Solvent injection-lyophilization of tert-butyl alcohol/water cosolvent systems for the preparation of drug-loaded solid lipid nanoparticles

Colloids and Surfaces B: Biointerfaces

Volumn 79, Issue 1, 2010, Pages 254-261

  Wang, Ting ^a   Wang, Ning ^a   Zhang, Yingying ^a   Shen, Wancui ^a   Gao, Xingmei ^a   Li, Tiefu ^b  

^a JINING MEDICAL UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cosolvent; Drug carrier; Encapsulation efficiency; Lipid; Solubilization

Indexed keywords

5-FLUOROURACIL; AQUEOUS DISPERSIONS; AQUEOUS SOLUTIONS; CINNARIZINE; COSOLVENTS; DRUG CARRIER; DRY PRODUCTS; EFFICIENT METHOD; ENCAPSULATION EFFICIENCY; HIGH TEMPERATURE; LIPID MASS; LIPOPHILIC DRUGS; LYOPROTECTANTS; RECRYSTALLIZATIONS; REVERSE MICELLES; SMALL ANGLE X-RAY SCATTERING; SOLID LIPID NANOPARTICLES; SOLVENT INJECTION; TERT-BUTYL ALCOHOLS;

ALCOHOLS; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSIONS; DISSOLUTION; LIPIDS; NANOPARTICLES; OPTICAL DATA STORAGE; ORGANIC SOLVENTS; SCATTERING; SOLUBILITY;

ENCAPSULATION;

CINNARIZINE; FLUOROURACIL; SOLID LIPID NANOPARTICLE; TERT BUTYL ALCOHOL;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DISPERSION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; EVAPORATION; FREEZE DRYING; HIGH TEMPERATURE; HYDROPHILICITY; INTERMETHOD COMPARISON; LIPOPHILICITY; MICELLIZATION; NANOENCAPSULATION; PARTICLE SIZE; PRIORITY JOURNAL; REVERSE MICELLE;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; LIPIDS; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS; SCATTERING, SMALL ANGLE; SOLVENTS; TEMPERATURE; TERT-BUTYL ALCOHOL; WATER; X-RAY DIFFRACTION;

EID: 77953126125     PISSN: 09277765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2010.04.005     Document Type: Article

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