메뉴 건너뛰기




Volumn 37, Issue 1, 2010, Pages 109-133

Hereditary Breast and Ovarian Cancer (HBOC): Clinical Features and Counseling for BRCA1 and BRCA2, Lynch Syndrome, Cowden Syndrome, and Li-Fraumeni Syndrome

Author keywords

BRCA1 2; Genetic counseling; Hereditary breast cancer; Hereditary ovarian cancer; Lynch syndrome

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; CHECKPOINT KINASE 2; MISMATCH REPAIR PROTEIN PMS2; PARATHYROID HORMONE RECEPTOR 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE LKB1; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH3; PROTEIN MSH6; PROTEIN P53; PROTEIN PATCHED; UVOMORULIN;

EID: 77952981208     PISSN: 08898545     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ogc.2010.03.003     Document Type: Review
Times cited : (40)

References (61)
  • 1
    • 35348902805 scopus 로고    scopus 로고
    • SGO Committee Statement: Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions
    • Lancaster J.M., Powell C.B., Kauff N.D., et al. SGO Committee Statement: Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. Gynecol Oncol 2007, 107:159-162.
    • (2007) Gynecol Oncol , vol.107 , pp. 159-162
    • Lancaster, J.M.1    Powell, C.B.2    Kauff, N.D.3
  • 2
    • 62749148300 scopus 로고    scopus 로고
    • Hereditary breast and ovarian cancer syndrome
    • ACOG Practice Bulletin
    • ACOG Practice Bulletin Hereditary breast and ovarian cancer syndrome. Gynecol Oncol 2009, 113:6-11.
    • (2009) Gynecol Oncol , vol.113 , pp. 6-11
  • 3
    • 63549096634 scopus 로고    scopus 로고
    • Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management
    • Lynch H.T., Casey M.J., Snyder C.L., et al. Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management. Mol Oncol 2009, 3:97-137.
    • (2009) Mol Oncol , vol.3 , pp. 97-137
    • Lynch, H.T.1    Casey, M.J.2    Snyder, C.L.3
  • 4
    • 3242883102 scopus 로고    scopus 로고
    • Tubal sterilization and risk of ovarian, endometrial and cervical cancer. A Danish population-based follow-up study of more than 65,000 sterilized women
    • Kjaer S.K., Mellemkjaer L., Brinton L.A., et al. Tubal sterilization and risk of ovarian, endometrial and cervical cancer. A Danish population-based follow-up study of more than 65,000 sterilized women. Int J Epidemiol 2004, 33:596-602.
    • (2004) Int J Epidemiol , vol.33 , pp. 596-602
    • Kjaer, S.K.1    Mellemkjaer, L.2    Brinton, L.A.3
  • 5
    • 52049088505 scopus 로고    scopus 로고
    • The relative contribution of point mutations and genomic rearrangements in BRCA1 and BRCA2 in high-risk breast cancer families
    • Palma M.D., Domchek S.M., Stopfer J., et al. The relative contribution of point mutations and genomic rearrangements in BRCA1 and BRCA2 in high-risk breast cancer families. Cancer Res 2008, 68:7006-7014.
    • (2008) Cancer Res , vol.68 , pp. 7006-7014
    • Palma, M.D.1    Domchek, S.M.2    Stopfer, J.3
  • 6
    • 33745877609 scopus 로고    scopus 로고
    • Pitfalls and caveats in BRCA sequencing
    • Bellosillio B., Tusquets I. Pitfalls and caveats in BRCA sequencing. Ultrastruct Pathol 2006, 30:229-235.
    • (2006) Ultrastruct Pathol , vol.30 , pp. 229-235
    • Bellosillio, B.1    Tusquets, I.2
  • 7
    • 0031025322 scopus 로고    scopus 로고
    • Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: results from 3 US population-based case-control studies of ovarian cancer
    • Whittemore A.S., Gong G., Imyre J. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: results from 3 US population-based case-control studies of ovarian cancer. Am J Hum Genet 1997, 60:496-504.
    • (1997) Am J Hum Genet , vol.60 , pp. 496-504
    • Whittemore, A.S.1    Gong, G.2    Imyre, J.3
  • 8
    • 33845654907 scopus 로고    scopus 로고
    • Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a Kin-Cohort Study in Ontario, Canada
    • Risch H.A., McLaughlin J.R., Cole D.E.C., et al. Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a Kin-Cohort Study in Ontario, Canada. J Natl Cancer Inst 2006, 98:1694-1706.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1694-1706
    • Risch, H.A.1    McLaughlin, J.R.2    Cole, D.E.C.3
  • 9
    • 75749096049 scopus 로고    scopus 로고
    • Screening for founder mutations in BRCA1 and BRCA2 in unselected Jewish women
    • Metcalfe K.A., Poll A., Royer R., et al. Screening for founder mutations in BRCA1 and BRCA2 in unselected Jewish women. J Clin Oncol 2010, 28:387-391.
