brain injury on cerebral blood flow and autoregulation: a review. Clin Exp Hypertens 21:299-332
7. Herscovitch P, Raichle ME (1985) What is the correct value for the brain-blood partition coefficient for water? J Cereb Blood Flow Metab 5:65-69
8. Hlatky R, Lui H, Cherian L, Goodman JC, O'Brien WE, Contant CF, Robertson CS (2003) The role of endothelial nitric oxide synthase in the cerebral hemodynamics after controlled cortical impact injury in mice. J Neurotrauma 20:995-1006
9. Huynh NN, Andrews KL, Head GA, Khong SML, Mayorov DN, Murphy AJ, Lambert G, Kiriazis H, Xu Q, Du X, Chin-Dusting JPF (2009) Arginase II knockout mouse displays a hypertensive phenotype despite a decreased vasoconstrictory profile. Hypertension 54:294-301
10. Lim HK, Lim HK, Ryoo S, Benjo A, Shuleri K, Miriel V, Baraban E, Camara A, Soucy K, Nyhan D, Shoukas A, Berkowitz DE (2007) Mitochondrial arginase II constrains endothelial NOS-3 activity. Am J Physiol Heart Circ Physiol 293:H3317-24
11. Liu H, Goodman JC, Robertson CS (2002) The effects of L-arginine on cerebral hemodynamics after controlled cortical impact injury in the mouse. J Neurotrauma 19:327-334
12. Shi O, Morris SM, Zoghbi H, Porter CW, OBrien WE (2001) Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene. Mol Cell Biol 21:811-813
13. Williams DS, Detre JA, Leigh JS, Koretsky AP (1992) Magnetic resonance imaging of perfusion using spin inversion of arterial water. Proc Natl Acad Sci USA 89:212-216