메뉴 건너뛰기




Volumn 150, Issue 7, 2009, Pages 3274-3282

Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE;

EID: 67649642147     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1750     Document Type: Article
Times cited : (89)

References (64)
  • 1
    • 0023910355 scopus 로고
    • Cloning of human androgen receptor complementary DNA and localization to the X chromomose
    • Lubahn DB, Joseph DR, Sullivan PM, Willard HF, French FS, Wilson EM 1988 Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science 240:327-330 (Pubitemid 18116696)
    • (1988) Science , vol.240 , Issue.4850 , pp. 327-330
    • Lubahn, D.B.1    Joseph, D.R.2    Sullivan, P.M.3    Willard, H.F.4    French, F.S.5    Wilson, E.M.6
  • 2
    • 0028333722 scopus 로고
    • Follicular oestrogen synthesis: The 'two-cell, two-gonadotrophin' model revisited
    • Hillier SG, Whitelaw PF, Smyth CD 1994 Follicular oestrogen synthesis: the 'two-cell, two-gonadotrophin' model revisited. Mol Cell Endocrinol 100:51-54
    • (1994) Mol Cell Endocrinol , vol.100 , pp. 51-54
    • Hillier, S.G.1    Whitelaw, P.F.2    Smyth, C.D.3
  • 3
    • 34547093857 scopus 로고    scopus 로고
    • Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility
    • Walters KA, Allan CM, Jimenez M, Lim PR, Davey RA, Zajac JD, Illingworth P, Handelsman DJ 2007 Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility. Endocrinology 148:3674-3684
    • (2007) Endocrinology , vol.148 , pp. 3674-3684
    • Walters, K.A.1    Allan, C.M.2    Jimenez, M.3    Lim, P.R.4    Davey, R.A.5    Zajac, J.D.6    Illingworth, P.7    Handelsman, D.J.8
  • 8
    • 0021954460 scopus 로고
    • Distribution of specific androgen binding sites within the ovine ovarian follicle
    • DOI 10.1016/0303-7207(85)90069-3
    • Campo SM, Carson RS, Findlay JK 1985 Distribution of specific androgen binding sites within the ovine ovarian follicle. Mol Cell Endocrinol 39:255-265 (Pubitemid 15134950)
    • (1985) Molecular and Cellular Endocrinology , vol.39 , Issue.3 , pp. 255-265
    • Campo, S.M.1    Carson, R.S.2    Findlay, J.K.3
  • 10
    • 0026587410 scopus 로고
    • Immunohistochemical localization of androgen receptor in the human ovary throughout the menstrual cycle in relation to oestrogen and progesterone receptor expression
    • Horie K, Takakura K, Fujiwara H, Suginami H, Liao S, Mori T 1992 Immunohistochemical localization of androgen receptor in the human ovary throughout the menstrual cycle in relation to oestrogen and progesterone receptor expression. Hum Reprod 7:184-190
    • (1992) Hum Reprod , vol.7 , pp. 184-190
    • Horie, K.1    Takakura, K.2    Fujiwara, H.3    Suginami, H.4    Liao, S.5    Mori, T.6
  • 14
    • 0032764132 scopus 로고    scopus 로고
    • Androgens promote oocyte insulin-like growth factor I expression and initiation of follicle development in the primate ovary
    • DOI 10.1095/biolreprod61.2.353
    • Vendola K, Zhou J, Wang J, Famuyiwa OA, Bievre M, Bondy CA 1999 Androgens promote oocyte insulin-like growth factor I expression and initiation of follicle development in the primate ovary. Biol Reprod 61:353-357 (Pubitemid 29344748)
    • (1999) Biology of Reproduction , vol.61 , Issue.2 , pp. 353-357
    • Vendola, K.1    Zhou, J.2    Wang, J.3    Famuyiwa, O.A.4    Bievre, M.5    Bondy, C.A.6
  • 15
    • 0034751421 scopus 로고    scopus 로고
