Estrogen receptor ESR1 is indispensable for the induction of persistent vaginal change by neonatal 5alpha-dihydrotestosterone exposure in mice

Biology of Reproduction

Volumn 82, Issue 3, 2010, Pages 497-503

  Miyagawa, Shinichi ^a,b   Katsu, Yoshinao ^a,b   Ohta, Yasuhiko ^c   Sudo, Tamotsu ^d   Lubahn, Dennis B ^e   Iguchi, Taisen ^a,b,c  

^a OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d HYOGO CANCER CENTER   (Japan)

^e UNIVERSITY OF MISSOURI   (United States)

Author keywords

5 dihydrotestosterone (DHT); Developmental effect; Estradiol; Estrogen receptor 1 ( ) (ESR1); External genitalia; Female reproductive tract; Mouse; Penis; Testosterone; Vagina

Indexed keywords

5ALPHA ANDROSTAN 3 ONE; ANDROGEN RECEPTOR; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ANDROSTANOLONE;

ANDROGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEMALE; GENOTYPE; HISTOLOGY; HYPOSPADIAS; MOUSE; NEWBORN; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; VAGINA EPITHELIUM; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL STRAIN HEPG2; CHEMICALLY INDUCED DISORDER; CONGENITAL MALFORMATION; DRUG EFFECT; FEMALE GENITAL SYSTEM; GENETICS; GROWTH, DEVELOPMENT AND AGING; GYNECOLOGIC DISEASE; HUMAN; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; TIME; UROGENITAL TRACT MALFORMATION; VAGINA;

ANIMALIA; MUS;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DIHYDROTESTOSTERONE; ESTROGEN RECEPTOR ALPHA; FEMALE; GENITAL DISEASES, FEMALE; GENITALIA, FEMALE; HEP G2 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ANDROGEN; TIME FACTORS; UROGENITAL ABNORMALITIES; VAGINA;

EID: 77953094214     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.109.081315     Document Type: Article

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