Biofunctionalization of electrospun PCL-based scaffolds with perlecan domain IV peptide to create a 3-D pharmacokinetic cancer model

Biomaterials

Volumn 31, Issue 21, 2010, Pages 5700-5718

  Hartman, Olga ^a   Zhang, Chu ^a   Adams, Elizabeth L ^a   Farach Carson, Mary C ^a,c   Petrelli, Nicholas J ^b   Chase, Bruce D ^a   Rabolt, John F ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b HELEN F GRAHAM CANCER CENTER   (United States)

^c RICE UNIVERSITY   (United States)

Author keywords

Cancer cell adhesion; Composite; Electrospinning; Gelatin; Mechanical properties; Perlecan; Polycaprolactone; Protein attachment

Indexed keywords

CANCER CELL ADHESION; CANCER CELLS; COMPOSITE; GELATIN; PERLECAN; PROTEIN ATTACHMENT;

ADHESION; AMINO ACIDS; BONE; CELL ADHESION; CELLS; ELECTROSPINNING; FUNCTIONAL POLYMERS; MECHANICAL PROPERTIES; PEPTIDES; PHARMACOKINETICS; PHOSPHATASES; PHOSPHORYLATION; POLYCAPROLACTONE; SCAFFOLDS; THREE DIMENSIONAL;

BIOMECHANICS;

FOCAL ADHESION KINASE; GELATIN; MOLECULAR SCAFFOLD; PERLECAN; POLYCAPROLACTONE; POLYMER; PROTEOHEPARAN SULFATE; TYROSINE; UVOMORULIN;

ARTICLE; BIOLOGICAL ACTIVITY; BIOMIMETICS; BONE MARROW; CANCER GROWTH; CANCER INFILTRATION; CANCER MODEL; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; COMPOSITE MATERIAL; CONTROLLED STUDY; ELECTROSPINNING; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; MICROENVIRONMENT; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; STRESS FIBER; TUMOR SEEDING;

BIOCOMPATIBLE MATERIALS; BONE MARROW; CADHERINS; CELL ADHESION; CELL LINE, TUMOR; CELL PROLIFERATION; ELECTROCHEMICAL TECHNIQUES; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GELATIN; HEPARAN SULFATE PROTEOGLYCANS; HUMANS; MALE; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; NEOPLASM METASTASIS; PEPTIDES; POLYESTERS; POROSITY; PROSTATIC NEOPLASMS; TIGHT JUNCTIONS; TISSUE SCAFFOLDS;

EID: 77953024277     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.03.017     Document Type: Article

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