    • (2010) J Clin Oncol , vol.28 , pp. 387-391
    • Metcalfe, K.A.1    Poll, A.2    Royer, R.3
  • 11
    • 50249111103 scopus 로고    scopus 로고
    • A review of the clinical relevance of mismatch-repair deficiency in ovarian cancer
    • Pal T., Permuth-Wey J., Sellers T.A. A review of the clinical relevance of mismatch-repair deficiency in ovarian cancer. Cancer 2008, 113:733-742.
    • (2008) Cancer , vol.113 , pp. 733-742
    • Pal, T.1    Permuth-Wey, J.2    Sellers, T.A.3
  • 12
    • 0001628596 scopus 로고    scopus 로고
    • Familial endometrial cancer in female carriers of MSH6 germline mutations
    • Wijnen J., de Leeuw W., Vasen H., et al. Familial endometrial cancer in female carriers of MSH6 germline mutations. Nat Genet 1999, 23:142-144.
    • (1999) Nat Genet , vol.23 , pp. 142-144
    • Wijnen, J.1    de Leeuw, W.2    Vasen, H.3
  • 13
    • 44949202465 scopus 로고    scopus 로고
    • The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome
    • Watson P., Vasen H.F.A., Mecklin J.-P., et al. The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. Int J Cancer 2008, 123:444-449.
    • (2008) Int J Cancer , vol.123 , pp. 444-449
    • Watson, P.1    Vasen, H.F.A.2    Mecklin, J.-P.3
  • 14
    • 0027158031 scopus 로고
    • Clues to the pathogenesis of familial colorectal cancer
    • Aaltonen L.A., Peltomaki P., Leach F.S., et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993, 260:812-816.
    • (1993) Science , vol.260 , pp. 812-816
    • Aaltonen, L.A.1    Peltomaki, P.2    Leach, F.S.3
  • 15
    • 63549126247 scopus 로고    scopus 로고
    • The contribution of BRCA1 and BRCA2 to ovarian cancer
    • Ramus S.J., Gayther S.A. The contribution of BRCA1 and BRCA2 to ovarian cancer. Mol Oncol 2009, 3:138-150.
    • (2009) Mol Oncol , vol.3 , pp. 138-150
    • Ramus, S.J.1    Gayther, S.A.2
  • 16
    • 0026663495 scopus 로고
    • Hereditary ovarian cancer: a clinicopathological study
    • Bewtra C., Watson P., Conway T., et al. Hereditary ovarian cancer: a clinicopathological study. Int J Gynecol Pathol 1992, 11:180-187.
    • (1992) Int J Gynecol Pathol , vol.11 , pp. 180-187
    • Bewtra, C.1    Watson, P.2    Conway, T.3
  • 17
    • 0033955496 scopus 로고    scopus 로고
    • Risk models for familial ovarian and breast cancer
    • Antoniou A.C., Gayther S.A., Stratton J.F., et al. Risk models for familial ovarian and breast cancer. Genet Epidemiol 2000, 18:173-190.
    • (2000) Genet Epidemiol , vol.18 , pp. 173-190
    • Antoniou, A.C.1    Gayther, S.A.2    Stratton, J.F.3
  • 18
    • 0037130889 scopus 로고    scopus 로고
    • Cancer risk estimates for BRCA1 mutation carriers
    • Brose M.S., Rebbeck T.R., Calzone K.A., et al. Cancer risk estimates for BRCA1 mutation carriers. J Natl Cancer Inst 2002, 94:1365-1372.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1365-1372
    • Brose, M.S.1    Rebbeck, T.R.2    Calzone, K.A.3
  • 19
    • 0033523268 scopus 로고    scopus 로고
    • Cancer risks in BRCA2 mutation carriers
    • The Breast Cancer Linkage Consortium
    • The Breast Cancer Linkage Consortium Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst 1999, 91(15):1310-1316.
    • (1999) J Natl Cancer Inst , vol.91 , Issue.15 , pp. 1310-1316
  • 20
    • 0035098503 scopus 로고    scopus 로고
    • Prevalence and penetrance in germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer
    • Risch H.A., McLaughlin J.R., Cole D.E.C., et al. Prevalence and penetrance in germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet 2001, 68:700-710.