    • Effect of adrenal and ovarian androgens on type 4 follicles unresponsive to FSH in immature mice
    • DOI 10.1210/en.142.11.4930
    • Wang H, Andoh K, Hagiwara H, Xiaowei L, Kikuchi N, Abe Y, Yamada K, Fatima R, Mizunuma H 2001 Effect of adrenal and ovarian androgens on type 4 follicles unresponsive to FSH in immature mice. Endocrinology 142:4930-4936 (Pubitemid 33022369)
    • (2001) Endocrinology , vol.142 , Issue.11 , pp. 4930-4936
    • Wang, H.1    Andoh, K.2    Hagiwara, H.3    Xiaowei, L.4    Kikuchi, N.5    Abe, Y.6    Yamada, K.7    Fatima, R.8    Mizunuma, H.9
  • 16
    • 0031765501 scopus 로고    scopus 로고
    • Androgen receptor in mouse brain: Sex differences and similarities in autoregulation
    • Lu SF, McKenna SE, Cologer-Clifford A, Nau EA, Simon NG 1998 Androgen receptor in mouse brain: sex differences and similarities in autoregulation. Endocrinology 139:1594-1601 (Pubitemid 28513814)
    • (1998) Endocrinology , vol.139 , Issue.4 , pp. 1594-1601
    • Lu, S.-F.1    Mckenna, S.E.2    Cologer-Clifford, A.3    Nau, E.A.4    Simon, N.G.5
  • 17
    • 0025797245 scopus 로고
    • Sex differences in androgen receptors and aromatase activity in microdissected regions of the rat brain
    • Roselli CE 1991 Sex differences in androgen receptors and aromatase activity in microdissected regions of the rat brain. Endocrinology 128:1310-1316
    • (1991) Endocrinology , vol.128 , pp. 1310-1316
    • Roselli, C.E.1
  • 18
    • 13444251303 scopus 로고    scopus 로고
    • Sex differences in the distribution and abundance of androgen receptor mRNA-containing cells in the preoptic area and hypothalamus of the ram and ewe
    • DOI 10.1111/j.1365-2826.2005.01261.x
    • Scott CJ, Clarke IJ, Rao A, Tilbrook AJ 2004 Sex differences in the distribution and abundance of androgen receptor mRNA-containing cells in the preoptic area and hypothalamus of the ram and ewe. J Neuroendocrinol 16:956-963 (Pubitemid 40214440)
    • (2004) Journal of Neuroendocrinology , vol.16 , Issue.12 , pp. 956-963
    • Scott, C.J.1    Clarke, I.J.2    Rao, A.3    Tilbrook, A.J.4
  • 19
    • 0034715315 scopus 로고    scopus 로고
    • Sex differences in the distribution of androgen receptors in the human hypothalamus
    • DOI 10.1002/1096-9861(20000925)425:3<422::AID-CNE7>3.0.CO;2-H
    • Fernández-Guasti A, Kruijver FP, Fodor M, Swaab DF 2000 Sex differences in the distribution of androgen receptors in the human hypothalamus. J Comp Neurol 425:422-435 (Pubitemid 30659207)
    • (2000) Journal of Comparative Neurology , vol.425 , Issue.3 , pp. 422-435
    • Fernandez-Guasti, A.1    Kruijver, F.P.M.2    Fodor, M.3    Swaab, D.F.4
  • 20
    • 0017727247 scopus 로고
    • 3H]-dihydrotestosterone administration
    • Sar M, Stumpf WE 1977 Distribution of androgen target cells in rat forebrain and pituitary after [3H]-dihydrotestosterone administration. J Steroid Biochem 8:1131-1135 (Pubitemid 8220832)
    • (1977) Journal of Steroid Biochemistry , vol.8 , Issue.11 , pp. 1131-1135
    • Sar, M.1    Stumpf, W.E.2
  • 22
    • 3042606867 scopus 로고    scopus 로고
    • Androgen receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain
    • DOI 10.1016/j.neurobiolaging.2003.10.011, PII S0197458003002276
    • Kumar RC, Thakur MK 2004 Androgen receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain. Neurobiol Aging 25:925-933 (Pubitemid 38813172)
