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Volumn 49, Issue 22, 2010, Pages 4568-4570
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A distal point mutation in the streptavidin?biotin complex preserves structure but diminishes binding affinity: Experimental evidence of electronic polarization effects?
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Author keywords
[No Author keywords available]
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Indexed keywords
BINDING AFFINITIES;
BIOTIN BINDING;
BIOTIN COMPLEXES;
COMPLEX STRUCTURE;
COMPUTATIONAL STUDIES;
DISTAL POINTS;
ELECTRONIC POLARIZATION EFFECT;
EXPERIMENTAL EVIDENCE;
HYDROGEN BONDING NETWORK;
LIGAND INTERACTIONS;
MOLECULAR DYNAMICS SIMULATIONS;
SIDE CHAINS;
SMALL CAVITIES;
STREPTAVIDIN;
WATER MOLECULE;
BINDING ENERGY;
COENZYMES;
MOLECULAR DYNAMICS;
MOLECULES;
PHASE EQUILIBRIA;
POLARIZATION;
PROTEINS;
HYDROGEN BONDS;
BIOTIN;
STREPTAVIDIN;
ARTICLE;
BINDING AFFINITY;
COMPLEX FORMATION;
HYDROGEN BOND;
MOLECULAR DYNAMICS;
MOLECULAR INTERACTION;
POINT MUTATION;
POLARIZATION;
PRIORITY JOURNAL;
PROTEIN STRUCTURE;
SIMULATION;
BINDING SITES;
BIOTIN;
ELECTRONS;
HYDROGEN BONDING;
LEUCINE;
LIGANDS;
MOLECULAR DYNAMICS SIMULATION;
PHENYLALANINE;
POINT MUTATION;
PROTEIN BINDING;
PROTEIN STABILITY;
STREPTAVIDIN;
THERMODYNAMICS;
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EID: 77953103390
PISSN: 00062960
EISSN: 15204995
Source Type: Journal
DOI: 10.1021/bi1005392 Document Type: Article |
Times cited : (11)
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References (14)
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