Disease-causing missense mutations in actin binding domain 1 of dystrophin induce thermodynamic instability and protein aggregation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 21, 2010, Pages 9632-9637

  Henderson, Davin M ^a   Lee, Ann ^a   Ervasti, James M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Calponin homology domain; Muscular dystrophy; Thermal stability

Indexed keywords

COMPLEMENTARY DNA; DYSTROPHIN;

ACTIN BINDING PROTEIN DOMAIN 1; ARTICLE; BINDING AFFINITY; CARDIOMYOPATHY; CIRCULAR DICHROISM; CONTROLLED STUDY; DISEASE COURSE; DUCHENNE MUSCULAR DYSTROPHY; LIGAND BINDING; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STABILITY; THERMOSTABILITY;

ACTINS; ANIMALS; CIRCULAR DICHROISM; DYSTROPHIN; HUMANS; MICE; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STABILITY; THERMODYNAMICS;

EID: 77953108170     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1001517107     Document Type: Article

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