    • (2004) Neurobiology of Aging , vol.25 , Issue.7 , pp. 925-933
    • Kumar, R.C.1    Thakur, M.K.2
  • 23
    • 0842303575 scopus 로고    scopus 로고
    • Localization and estrogenic regulation of androgen receptor mRNA expression in the mouse uterus and vagina
    • DOI 10.1677/joe.0.1800077
    • Pelletier G, Luu-The V, Li S, Labrie F 2004 Localization and estrogenic regulation of androgen receptor mRNA expression in the mouse uterus and vagina. J Endocrinol 180:77-85 (Pubitemid 38180759)
    • (2004) Journal of Endocrinology , vol.180 , Issue.1 , pp. 77-85
    • Pelletier, G.1    Luu-The, V.2    Li, S.3    Labrie, F.4
  • 25
    • 0033819596 scopus 로고    scopus 로고
    • Localization of androgen and estrogen receptors in rat and primate tissues
    • Pelletier G 2000 Localization of androgen and estrogen receptors in rat and primate tissues. Histol Histopathol 15:1261-1270 (Pubitemid 30763071)
    • (2000) Histology and Histopathology , vol.15 , Issue.4 , pp. 1261-1270
    • Pelletier, G.1
  • 26
    • 0033081815 scopus 로고    scopus 로고
    • Localization and sex steroid regulation of androgen receptor gene expression in rhesus monkey uterus
    • DOI 10.1016/S0029-7844(98)00384-6, PII S0029784498003846
    • Adesanya-Famuyiwa OO, Zhou J, Wu G, Bondy C 1999 Localization and sex steroid regulation of androgen receptor gene expression in rhesus monkey uterus. Obstet Gynecol 93:265-270 (Pubitemid 29068104)
    • (1999) Obstetrics and Gynecology , vol.93 , Issue.2 , pp. 265-270
    • Adesanya-Famuyiwa, O.O.1    Zhou, J.2    Wu, G.3    Bondy, C.4
  • 27
    • 0027418018 scopus 로고
    • Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues
    • Kimura N, Mizokami A, Oonuma T, Sasano H, Nagura H 1993 Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues. J Histochem Cytochem 41:671-678 (Pubitemid 23118737)
    • (1993) Journal of Histochemistry and Cytochemistry , vol.41 , Issue.5 , pp. 671-678
    • Kimura, N.1    Mizokami, A.2    Oonuma, T.3    Sasano, H.4    Nagura, H.5
  • 28
    • 0033804845 scopus 로고    scopus 로고
    • Do androgens have a direct effect on endometrial function? An in vitro study
    • DOI 10.1016/S0015-0282(00)00711-1, PII S0015028200007111
    • Tuckerman EM, Okon MA, Li T, Laird SM 2000 Do androgens have a direct effect on endometrial function? An in vitro study. Fertil Steril 74:771-779 (Pubitemid 30742715)
    • (2000) Fertility and Sterility , vol.74 , Issue.4 , pp. 771-779
    • Tuckerman, E.M.1    Okon, M.A.2    Li, T.-C.3    Laird, S.M.4
  • 29
    • 0017147968 scopus 로고
    • Uterotrophic effects of testosterone and 5′-dihydrotestosterone in intact and ovariectomized immature female rats
    • Armstrong DT, Moon YS, Leung PC 1976 Uterotrophic effects of testosterone and 5′-dihydrotestosterone in intact and ovariectomized immature female rats. Biol Reprod 15:107-114
    • (1976) Biol Reprod , vol.15 , pp. 107-114
    • Armstrong, D.T.1    Moon, Y.S.2    Leung, P.C.3
  • 31
    • 16644384625 scopus 로고    scopus 로고
    • Synergistic effects of androgen and estrogen on the mouse uterus and mammary gland
    • Zhang J, Sun Y, Liu Y, Sun Y, Liao DJ 2004 Synergistic effects of androgen and estrogen on the mouse uterus and mammary gland. Oncol Rep 12:709-716
    • (2004) Oncol Rep , vol.12 , pp. 709-716
    • Zhang, J.1    Sun, Y.2    Liu, Y.3    Sun, Y.4    Liao, D.J.5
  • 32