    • (2001) Am J Hum Genet , vol.68 , pp. 700-710
    • Risch, H.A.1    McLaughlin, J.R.2    Cole, D.E.C.3
  • 21
    • 0036900022 scopus 로고    scopus 로고
    • Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations
    • Satagopan J.M., Boyd J., Kauff N.D., et al. Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations. Clin Cancer Res 2002, 8:3776-3781.
    • (2002) Clin Cancer Res , vol.8 , pp. 3776-3781
    • Satagopan, J.M.1    Boyd, J.2    Kauff, N.D.3
  • 22
    • 33846203984 scopus 로고    scopus 로고
    • Cancer risks among BRCA1 and BRCA2 mutation carriers
    • Levy-Lahad E., Friedman E. Cancer risks among BRCA1 and BRCA2 mutation carriers. Br J Cancer 2007, 96:11-15.
    • (2007) Br J Cancer , vol.96 , pp. 11-15
    • Levy-Lahad, E.1    Friedman, E.2
  • 23
    • 53149125656 scopus 로고    scopus 로고
    • Counseling for male BRCA mutation carriers-a review
    • Mohammad H.B., Apffelstaedt J.P. Counseling for male BRCA mutation carriers-a review. Breast 2008, 17:441-450.
    • (2008) Breast , vol.17 , pp. 441-450
    • Mohammad, H.B.1    Apffelstaedt, J.P.2
  • 24
    • 54049130531 scopus 로고    scopus 로고
    • The role of the BRCA2 gene in susceptibility to prostate cancer revisited
    • Ostrander E.A., Udler M.S. The role of the BRCA2 gene in susceptibility to prostate cancer revisited. Cancer Epidemiol Biomarkers Prev 2008, 17:1843-1848.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 1843-1848
    • Ostrander, E.A.1    Udler, M.S.2
  • 25
    • 0037130889 scopus 로고    scopus 로고
    • Cancer risk estimates for BRCA1 mutation carriers identified in a cancer risk evaluation program
    • Brose M., Rebbeck T., Calzone K., et al. Cancer risk estimates for BRCA1 mutation carriers identified in a cancer risk evaluation program. J Natl Cancer Inst 2002, 94:1359-1365.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1359-1365
    • Brose, M.1    Rebbeck, T.2    Calzone, K.3
  • 26
    • 62849118739 scopus 로고    scopus 로고
    • Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate and pancreatic cancers, and melanoma
    • Mai P.L., Chatterjee N., Hartge P., et al. Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate and pancreatic cancers, and melanoma. PLoS One 2009, 4(3):e4812. 10.1371/journal.pone.0004812.
    • (2009) PLoS One , vol.4 , Issue.3
    • Mai, P.L.1    Chatterjee, N.2    Hartge, P.3
  • 27
    • 67650924286 scopus 로고    scopus 로고
    • Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
    • Lynch H.T., Lynch P.M., Lanspa S.J., et al. Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. Clin Genet 2009, 76:1-18.
    • (2009) Clin Genet , vol.76 , pp. 1-18
    • Lynch, H.T.1    Lynch, P.M.2    Lanspa, S.J.3
  • 28
    • 0032941343 scopus 로고    scopus 로고
    • Cancer risk in mutation carriers of DNA mismatch repair genes
    • Aarnio M., Sankila R., Pukkala E., et al. Cancer risk in mutation carriers of DNA mismatch repair genes. Int J Cancer 1999, 81:214-218.
    • (1999) Int J Cancer , vol.81 , pp. 214-218
    • Aarnio, M.1    Sankila, R.2    Pukkala, E.3
  • 29
    • 65949110839 scopus 로고    scopus 로고
    • Endometrial cancer as a familial tumor: pathology and molecular carcinogenesis [review]
    • Banno K., Yanokura M., Kobayashi Y., et al. Endometrial cancer as a familial tumor: pathology and molecular carcinogenesis [review]. Curr Genomics 2009, 10:127-132.
    • (2009) Curr Genomics , vol.10 , pp. 127-132
    • Banno, K.1    Yanokura, M.2    Kobayashi, Y.3
  • 30
    • 42949126666 scopus 로고    scopus 로고
    • Lynch syndrome in women less than 50 years of age with endometrial cancer
    • Mathews K.S., Estes J.M., Connor M.G., et al. Lynch syndrome in women less than 50 years of age with endometrial cancer. Obstet Gynecol 2008, 111:1161-1166.
