Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 12, 2006, Pages 3156-3161

  Penning, Thomas D ^a   Khilevich, Albert ^a   Chen, Barbara B ^a   Russell, Mark A ^a   Boys, Mark L ^a   Wang, Yaping ^a   Duffin, Tiffany ^a   Engleman, V Wayne ^a   Finn, Mary Beth ^a   Freeman, Sandra K ^a   Hanneke, Melanie L ^a   Keene, Jeffery L ^a   Klover, Jon A ^a   Nickols, G Allen ^a   Nickols, Maureen A ^a   Rader, Randall K ^a   Settle, Steven L ^a   Shannon, Kristen E ^a   Steininger, Christina N ^a   Westlin, Marisa M ^a   Westlin, William F ^a   more..

^a PFIZER INC   (United States)

Author keywords

v 3; Integrin antagonist; RGD peptidomimetic

Indexed keywords

ISOXAZOLE DERIVATIVE; NANOPARTICLE; PYRAZOLE DERIVATIVE; PYRAZOLE; VITRONECTIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RECEPTOR BINDING; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; MOUSE; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CELL LINE; HUMANS; INTEGRIN ALPHAVBETA3; ISOXAZOLES; MICE; MOLECULAR STRUCTURE; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747116507     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.045     Document Type: Article

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