    • 0018509465 scopus 로고
    • Androgen-uterine interactions: An assessment of androgen interaction with the testosterone- And estrogen-receptor systems and stimulation of uterine growth and progesterone-receptor synthesis
    • Schmidt WN, Katzenellenbogen BS 1979 Androgen-uterine interactions: an assessment of androgen interaction with the testosterone- and estrogen-receptor systems and stimulation of uterine growth and progesterone-receptor synthesis. Mol Cell Endocrinol 15:91-108
    • (1979) Mol Cell Endocrinol , vol.15 , pp. 91-108
    • Schmidt, W.N.1    Katzenellenbogen, B.S.2
  • 33
    • 1942476848 scopus 로고    scopus 로고
    • Uterine Androgen Receptors: Roles in Estrogen-Mediated Gene Expression and DNA Synthesis
    • DOI 10.1095/biolreprod.103.024786
    • Kowalski AA, Vale-Cruz DS, Simmen FA, Simmen RC 2004 Uterine androgen receptors: roles in estrogen-mediated gene expression and DNA synthesis. Biol Reprod 70:1349-1357 (Pubitemid 38509682)
    • (2004) Biology of Reproduction , vol.70 , Issue.5 , pp. 1349-1357
    • Kowalski, A.A.1    Vale-Cruz, D.S.2    Simmen, F.A.3    Simmen, R.C.M.4
  • 34
    • 0029817750 scopus 로고    scopus 로고
    • Maintenance of decidual cell reaction by androgens in the mouse
    • Zhang X, Croy BA 1996 Maintenance of decidual cell reaction by androgens in the mouse. Biol Reprod 55:519-524 (Pubitemid 26295049)
    • (1996) Biology of Reproduction , vol.55 , Issue.3 , pp. 519-524
    • Zhang, X.1    Croy, B.A.2
  • 35
    • 52949083991 scopus 로고    scopus 로고
    • Effects of androgen on embryo implantation in the mouse delayed-implantation model
    • Diao HL, Su RW, Tan HN, Li SJ, Lei W, Deng WB, Yang ZM 2008 Effects of androgen on embryo implantation in the mouse delayed-implantation model. Fertil Steril 90(Suppl 4):1376-1383
    • (2008) Fertil Steril , vol.90 , Issue.SUPPL. 4 , pp. 1376-1383
    • Diao, H.L.1    Su, R.W.2    Tan, H.N.3    Li, S.J.4    Lei, W.5    Deng, W.B.6    Yang, Z.M.7
  • 36
    • 0033017958 scopus 로고    scopus 로고
    • Infertility in a line of mice with the high growth mutation is due to luteal insufficiency resulting from disruption at the hypothalamic-pituitary axis
    • DOI 10.1095/biolreprod61.1.283
    • Cargill SL, Medrano JF, Anderson GB 1999 Infertility in a line of mice with the high growth mutation is due to luteal insufficiency resulting from disruption at the hypothalamic-pituitary axis. Biol Reprod 61:283-287 (Pubitemid 29295996)
    • (1999) Biology of Reproduction , vol.61 , Issue.1 , pp. 283-287
    • Cargill, S.L.1    Medrano, J.F.2    Anderson, G.B.3
  • 37
    • 34250974627 scopus 로고    scopus 로고
    • Ferbemethode zum makroskopischen nachweis von implantationsstellen am uterus der ratte
    • Salewski E 2007 Ferbemethode zum makroskopischen nachweis von implantationsstellen am uterus der ratte. Arch Exp Pathol Pharmakol 247:367-372
    • (2007) Arch Exp Pathol Pharmakol , vol.247 , pp. 367-372
    • Salewski, E.1
  • 38
    • 0033305055 scopus 로고    scopus 로고
    • 2)-treated, progesterone receptor knockout (PRKO) mice
    • Chappell PE, Schneider JS, Kim P, Xu M, Lydon JP, O'Malley BW, Levine JE 1999 Absence of gonadotropin surges and gonadotropin-releasing hormone self-priming in ovariectomized (OVX), estrogen (E2)-treated, progesterone receptor knockout (PRKO) mice. Endocrinology 140:3653-3658 (Pubitemid 30645420)