    • (2008) Obstet Gynecol , vol.111 , pp. 1161-1166
    • Mathews, K.S.1    Estes, J.M.2    Connor, M.G.3
  • 31
    • 33646408125 scopus 로고    scopus 로고
    • The contribution of the hereditary nonpolyposis colorectal cancer syndrome to the development of ovarian cancer
    • Malander S., Rambech E., Kristoffersson U., et al. The contribution of the hereditary nonpolyposis colorectal cancer syndrome to the development of ovarian cancer. Gynecol Oncol 2006, 101:238-243.
    • (2006) Gynecol Oncol , vol.101 , pp. 238-243
    • Malander, S.1    Rambech, E.2    Kristoffersson, U.3
  • 33
    • 28644433009 scopus 로고    scopus 로고
    • Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome
    • Cederquist K., Emanuelsson M., Wiklund F., et al. Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome. Clin Genet 2005, 68:533-541.
    • (2005) Clin Genet , vol.68 , pp. 533-541
    • Cederquist, K.1    Emanuelsson, M.2    Wiklund, F.3
  • 34
    • 57449097359 scopus 로고    scopus 로고
    • Feasibility of screening for Lynch syndrome among patients with colorectal cancer
    • Hampel H., Frankel W.L., Martin E., et al. Feasibility of screening for Lynch syndrome among patients with colorectal cancer. J Clin Oncol 2008, 26:5783-5788.
    • (2008) J Clin Oncol , vol.26 , pp. 5783-5788
    • Hampel, H.1    Frankel, W.L.2    Martin, E.3
  • 35
    • 74149083576 scopus 로고    scopus 로고
    • Breastfeeding and risk of epithelial ovarian cancer
    • Jordan S.K., Siskind V., Green C., et al. Breastfeeding and risk of epithelial ovarian cancer. Cancer Causes Control 2010, 21:109-116.
    • (2010) Cancer Causes Control , vol.21 , pp. 109-116
    • Jordan, S.K.1    Siskind, V.2    Green, C.3
  • 36
    • 74949118129 scopus 로고    scopus 로고
    • Survival analysis of cancer risk reduction strategies for BRCA1/2 mutation carriers
    • Kurian A.W., Sigal B.M., Plevritis S.K. Survival analysis of cancer risk reduction strategies for BRCA1/2 mutation carriers. J Clin Oncol 2010, 28:222-231.
    • (2010) J Clin Oncol , vol.28 , pp. 222-231
    • Kurian, A.W.1    Sigal, B.M.2    Plevritis, S.K.3
  • 37
    • 24644456397 scopus 로고    scopus 로고
    • Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: recommendation statement
    • U.S.Preventive Services Task Force
    • U.S.Preventive Services Task Force Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: recommendation statement. Ann Intern Med 2005, 143:355-361.
    • (2005) Ann Intern Med , vol.143 , pp. 355-361
  • 38
    • 34547797981 scopus 로고    scopus 로고
    • Critical assessment of new risk factors for breast cancer: considerations for development of an improved risk prediction model
    • Santen R.J., Boyd N.F., Chlebowski R.T., et al. Critical assessment of new risk factors for breast cancer: considerations for development of an improved risk prediction model. Endocr Relat Cancer 2007, 14:169-187.
    • (2007) Endocr Relat Cancer , vol.14 , pp. 169-187
    • Santen, R.J.1    Boyd, N.F.2    Chlebowski, R.T.3
  • 39
    • 59449096085 scopus 로고    scopus 로고
    • Consideration of hereditary nonpolyposis colorectal cancer in BRCA mutation-negative familial ovarian cancers
    • South S.A., Vance H., Farrell C., et al. Consideration of hereditary nonpolyposis colorectal cancer in BRCA mutation-negative familial ovarian cancers. Cancer 2009, 115:324-333.
    • (2009) Cancer , vol.115 , pp. 324-333
    • South, S.A.1    Vance, H.2    Farrell, C.3
  • 40
    • 12844266901 scopus 로고    scopus 로고
    • Identification of HNPCC by molecular analysis of colon and endometrial tumors
    • Vasen H.F., Hendriks Y., de Jong A.E., et al. Identification of HNPCC by molecular analysis of colon and endometrial tumors. Dis Markers 2004, 20:207-213.
