Noradrenergic function in pathological gambling: Blunted growth hormone response to clonidine

Journal of Psychopharmacology

Volumn 24, Issue 6, 2010, Pages 847-853

  Pallanti, S ^a,b   Bernardi, S ^a,b   Allen, A ^a   Chaplin, W ^c   Watner, D ^c   Decaria, Cm ^a   Hollander, E ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORENCE   (Italy)

^c ST JOHN'S UNIVERSITY   (United States)

Author keywords

Clonidine; Cortico frontal function; Growth hormone; Impulsivity; Noradrenaline

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; GROWTH HORMONE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GROWTH HORMONE RELEASE; HORMONE RESPONSE; HUMAN; IMPULSIVENESS; LOCUS CERULEUS; MALE; NEUROTRANSMISSION; NORADRENERGIC SYSTEM; PATHOLOGICAL GAMBLING; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; RECEPTOR UPREGULATION; SINGLE DRUG DOSE;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; AREA UNDER CURVE; CLONIDINE; DOUBLE-BLIND METHOD; GAMBLING; HUMAN GROWTH HORMONE; HUMANS; IMPULSE CONTROL DISORDERS; NEUROSECRETORY SYSTEMS; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 77953005252     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881108099419     Document Type: Article

References (49)

1. Abelson, JL, Curtis, GC, Uhde, TW (2005) Twenty-four hour growth hormone secretion in patients with panic disorder. Psychoneuroendocrinology 30: 72-79.
2. Abelson, JL, Glitz, D., Cameron, OG, Lee, MA, Bronzo, M., Curtis, GC (1991) Blunted growth hormone response to clonidine in patients with generalized anxiety disorder. Arch Gen Psychiatry 48: 157-162.
3. Arnsten, AF, Cai, JX, Goldman-Rakic, PS (1988) The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes. J Neurosci 8: 4287-4298.
4. Aston-Jones, G., Bloom, FE (1981) Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J Neurosci 1: 887-900.
5. Aston-Jones, G., Chiang, C., Alexinsky, T. (1991) Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. In: Progress in Brain Research 88: 501-520.
6. Aston-Jones, G., Cohen, JD (2005) Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performance. J Comp Neurol 493: 99-110. (Pubitemid 41637975)
7. Baumann, MH, Milchanowski, AB, Rothman, RB (2004) Evidence for alterations in alpha2-adrenergic receptor sensitivity in rats exposed to repeated cocaine administration. Neuroscience 125: 683-690.
8. Brown, R. (1987) Classical and operant paradigms in the management of gambling addictions. Behav Psychother 15: 111-112.
9. Chamberlain, SR, Muller, U., Blackwell, AD, Robbins, TW, Sahakian, BJ (2006) Noradrenergic modulation of working memory and emotional memory in humans. Psychopharmacology (Berl) 188: 397-407.
10. Charney, DS, Heninger, GR (1986) Abnormal regulation of noradrenergic function in panic disorders. Effects of clonidine in healthy subjects and patients with agoraphobia and panic disorder. Arch Gen Psychiatry 43: 1042-1054.
11. Charney, DS, Heninger, GR, Sternberg, DE (1982) Failure of chronic antidepressant treatment to alter growth hormone response to clonidine. Psychiatry Res 7: 135-138.
12. Clark, CR, Geffen, GM, Geffen, LB (1989) Catecholamines and the covert orientation of attention in humans. Neuropsychologia 27: 131-139.
13. Comings, DE, Johnson, JP, Gonzales, NS, Huss, M., Saucier, G., McGue, M., et al. (2000) Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects. Psychiatr Genet 10: 39-42.
14. Coplan, JD, Papp, LA, Martinez, J., Pine, D., Rosenblum, LA, Cooper, T., et al. (1995) Persistence of blunted growth hormone response to clonidine in fluoxetine-treated patients with panic disorder. Am J Psychiatry 152: 619-622.
15. Eriksson, E., Edén, S., Modigh, K. (1982) Up- and down- regulation of central postsynaptic alpha 2 receptors reflected in the growth hormone response to clonidine in reserpine-pretreated rats. Psychopharmacology (Berl). 77: 327-331.
16. First, MB, Spitzer, RL, Gibbon, M., Williams, JBW (1997) Structured Clinical Interview for DSM-IV Axis I (SCID I). Clinical Version. Washington, DC: American Psychiatric Press.
17. Franken, IH, van Strien, JW, Nijs, I., Muris, P. (2008) Impulsivity is associated with behavioral decision-making deficits. Psychiatry Res 158: 155-163.
18. Franowicz, JS, Kessler, LE, Borja, CM, Kobilka, BK, Limbird, LE, Arnsten, AF (2002) Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. J Neurosci 22: 8771-8777.
19. Fu, CH, Reed, LJ, Meyer, JH, Kennedy, S., Eisfeld, BS, Brown, GM (2001) Noradrenergic dysfunction in the prefrontal cortex in depression: an [15O] H2O PET study of the neuromodulatory effects of clonidine. Biol Psychiatry 49: 317-325.
20. Glass, IB, Checkley, SA, Shur, E., Dawling, S. (1982) The effect of desipramine upon central adrenergic function in depressed patients. Br J Psychiatry 141: 372-376.
21. Goodman, WK, Price, LH, Rasmussen, SA, Mazur, C., Gleischmann, R., Hill, C., et al. (1989) Yale Brown Obsessive-Compulsive Scale (YBOCS) I: development, use and reliability. Arch of Gen Psych 46: 1006-1011.