    • (1999) Endocrinology , vol.140 , Issue.8 , pp. 3653-3658
    • Chappell, P.E.1    Schneider, J.S.2    Kim, P.3    Xu, M.4    Lydon, J.P.5    O'Malley, B.W.6    Levine, J.E.7
  • 40
    • 0036892154 scopus 로고    scopus 로고
    • Direct response of the murine prostate gland and seminal vesicles to estradiol
    • DOI 10.1210/en.2002-220493
    • Bianco JJ, Handelsman DJ, Pedersen JS, Risbridger GP 2002 Direct response of the murine prostate gland and seminal vesicles to estradiol. Endocrinology 143:4922-4933 (Pubitemid 35397632)
    • (2002) Endocrinology , vol.143 , Issue.12 , pp. 4922-4933
    • Bianco, J.J.1    Handelsman, D.J.2    Pedersen, J.S.3    Risbridger, G.P.4
  • 41
    • 32444451851 scopus 로고    scopus 로고
    • Advances in the management of endometriosis: An update for clinicians
    • DOI 10.1093/humupd/dmi049
    • Crosignani P, Olive D, Bergqvist A, Luciano A 2006 Advances in the management of endometriosis: an update for clinicians. Hum Reprod Update 12:179-189 (Pubitemid 43231450)
    • (2006) Human Reproduction Update , vol.12 , Issue.2 , pp. 179-189
    • Crosignani, P.1    Olive, D.2    Bergqvist, A.3    Luciano, A.4
  • 43
    • 0024203372 scopus 로고
    • Preliminary report on the use of danazol in the treatment of endometrial adenomatous hyperplasia
    • DOI 10.1002/1097-0142(19881215)62:12<2618::AID-CNCR2820621228>3.0. CO;2-I
    • Terakawa N, Inoue M, Shimizu I, Ikegami H, Mizutani T, Sakata M, Tanizawa O, Matsumoto K 1988 Preliminary report on the use of danazol in the treatment of endometrial adenomatous hyperplasia. Cancer 62:2618-2621 (Pubitemid 19006449)
    • (1988) Cancer , vol.62 , Issue.12 , pp. 2618-2621
    • Terakawa, N.1    Inoue, M.2    Shimizu, I.3    Ikegami, H.4    Mizutani, T.5    Sakata, M.6    Tanizawa, O.7    Matsumoto, K.8
  • 46
    • 34547581086 scopus 로고    scopus 로고
    • Testosterone inhibits matrix metalloproteinase-1 production in human endometrial stromal cells in vitro
    • DOI 10.1530/rep.1.01089
    • Ishikawa T, Harada T, Kubota T, Aso T 2007 Testosterone inhibits matrix metalloproteinase-1 production in human endometrial stromal cells in vitro. Reproduction 133:1233-1239 (Pubitemid 47194252)
    • (2007) Reproduction , vol.133 , Issue.6 , pp. 1233-1239
    • Ishikawa, T.1    Harada, T.2    Kubota, T.3    Aso, T.4
  • 47
    • 0028141232 scopus 로고
    • Expression of messenger ribonucleic acid encoding matrix metalloproteinases and their tissue inhibitors is related to menstruation
    • Hampton AL, Salamonsen LA 1994 Expression of messenger ribonucleic acid encoding matrix metalloproteinases and their tissue inhibitors is related to menstruation. J Endocrinol 141:R1-R3
    • (1994) J Endocrinol , vol.141
    • Hampton, A.L.1    Salamonsen, L.A.2
  • 48
    • 0032457024 scopus 로고    scopus 로고
    • Insulin like growth factors in endometrial function
    • Rutanen EM 1998 Insulin-like growth factors in endometrial function. Gynecol Endocrinol 12:399-406 (Pubitemid 29084164)
    • (1998) Gynecological Endocrinology , vol.12 , Issue.6 , pp. 399-406
    • Rutanen, E.-M.1
  • 49
    • 0028173314 scopus 로고
    • Androgen regulation of the insulin-like growth factor-I and the estrogen receptor in rat uterus and liver
    • Sahlin L, Norstedt G, Eriksson H 1994 Androgen regulation of the insulin-like growth factor-I and the estrogen receptor in rat uterus and liver. J Steroid Biochem Mol Biol 51:57-66 (Pubitemid 2156325)
