Norepinephrine transporter: A candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 10, 2005, Pages 1759-1768

  Haughey, Heather M ^a,c   Kaiser, Alan L ^a   Johnson, Thomas E ^c   Bennett, Beth ^c   Sikela, James M ^a,b   Zahniser, Nancy R ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Alcohol sensitivity; Genetics; Loss of righting reflex; Norepinephrine transporter; Quantitative trait loci

Indexed keywords

ALCOHOL; MESSENGER RNA; NISOXETINE; NORADRENALIN; NORADRENALIN TRANSPORTER; TRITIUM;

ALCOHOLISM; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN SYNAPTOSOME; CHROMOSOMAL LOCALIZATION; CONTROLLED STUDY; FEMALE; HAPLOTYPE; HIPPOCAMPUS; HOMOZYGOTE; INBRED STRAIN; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REGRESSION ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIGHTING REFLEX; WILD TYPE;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DNA, COMPLEMENTARY; ETHANOL; FEMALE; FLUOXETINE; MALE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MUSCULOSKELETAL EQUILIBRIUM; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PHENOTYPE; REFLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SLEEP;

ANIMALIA;

EID: 27644514112     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.alc.0000183009.57805.a6     Document Type: Article

References (53)

1. Alkana RL, Finn DA, Bejanian M, Crabbe JC (1988) Genetically determined differences in ethanol sensitivity influenced by body temperature during intoxication. Life Sci 43:1973-1982.
2. Baldwin HA, Wall TL, Schuckit MA, Koob GF (1991) Differential effects of ethanol on punished responding in the P and NP rats. Alcohol Clin Exp Res 15:700-704.
3. Bennett B, Beeson M, Gordon L, Johnson TE (2002) Reciprocal congenics defining individual quantitative trait loci for sedative/hypnotic sensitivity to ethanol. Alcohol Clin Exp Res 26:149-157.
4. Bennett B, Johnson TE (1998) Development of congenics for hypnotic sensitivity to ethanol by QTL-marker-assisted counter selection. Mamm Genome 9:969-974.
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
6. Cooper JR, Bloom FE, Roth RH (2003) The Biochemical Basis of Neuropharmacology. Oxford University Press, New York.
7. Crabbe JC, Gallaher ES, Phillips TJ, Belknap JK (1994) Genetic determinants of sensitivity to ethanol in inbred mice. Behav Neurosci 108:186-195.
8. Dick DM, Foroud T (2003) Candidate genes for alcohol dependence: a review of genetic evidence from human studies. Alcohol Clin Exp Res 27:868-879.
9. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV (2003) Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12:205-216.
10. Dycaico MJ, Felts K, Nichols SW, Geller SA, Sorge JA (1989) Neonatal growth delay in alpha-1-antitrypsin disease: Influence of genetic background. Mol Biol Med 6:137-141.
11. Enoch MA, Goldman D (2001) The genetics of alcoholism and alcohol abuse. Curr Psychiatry Rep 3:144-151.
12. Erwin VG, Su NC (1989) Neurotensin and ethanol interactions on hypothermia and locomotor activity in LS and SS mice. Alcohol Clin Exp Res 13:91-94.
13. Ewing B, Green P (1998) Base-calling of automated sequencer traces using phred, II: Error probabilities. Genome Res 8:186-194.
14. Finn DA, Bejanian M, Jones BL, McGivern RF, Syapin PJ, Crabbe JC, Alkana RL (1990) Body temperature differentially affects ethanol sensitivity in both inbred strains and selected lines of mice. J Pharmacol Exp Ther 253:1229-1235.
15. Franklin KBJ, Paxinos G (1997) The Mouse Brain in Stereotaxic Coordinates. Academic Press, San Diego.
16. Fritz JD, Jayanthi LD, Thoreson MA, Blakely RD (1998) Cloning and chromosomal mapping of the murine norepinephrine transporter. J Neurochem 70:2241-2251.
17. Gill K, Deitrich RA (1998) Acute tolerance to the ataxic effects of ethanol in short-sleep (SS) and long-sleep (LS) mice. Psychopharmacology (Berl) 136:91-98.
18. Gordon D, Abajian C, Green P (1998) Consed: A graphical tool for sequence finishing. Genome Res 8:195-202.
19. Han C, McGue MK, Iacono WG (1999) Lifetime tobacco, alcohol and other substance use in adolescent Minnesota twins: Univariate and multivariate behavioral genetic analyses. Addiction 94:981-993.
20. Haughey HM, Brown JM, Wilkins DG, Hanson GR, Fleckenstein AE (2000) Differential effects of methamphetamine on Na(+)/Cl(-)-dependent transporters. Brain Res 863:59-65.
21. Heath AC, Martin NG (1992) Genetic differences in psychomotor performance decrement after alcohol: a multivariate analysis. J Stud Alcohol 53:262-271.
22. Heston WD, Erwin VG, Andersen SM, Robbins H (1974) A comparison of the effects of ethanol on mice selectively bred for differences in ethanol sleep-time. Life Sci 14:365-370.
23. Howerton TC, Marks MJ, Collins AC (1982) Norepinephrine, gamma-aminobutyric acid, and choline reuptake kinetics and the effects of ethanol in long-sleep and short-sleep mice. Subst Alcohol Actions Misuse 3:89-99.
