Differential deposition of amyloid β peptides in cerebral amyloid angiopathy associated with Alzheimer's disease and vascular dementia

Acta Neuropathologica

Volumn 111, Issue 5, 2006, Pages 430-435

  Haglund, Mattias ^a   Kalaria, Raj ^b   Slade, Janet Y ^b   Englund, Elisabet ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

Author keywords

Cerebrovascular disorder; Congophilic angiopathy; Dementia; Smooth muscle actin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; CARBOXY TERMINAL TELOPEPTIDE; SMOOTH MUSCLE ACTIN;

ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAIN BIOPSY; CEREBROVASCULAR DISEASE; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KRUSKAL WALLIS TEST; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; MOLECULAR MECHANICS; MULTIINFARCT DEMENTIA; NEUROIMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VASCULAR AMYLOIDOSIS;

ACTINS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN; CEREBRAL AMYLOID ANGIOPATHY; DEMENTIA, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; MUSCLE, SMOOTH, VASCULAR; SEVERITY OF ILLNESS INDEX;

EID: 33646246165     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-006-0054-z     Document Type: Article

References (35)

1. Alonzo NC, Hyman BT, Rebeck GW, Greenberg SM (1998) Progression of cerebral amyloid angiopathy: Accumulation of amyloid-beta40 in affected vessels. J Neuropathol Exp Neurol 57:353-359
2. Attems J (2005) Sporadic cerebral amyloid angiopathy: Pathology, clinical implications, and possible pathomechanisms. Acta Neuropathol 110:345-359
3. Attems J, Lintner F, Jellinger KA (2004) Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology. Acta Neuropathol 107:283-291
4. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239-259
5. Brun A, Englund E (1981) Regional pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading. Histopathology 5:549-564
6. Brun A, Gustafson L (1993) The longitudinal dementia study: A 25-year perspective on neuropathology, differential diagnosis and treatment. In: Corain B, Iqbal K, Nicolini M, Winblad B, Wisniewski H, Zatta P (eds) Alzheimer's disease-advances in clinical and basic research. Wiley, New York, pp 3-18
7. Cadavid D, Mena H, Koeller K, Frommelt RA (2000) Cerebral beta amyloid angiopathy is a risk factor for cerebral ischemic infarction. A case control study in human brain biopsies. J Neuropathol Exp Neurol 59:768-773
8. Eisenhauer PB, Johnson RJ, Wells JM, Davies TA, Fine RE (2000) Toxicity of various amyloid beta peptide species in cultured human blood-brain barrier endothelial cells: Increased toxicity of Dutch-type mutant. J Neurosci Res 60:804-810
9. Fernando MS, Ince PG (2004) MRC Cognitive Function and Ageing Neuropathology Study Group. Vascular pathologies and cognition in a population-based cohort of elderly people. J Neurol Sci 226:13-17
10. Gravina SA, Ho L, Eckman CB, Long KE, Otvos L Jr, Younkin LH, Suzuki N, Younkin SG (1995) Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). J Biol Chem 270:7013-7016
11. Gray F, Dubas F, Roullet E, Escourolle R (1985) Leukoencephalopathy in diffuse hemorrhagic cerebral amyloid angiopathy. Ann Neurol 18:54-59
12. Greenberg SM, Gurol ME, Rosand J, Smith EE (2004) Amyloid angiopathy-related vascular cognitive impairment. Stroke 35:2616-2619
13. Haglund M, Englund E (2002) Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - a histopathological assessment. Dement Geriatr Cogn Disord 14:161-166
14. Haglund M, Sjobeck M, Englund E (2004) Severe cerebral amyloid angiopathy characterizes an underestimated variant of vascular dementia. Dement Geriatr Cogn Disord 18:132-137
15. Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y (1994) Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43). Neuron 13:45-53
16. Jarrett JT, Berger EP, Lansbury PT (1993) The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32:4693-4697
17. Jellinger K (1977) Cerebrovascular amyloidosis with cerebral hemorrhage. J Neurol 214:195-206
18. Kalaria RN, Kenny RA, Ballard CG, Perry R, Ince P, Polvikoski T (2004) Towards defining the neuropathological substrates of vascular dementia. J Neurol Sci 226:75-80
19. Kalaria RN, Thomas A, Oakley A, Ince P, Tamaoka A, Mori H, Kenny RA, Ballard C (2003) Cerebrovascular amyloidosis and dementia. Curr Med Chem Immun Endoc Metab Agents 4:317-327
20. Kawai M, Kalaria RN, Cras P, Siedlak SL, Velasco ME, Shelton ER, Chan HW, Greenberg BD, Perry G (1993) Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Res 623:142-146
21. Mori H, Takio K, Ogawara M, Selkoe DJ (1992) Mass spectrometry of purified amyloid beta protein in Alzheimer's disease. J Biol Chem 267:17082-17086
22. Nicoll JA, Yamada M, Frackowiak J, Mazur-Kolecka B, Weller RO (2004) Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement. Neurobiol Aging 25:589-597
23. Olichney JM, Hansen LA, Hofstetter R, Grundman R, Katzman R, Thal LJ (1995) Cerebral infarction in Alzheimer's disease is associated with severe amyloid angiopathy and hypertension. Arch Neurol 52:702-708
24. Rensink AA, de Waal RM, Kremer B, Verbeek MM (2003) Pathogenesis of cerebral amyloid angiopathy. Brain Res Brain Res Rev 43:207-223
25. Revesz T, Holton JL, Lashley T, Plant G, Rostagno A, Ghiso J, Frangione B (2002) Sporadic and familial cerebral amyloid angiopathies. Brain Pathol 12:343-357
26. Rhodin JA, Thomas TN, Clark L, Garces A, Bryant M (2003) In vivo cerebrovascular actions of amyloid beta-peptides and the protective effect of conjugated estrogens. J Alzheimers Dis 5:275-286
27. Roher AE, Lowenson JD, Clarke S, Wolkow C, Wang R, Cotter RJ, Reardon IM, Zurcher-Neely HA, Heinrikson RL, Ball MJ, Greenberg B (1993) Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease. J Biol Chem 268:3072-3083
28. Sadowski M, Pankiewicz J, Scholtzova H, Li YS, Quartermain D, Duff K, Wisniewski T (2004) Links between the pathology of Alzheimer's disease and vascular dementia. Neurochem Res 29:1257-1266
29. Thomas T, Thomas G, McLendon C, Sutton T, Mullan M (1996) Beta-amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380:168-171
30. Thomas A, Ballard C, Kenny RA, OO'Brien J, Oakley A, Kalaria R (2005) Correlation of entorhinal amyloid with memory in Alzheimer's and vascular but not lewy body dementia. Dement Geriatr Cogn Disord 19:57-60
31. Tian J, Shi J, Bailey K, Mann DM (2003) Negative association between amyloid plaques and cerebral amyloid angiopathy in Alzheimer's disease. Neurosci Lett 352:137-140
32. Verbeek MM, de Waal RM, Schipper JJ, Van Nostrand WE (1997) Rapid degeneration of cultured human brain pericytes by amyloid beta protein. J Neurochem 68:1135-1141
33. Weller RO, Massey A, Newman TA, Hutchings M, Kuo YM, Roher AE (1998) Cerebral amyloid angiopathy: Amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am J Pathol 153:725-733
34. Weller RO, Yow HY, Preston SD, Mazanti I, Nicoll JA (2002) Cerebrovascular disease is a major factor in the failure of elimination of A beta from the aging human brain: Implications for therapy of Alzheimer's disease. Ann N Y Acad Sci 977:162-168
35. Zhang WW, Lempessi H, Olsson Y (1998) Amyloid angiopathy of the human brain: Immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells. Acta Neuropathol 96:558-563