    • (1994) Journal of Steroid Biochemistry and Molecular Biology , vol.51 , Issue.1-2 , pp. 57-66
    • Sahlin, L.1    Norstedt, G.2    Eriksson, H.3
  • 50
    • 0017577604 scopus 로고
    • Effect of androgens on concentration of LH and FSH in the peripheral plasma of anoestrous ewes
    • Pant HC 1977 Effect of androgens on concentration of LH and FSH in the peripheral plasma of anoestrous ewes. J Reprod Fertil 50:133-136 (Pubitemid 8086588)
    • (1977) Journal of Reproduction and Fertility , vol.50 , Issue.1 , pp. 133-136
    • Pant, H.C.1
  • 51
    • 0021249615 scopus 로고
    • Regulation of luteinizing hormone secretion in male sheep by endogenous estrogen
    • Schanbacher BD 1984 Regulation of luteinizing hormone secretion in male sheep by endogenous estrogen. Endocrinology 115:944-950 (Pubitemid 14074459)
    • (1984) Endocrinology , vol.115 , Issue.3 , pp. 944-950
    • Schanbacher, B.D.1
  • 52
    • 0033981232 scopus 로고    scopus 로고
    • Review: Brain aromatization and other factors affecting male reproductive behavior with emphasis on the sexual orientation of rams
    • DOI 10.1016/S0739-7240(99)00065-X, PII S073972409900065X
    • Pinckard KL, Stellflug J, Resko JA, Roselli CE, Stormshak F 2000 Review: brain aromatization and other factors affecting male reproductive behavior with emphasis on the sexual orientation of rams. Domest Anim Endocrinol 18:83-96 (Pubitemid 30104537)
    • (2000) Domestic Animal Endocrinology , vol.18 , Issue.1 , pp. 83-96
    • Pinckard, K.L.1    Stellflug, J.2    Resko, J.A.3    Roselli, C.E.4    Stormshak, F.5
  • 53
    • 0035942522 scopus 로고    scopus 로고
    • Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands
    • Marhefka CA, Moore 2nd BM, Bishop TC, Kirkovsky L, Mukherjee A, Dalton JT, Miller DD 2001 Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands. J Med Chem 44:1729-1740
    • (2001) J Med Chem , vol.44 , pp. 1729-1740
    • Marhefka, C.A.1    Moore II, B.M.2    Bishop, T.C.3    Kirkovsky, L.4    Mukherjee, A.5    Dalton, J.T.6    Miller, D.D.7
  • 54
    • 0030928779 scopus 로고    scopus 로고
    • Endocrine defects in mice carrying a null mutation for the progesterone receptor gene
    • DOI 10.1210/en.138.10.4147
    • Chappell PE, Lydon JP, Conneely OM, O'Malley BW, Levine JE 1997 Endocrine defects in mice carrying a null mutation for the progesterone receptor gene. Endocrinology 138:4147-4152 (Pubitemid 27408454)
    • (1997) Endocrinology , vol.138 , Issue.10 , pp. 4147-4152
    • Chappell, P.E.1    Lydon, J.P.2    Conneely, O.M.3    O'Malley, B.W.4    Levine, J.E.5
  • 55
    • 33745219480 scopus 로고    scopus 로고
    • Testosterone antagonist (flutamide) blocks ovulation and preovulatory surges of progesterone, luteinizing hormone and oestradiol in laying hens
    • DOI 10.1530/rep.1.01067
    • Rangel PL, Sharp PJ, Gutierrez CG 2006 Testosterone antagonist (flutamide) blocks ovulation and preovulatory surges of progesterone, luteinizing hormone and oestradiol in laying hens. Reproduction 131:1109-1114 (Pubitemid 43904984)
    • (2006) Reproduction , vol.131 , Issue.6 , pp. 1109-1114
    • Rangel, P.L.1    Sharp, P.J.2    Gutierrez, C.G.3
  • 56
    • 0022596436 scopus 로고
    • Do androgens directly regulate gonadotropin secretion in the polycystic ovary syndrome?