24. 3H]-tomoxetine. Alcohol Clin Exp Res 24:588-594.
25. Johnson TE, DeFries JC, Markel PD (1992) Mapping quantitative trait loci for behavioral traits in the mouse. Behav Genet 22:635-653.
26. Jones SR, Gainetdinov RR, Jaber M, Giros B, Wightman RM, Caron MG (1998) Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A 95:4029-4034.
27. Kendler KS, Neale MC, Heath AC, Kessler RC, Eaves LJ (1994) A twin-family study of alcoholism in women. Am J Psychiatry 151:707-715.
28. Lee CM, Javitch JA, Snyder SH (1983) Recognition sites for norepinephrine uptake: regulation by neurotransmitter. Science 220:626-629.
29. Letts VA, Schork NJ, Copp AJ, Bernfield M, Frankel WN (1995) A curly-tail modifier locus, mct1, on mouse chromosome 17. Genomics 29:719-724.
30. Li TK (2000) Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking. J Stud Alcohol 61:5-12.
31. Lutz SE, Hilbish TJ, Dewey MJ (1989) Genetic control of juvenile growth rate in mice: variation between a congenic strain and its background strain. J Hered 80:264-267.
32. Madden PA, Heath AC, Starmer GA, Whitfield JB, Martin NG (1995) Alcohol sensitivity and smoking history in men and women. Alcohol Clin Exp Res 19:1111-1120.
33. Markel PD, Bennett B, Beeson M, Gordon L, Johnson TE (1997) Confirmation of quantitative trait loci for ethanol sensitivity in long-sleep and short-sleep mice. Genome Res 7:92-99.
34. Markel PD, DeFries JC, Johnson TE (1995) Use of repeated measures in an analysis of ethanol-induced loss of righting reflex in inbred long-sleep and short-sleep mice. Alcohol Clin Exp Res 19:299-304.
35. Markel PD, Fulker DW, Bennett B, Corley RP, DeFries JC, Erwin VG, Johnson TE (1996) Quantitative trait loci for ethanol sensitivity in the LS x SS recombinant inbred strains: interval mapping. Behav Genet 26:447-458.
36. McClearn GE, Kakihana R (1981) Selective breeding for ethanol sensitivity: short-sleep and long-sleep mice. In: Development of animal models as pharmacogenetic tools. (McClearn, GE, Deitrich RA, and Kakihana, R, eds), pp 147-159. NIAAA Research Monograph, Rockville, MD.
37. Moore MS, DeZazzo J, Luk AY, Tully T, Singh CM, Heberlein U (1998) Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93:997-1007.
38. Nestler EJ, Hyman SE, Malenka RC (2001) Molecular Neurophrmacology: A Foundation for Clinical Neuroscience. McGraw-Hill Publishing Co., New York, NY.
39. Nevo I, Hamon M (1995) Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism. Neurochem Int 26:305-342.
40. Prescott CA, Kendler KS (1999) Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. Am J Psychiatry 156:34-40.
41. Rossetti ZL, Longu G, Mercuro G, Hmaidan Y, Gessa GL (1992) Biphasic effect of ethanol on noradrenaline release in the frontal cortex of awake rats. Alcohol Alcohol 27:477-80.
42. Schuckit MA (1994) Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151:184-189.
43. Schuckit MA, Hesselbrock V, Tipp J, Anthenelli R, Bucholz K, Radziminski S (1994) A comparison of DSM-III-R, DSM-IV and ICD-10 substance use disorders diagnoses in 1922 men and women subjects in the COGA study: Collaborative Study on the Genetics of Alcoholism. Addiction 89:1629-1638.
44. Schuckit MA, Smith TL (1996) An 8-year follow-up of 450 sons of alcoholic and control subjects. Arch Gen Psychiatry 53:202-210.
45. Smolen A, Smolen TN (1987) Demonstration of a threshold concentration for ethanol at the time of regaining the righting response in long-sleep and short-sleep mice. Alcohol Drug Res 7:279-283.
46. Spuhler K, Gerhardt G, Palmer MR (1987) CNS monoamine levels and the effect of DSP4 on ethanol sensitivity in LS and SS mice. Alcohol 4:419-424.
47. Sun AY, Seaman RN, Middleton CC (1977) Effects of acute and chronic alcohol administration on brain membrane transport systems. Adv Exp Med Biol 85A:123-138.
48. Tejani-Butt SM, Brunswick DJ, Frazer A (1990) [3H]nisoxetine: a new radioligand for norepinephrine uptake sites in brain. Eur J Pharmacol 191:239-243.
49. Tyndale RF (2003) Genetics of alcohol and tobacco use in humans. Ann Med 35:94-121.
50. Weinshenker D, Rust NC, Miller NS, Palmiter RD (2000) Ethanol-associated behaviors of mice lacking norepinephrine. J Neurosci 20:3157-3164.
51. Weinshenker D, White SS, Javors MA, Palmiter RD, Szot P (2002) Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo. Brain Res 946:239-246.
52. Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link P, Rikke B, Belknap JK, Johnson TE (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains. Mamm Genome 15:637-647.
53. Xu F, Gainetdinov RR, Wetsel WC, Jones SR, Bohn LM, Miller GW, Wang YM, Caron MG (2000) Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat Neurosci 3:465-471.