Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling

Angewandte Chemie - International Edition

Volumn 49, Issue 23, 2010, Pages 3934-3938

  Stauch, Benjamin ^a   Simon, Bernd ^a   Basile, Teodora ^a   Schneider, Gisbert ^b   Malek, Nisar P ^c   Kalesse, Markus ^d,e   Carlomagno, Teresa ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b ETH ZURICH   (Switzerland)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^e HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Cancer; Competitive binding; Ligand interactions; Nmr spectroscopy; Proteasomes

Indexed keywords

ANTI-TUMORAL ACTIVITY; BIOLOGICAL ACTIVITIES; CHEMICAL EQUATIONS; COMPETITIVE BINDING; CYCLIC-PEPTIDE INHIBITORS; DRUG TARGETS; HEPTAPEPTIDES; INTERMOLECULAR INTERACTIONS; NATURAL PRODUCTS; NMR SPECTROSCOPY; PROTEASOMES; RELATIONSHIP DATA; STRUCTURAL MODELS; STRUCTURE-ACTIVITY;

LIGANDS; MODEL STRUCTURES;

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANTINEOPLASTIC AGENT; ARGYRIN A; CYCLOPEPTIDE; ENZYME INHIBITOR; PROTEASOME;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PEPTIDES, CYCLIC; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77953012647     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201000140     Document Type: Article

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