22. Guerra, G., Zaimovic, A., Moi, G., Bussandri, M. Del signore, R., Caccavari, R., et al. (2003) Neuroendocrine correlates of antisocial personalità disorder in abstinent heroin-dependent subjects. Addict Biol 8: 23-32.
23. Hamilton, M. (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56-62.
24. Haughey, HM, Kaiser, AL, Johnson, TE, Bennett, B., Siklea, JM, Zahniser, NR (2005) Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice. Alcohol Clin Exp Res 29: 1759-1768.
25. Hollander, E., Sood, E., Pallanti, S., Baldini Rossi, N., Baker, B. (2005) Pharmacological treatments of pathological gambling. J Gambl Stud 21: 101-110.
26. Hount, GE, O,Sullivans, BT, Johnson, GF, Smythe, GA (1986) Growth hormone and cortisol secretion after oral clonidine in healthy adults. Psychoendocrinology 11: 317-325.
27. Hurlemann, R., Hawellek, B., Matusch, A., Kolsch, H., Wollersen, H., Madea, B., et al. (2005) Noradrenergic modulation of emotion-induced forgetting and remembering. J Neurosci 25: 6343-6349.
28. Iancu, I., Lowengrub, K., Debinsky, Y., Kotler, M., Dannon, PN (2008) Pathological gambling: an update on neuropathophysiology and pharmacotherapy. CNS Drugs 22: 123-138.
29. Kok, P., Paulo, RC, Cosma, M., Mielke, KL, Miles, JM, Bowers, CY, et al. (2008) Estrogen supplementation selectively enhances hypothalamo-pituitary sensitivity to ghrelin in postmenopausal women. J Clin Endocrinol Metab 93: 4020-4026.
30. Lesieur, H., Blume, SB (1987) The South Oaks Gambling Screen (the SOGS). a new instrument for the identification of pathological gamblers. Am J Psychiatry 144: 1184-1188.
31. Matussek, N., Ackenheil, M., Hippius, H., Muller, F., Schroder, HT, Schultes, H., et al. (1980) Effect of clonidine on growth hormone release in psychiatric patients and controls. Psychiatry Res 2: 25-36.
32. McGaughy, J., Ross, RS, Eichenbaum, H. (2008) Noradrenergic, but not cholinergic, deafferentation of prefrontal cortex impairs attentional set-shifting. Neuroscience 153: 63-71.
33. Meyer, G., Schwertfeger, J., Exton, MS, Janssen, OE, Knapp, W., Stadler, MA, et al. (2004) Neuroendocrine response to casino gambling in problem gamblers. Psychoneuroendocrinology 29: 1272-1280.
34. O,Carroll, RE, Papps, BP (2003) Decision making in humans: the effect of manipulating the central noradrenergic system. J Neurol Neurosurg Psychiatry 74: 376-378.
35. Pallanti, S., Bernardi, S., Quercioli, L., Decaria, C., Hollander, E. (2006) Serotonin dysfunction in pathological gamblers: increased prolactin response to oral m-CPP versus placebo. CNS Spectr 11: 956-964.
36. Pallanti, S., DeCaria, CM, Grant, JE, Urpe, M., Hollander, E. (2005) Reliability and validity of the pathological gambling adaptation of the Yale-Brown Obsessive-Compulsive Scale (PG-YBOCS). J Gambl Stud 21: 431-443.
37. Patton, JH, Stanford, MS, Barrat, ES (1995) Factor structure of the Barratt impulsiveness scale. J Clin Psychol 51: 768-774.
38. Potenza, MN (2001) The neurobiology of pathological gambling. Semin Clin Neuropsychiatry 6: 217-226.
39. Pruessner, JC, Kirschbaum, C., Meinlschmid, G., Hellhammer, DH (2003) Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 28: 916-931.
40. Roy, A., DeJong, J., Linnoila, M. (1989) Extroversion in pathological gamblers: correlates with indexes of noradrenergic function. Arch Gen Psychiatry 46: 679-681.
41. Schittecatte, M., Charles, G., Machowski, R., Dumont, F., Garcia-Valentin, J., Wilmotte, J., et al. (1994) Effects of gender and diagnosis on growth hormone response to clonidine for major depression: a large-scale multicenter study. Am J Psychiatry 151: 216-220.
42. Shaffer, HJ, Korn, DA (2002) Gambling and related mental disorders: a public health analysis. Annu Rev Public Health 23: 171-212.
43. Siever, LJ, Insel, TR, Jimerson, DC, Lake, CR, Uhde, TW, Aloi, J., et al. (1983) Growth hormone response to clonidine in obsessive-compulsive patients. Br J Psychiatry 142: 184-187.
44. Siever, LJ, Uhde, TW (1984) New studies and perspectives on the noradrenergic receptor system in depression: effects of the alpha 2-adrenergic agonist clonidine. Biol Psychiatry 19: 131-156.
45. Spitzer, RL, Williams, JB, Gibbon, M., First, M. (1989) Structured Clinical Interview for DSM III-R Patient Version (SCID-P) for Axis I and Axis II Disorders. New York: Biometrics Research Department, NYS Psychiatric Institute.
46. Tanila, H., Rama, P., Carlson, S. (1996) The effects of prefrontal intra-cortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats. Brain Res Bull 40: 117-119.
47. Uhde, TW, Vittone, BJ, Siever, LJ, Kaye, WH, Post, RM (1986) Blunted growth hormone response to clonidine in panic disorder patients. Biol Psychiatry 21: 1081-1085.
48. Van Cauter, E., Aschoff, T. (1989) In: DeGroot, LT (ed). Endocrinology. Philadelphia: WB Saunders, pp. 2658-2734.
49. Xian, H., Shah, KR, Phillips, SM, Scherrer, JF, Volberg, R., Eisen, SA (2008) Association of cognitive distortions with problem and pathological gambling in adult male twins. Psychiatry Res 160: 300-307.