    • (2004) Dis Markers , vol.20 , pp. 207-213
    • Vasen, H.F.1    Hendriks, Y.2    de Jong, A.E.3
  • 41
    • 67349088318 scopus 로고    scopus 로고
    • Current and emerging trends in Lynch syndrome identification in women with endometrial cancer
    • Resnick K.E., Hampel H., Fishel R., et al. Current and emerging trends in Lynch syndrome identification in women with endometrial cancer. Gynecol Oncol 2009, 114:128-134.
    • (2009) Gynecol Oncol , vol.114 , pp. 128-134
    • Resnick, K.E.1    Hampel, H.2    Fishel, R.3
  • 42
    • 0037609660 scopus 로고    scopus 로고
    • Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers
    • Goodfellow P.J., Buttin B.M., Herzog T.J., et al. Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers. Proc Natl Acad Sci U S A 2003, 100:5908-5913.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5908-5913
    • Goodfellow, P.J.1    Buttin, B.M.2    Herzog, T.J.3
  • 43
    • 35148901553 scopus 로고    scopus 로고
    • Comment on: screening for Lynch syndrome (hereditary nonpolyposis colon cancer) among endometrial cancer patients
    • Hampel H., Panescu J., Lockman J., et al. Comment on: screening for Lynch syndrome (hereditary nonpolyposis colon cancer) among endometrial cancer patients. Cancer Res 2007, 62:9603.
    • (2007) Cancer Res , vol.62 , pp. 9603
    • Hampel, H.1    Panescu, J.2    Lockman, J.3
  • 44
    • 52249093054 scopus 로고    scopus 로고
    • Genetic counseling and testing for common hereditary breast cancer syndromes
    • Allain D.C. Genetic counseling and testing for common hereditary breast cancer syndromes. J Mol Diagn 2008, 10:383-395.
    • (2008) J Mol Diagn , vol.10 , pp. 383-395
    • Allain, D.C.1
  • 45
    • 51849143274 scopus 로고    scopus 로고
    • Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome
    • Orloff M.S., Eng C. Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome. Oncogene 2008, 27:5387-5397.
    • (2008) Oncogene , vol.27 , pp. 5387-5397
    • Orloff, M.S.1    Eng, C.2
  • 46
    • 0033738748 scopus 로고    scopus 로고
    • Will the real Cowden syndrome please stand up: revised diagnostic criteria
    • Eng C. Will the real Cowden syndrome please stand up: revised diagnostic criteria. J Med Genet 2000, 37:828-830.
    • (2000) J Med Genet , vol.37 , pp. 828-830
    • Eng, C.1
  • 47
    • 0041667883 scopus 로고    scopus 로고
    • Advances in female hormonal contraception: current alternatives to oral regimens
    • Shulman L.P. Advances in female hormonal contraception: current alternatives to oral regimens. Treat Endocrinol 2003, 2:247-256.
    • (2003) Treat Endocrinol , vol.2 , pp. 247-256
    • Shulman, L.P.1
  • 48
    • 0026665911 scopus 로고
    • Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients
    • Lustbader E.D., Williams W.R., Bondy M.L., et al. Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients. Am J Hum Genet 1992, 51:344-356.
    • (1992) Am J Hum Genet , vol.51 , pp. 344-356
    • Lustbader, E.D.1    Williams, W.R.2    Bondy, M.L.3
  • 49
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinsler K.W., Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996, 87:159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinsler, K.W.1    Vogelstein, B.2
  • 50
    • 0035522894 scopus 로고    scopus 로고
    • Two genetic hits (more or less) to cancer
    • Knudson A.G. Two genetic hits (more or less) to cancer. Nat Rev Cancer 2001, 1:157-162.
    • (2001) Nat Rev Cancer , vol.1 , pp. 157-162
    • Knudson, A.G.1
  • 51
    • 34547785606 scopus 로고    scopus 로고
    • Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players
    • Spec No 1
    • Rahman N., Scott R.H. Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players. Hum Mol Genet 2007, 16(Spec No 1):R60-R66.
    • (2007) Hum Mol Genet , vol.16
    • Rahman, N.1    Scott, R.H.2
  • 52
    • 63549147327 scopus 로고    scopus 로고
    • Role of genetic polymorphisms and ovarian cancer susceptibility
    • Fasching P.A., Gayther S., Pearce L., et al. Role of genetic polymorphisms and ovarian cancer susceptibility. Mol Oncol 2009, 3:171-181.