    • Dunaif A 1986 Do androgens directly regulate gonadotropin secretion in the polycystic ovary syndrome? J Clin Endocrinol Metab 63:215-221
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 215-221
    • Dunaif, A.1
  • 57
    • 0022995743 scopus 로고
    • Acute modulation of the hypothalamic-pituitary axis by intravenous testosterone in normal women
    • Serafini P, Silva PD, Paulson RJ, Elkind-Hirsch K, Hernandez M, Lobo RA 1986 Acute modulation of the hypothalamic-pituitary axis by intravenous testosterone in normal women. Am J Obstet Gynecol 155:1288-1292 (Pubitemid 17201693)
    • (1986) American Journal of Obstetrics and Gynecology , vol.155 , Issue.6 , pp. 1288-1292
    • Serafini, P.1    Silva, P.D.2    Paulson, R.J.3
  • 59
    • 0022526564 scopus 로고
    • Comparative effects of cyproterone acetate or a long-acting gonadotropin-releasing hormone agonist in polycystic ovarian disease
    • Couzinet B, Le SN, Brailly S, Schaison G 1986 Comparative effects of cyproterone acetate or a long-acting gonadotropin-releasing hormone agonist in polycystic ovarian disease. J Clin Endocrinol Metab 63:1031-1035 (Pubitemid 16004314)
    • (1986) Journal of Clinical Endocrinology and Metabolism , vol.63 , Issue.4 , pp. 1031-1035
    • Couzinet, B.1    Le Strat, N.2    Brailly, S.3    Schaison, G.4
  • 60
    • 0034523425 scopus 로고    scopus 로고
    • Polycystic ovarian syndrome: Evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone
    • DOI 10.1210/jc.85.11.4047
    • Eagleson CA, Gingrich MB, Pastor CL, Arora TK, Burt CM, Evans WS, Marshall JC 2000 Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J Clin Endocrinol Metab 85:4047-4052 (Pubitemid 32055351)
    • (2000) Journal of Clinical Endocrinology and Metabolism , vol.85 , Issue.11 , pp. 4047-4052
    • Eagleson, C.A.1    Gingrich, M.B.2    Pastor, C.L.3    Arora, T.K.4    Burt, C.M.5    Evans, W.S.6    Marshall, J.C.7
  • 61
    • 0011113282 scopus 로고
    • The histocompatibility requirements of ovarian grafts in mice
    • Hicken P, Krohn PL 1960 The histocompatibility requirements of ovarian grafts in mice. Proc R Soc Lond B Biol Sci 151:419-433
    • (1960) Proc R Soc Lond B Biol Sci , vol.151 , pp. 419-433
    • Hicken, P.1    Krohn, P.L.2
  • 62
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Franks S 1995 Polycystic ovary syndrome. N Engl J Med 333:853-861
    • (1995) N Engl J Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 63
    • 15444366255 scopus 로고    scopus 로고
    • Polycystic ovary syndrome
    • DOI 10.1056/NEJMra041536
    • Ehrmann DA 2005 Polycystic ovary syndrome. N Engl J Med 352:1223-1236 (Pubitemid 40397264)
    • (2005) New England Journal of Medicine , vol.352 , Issue.12
    • Ehrmann, D.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.