    • (2009) Mol Oncol , vol.3 , pp. 171-181
    • Fasching, P.A.1    Gayther, S.2    Pearce, L.3
  • 53
    • 64849114271 scopus 로고    scopus 로고
    • Risk of ovarian cancer in women with first-degree relatives with cancer
    • Søegaard M., Frederiksen K., Jensen A., et al. Risk of ovarian cancer in women with first-degree relatives with cancer. Acta Obstet Gynecol Scand 2009, 88:449-456.
    • (2009) Acta Obstet Gynecol Scand , vol.88 , pp. 449-456
    • Søegaard, M.1    Frederiksen, K.2    Jensen, A.3
  • 54
    • 42149141754 scopus 로고    scopus 로고
    • Cancer risk assessment and the genetic counseling process: using hereditary breast and ovarian cancer as an example
    • Prucka S.K., McIlvried D.E., Korf B.R. Cancer risk assessment and the genetic counseling process: using hereditary breast and ovarian cancer as an example. Med Princ Pract 2008, 17:173-189.
    • (2008) Med Princ Pract , vol.17 , pp. 173-189
    • Prucka, S.K.1    McIlvried, D.E.2    Korf, B.R.3
  • 55
    • 70349449744 scopus 로고    scopus 로고
    • Disparities in BRCA testing: when insurance coverage is not a barrier
    • Olaya W., Esquivel P., Wong J.H., et al. Disparities in BRCA testing: when insurance coverage is not a barrier. Am J Surg 2009, 198:562-565.
    • (2009) Am J Surg , vol.198 , pp. 562-565
    • Olaya, W.1    Esquivel, P.2    Wong, J.H.3
  • 56
    • 56749160290 scopus 로고    scopus 로고
    • Clinically applicable models to characterize BRCA1 and BRCA2 variants of uncertain significance
    • Spearman A.D., Sweet K., Zhou X.-P., et al. Clinically applicable models to characterize BRCA1 and BRCA2 variants of uncertain significance. J Clin Oncol 2008, 26:5393-5400.
    • (2008) J Clin Oncol , vol.26 , pp. 5393-5400
    • Spearman, A.D.1    Sweet, K.2    Zhou, X.-P.3
  • 57
    • 77952985634 scopus 로고    scopus 로고
    • Risk perception after genetic counseling in patients with increased risk of cancer
    • Rantala J., Platten U., Lindgren G., et al. Risk perception after genetic counseling in patients with increased risk of cancer. Hered Cancer Clin Pract 2009, 7:15.
    • (2009) Hered Cancer Clin Pract , vol.7 , pp. 15
    • Rantala, J.1    Platten, U.2    Lindgren, G.3
  • 58
    • 74849110509 scopus 로고    scopus 로고
    • Subjective versus objective risk in genetic counseling for hereditary breast and/or ovarian cancers
    • Caruso A., Vigna C., Marozzo B., et al. Subjective versus objective risk in genetic counseling for hereditary breast and/or ovarian cancers. J Exp Clin Cancer Res 2009, 28:157.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 157
    • Caruso, A.1    Vigna, C.2    Marozzo, B.3
  • 59
    • 77955143064 scopus 로고    scopus 로고
    • The development of a cancer genetic-specific measure of coping: the GRACE
    • Phelps C., Bennett P., Jones H., et al. The development of a cancer genetic-specific measure of coping: the GRACE. Psychooncology 2009, 10.1002/pon.1629.
    • (2009) Psychooncology
    • Phelps, C.1    Bennett, P.2    Jones, H.3
  • 60
    • 77649237442 scopus 로고    scopus 로고
    • Perceptions of high-risk care and barriers to care among women at risk for hereditary breast and ovarian cancer following genetic counseling in the community setting
    • Morgan D., Sylvester H., Lucas F.L., et al. Perceptions of high-risk care and barriers to care among women at risk for hereditary breast and ovarian cancer following genetic counseling in the community setting. J Genet Couns 2009, 10.1007/s10897-009-9261-9.
    • (2009) J Genet Couns
    • Morgan, D.1    Sylvester, H.2    Lucas, F.L.3
  • 61
    • 77955482444 scopus 로고    scopus 로고
    • High-grade breast cancers include both highly sensitive and highly resistant subsets to cytotoxic chemotherapy
    • 2010 F 9, [Epub ahead of print]
    • Osako T., Horii R., Matsuura M., et al. High-grade breast cancers include both highly sensitive and highly resistant subsets to cytotoxic chemotherapy. J Cancer Res Clin Oncol 2010 Feb 9, [Epub ahead of print].
    • J Cancer Res Clin Oncol
    • Osako, T.1    Horii, R.2    Matsuura, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.