In vivo generation of β-cell-like cells from CD34+ cells differentiated from human embryonic stem cells

Experimental Hematology

Volumn 38, Issue 6, 2010, Pages

  Goodrich, A Daisy ^a   Ersek, Adel ^a   Varain, Nicole M ^a   Groza, Daria ^a   Cenariu, Mihai ^a   Thain, David S ^a   Almeida Porada, Graca ^a   Porada, Christopher D ^a   Zanjani, Esmail D ^a  

^a UNIVERSITY OF NEVADA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CD34 ANTIGEN; DNA; INSULIN; MESSENGER RNA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CD34 SELECTION; CELL ACTIVITY; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL POPULATION; CHIMERA; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENDOCRINE CELL; ENGRAFTMENT; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; IN UTERO STEM CELL TRANSPLANTATION; IN VIVO STUDY; MOUSE; NONHUMAN; NORMAL HUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SHEEP;

ANIMALIA; OVIS ARIES;

EID: 77952957930     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2010.03.002     Document Type: Article

References (34)

1. Hanafusa T., Miyazaki A., Miyagawa J., et al. Examination of islets in the pancreas biopsy specimens from newly diagnosed type 1 (insulin-dependent) diabetic patients. Diabetologia 1990, 33:105-111.
2. Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., Butler P.C. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110.
3. Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., et al. Embryonic stem cell lines derived from human blastocysts. Science 1998, 282:1145-1147.
4. Kroon E., Martinson L.A., Kadoya K., et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 2008, 26:443-452.
5. Brolen G.K., Heins N., Edsbagge J., Semb H. Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells. Diabetes 2005, 54:2867-2874.
6. Ku H.T. Minireview: pancreatic progenitor cells-recent studies. Endocrinology 2008, 149:4312-4316.
7. Almeida-Porada G., Porada C.D., Chamberlain J., Torabi A., Zanjani E.D. Formation of human hepatocytes by human hematopoietic stem cells in sheep. Blood 2004, 104:2582-2590.
8. Ianus A., Holz G.G., Theise N.D., Hussain M.A. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003, 111:843-850.
9. Hasegawa Y., Ogihara T., Yamada T., et al. Bone marrow (BM) Transplantation promotes beta-cell regeneration after acute injury through BM cell mobilization. Endocrinology 2007, 148:2006-2015.
10. Hess D., Li L., Martin M., et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 2003, 21:763-770.
11. Choi J.B., Uchino H., Azuma K., et al. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 2003, 46:1366-1374.
12. Lechner A., Yang Y.-G., Blacken R.A., Wang L., Nolan A.L., Habener J.F. No evidence for significant transdifferentiation of bone marrow into pancreatic {beta}-cells in vivo. Diabetes 2004, 53:616-623.
13. Berenson R.J., Andrews R.G., Bensinger W.I., et al. Antigen CD34+ marrow cells engraft lethally irradiated baboons. J Clin Invest 1988, 81:951-955.
14. Kaufman D.S., Hanson E.T., Lewis R.L., Auerbach R., Thomson J.A. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A 2001, 98:10716-10721.
15. Narayan A.D., Chase J.L., Lewis R.L., et al. Human embryonic stem cell-derived hematopoietic cells are capable of engrafting primary as well as secondary fetal sheep recipients. Blood 2006, 107:2180-2183.
16. Puglisi M.A., Giuliani L., Fierabracci A. Identification and characterization of a novel expandable adult stem/progenitor cell population in the human exocrine pancreas. J Endocrinol Invest 2008, 31:563-572.
17. Porada C.D., Park P.J., Almeida-Porada G., et al. Gestational age of recipient determines pattern and level of transgene expression following in utero retroviral gene transfer. Mol Ther 2005, 11:284-293.
18. Yu J., Hu K., Smuga-Otto K., Tian S., et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009, 324:797-801.
19. James D., Levine A.J., Besser D., Hemmati-Brivanlou A. TGF beta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005, 132:1273-1282.
20. D'Amour K.A., Agulnick A.D., Eliazer S., Kelly O.G., Kroon E., Baetge E.E. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 2005, 23:1534-1541.
21. Sanchez D., Figarella C., Marchand-Pinatel S., Bruneau N., Guy-Crotte O. Preferential expression of reg I beta gene in human adult pancreas. Biochem Biophys Res Commun 2001, 284:729-737.
22. Schroeder I.S., Kania G., Blyszczuk P., Wobus A.M. Insulin-producing cells. Methods Enzymol 2006, 418:315-333.
23. Marselli L., Thorne J., Ahn Y.B., et al. Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab 2008, 93:1046-1053.
24. Collins L.S., Dorshkind K. A stromal cell line from myeloid long-term bone marrow cultures can support myelopoiesis and B lymphopoiesis. J Immunol 1987, 138:1082-1087.
25. Kucia M., Ratajczak J., Ratajczak M.Z. Are bone marrow stem cells plastic or heterogenous-that is the question. Exp Hematol 2005, 33:613-623.
26. Leenanuruksa D., McDowell G.H. Development of a radioimmunoassay for plasma C-peptide in sheep: kinetics of C-peptide and effects of exogenous growth hormone and glucose on insulin and C-peptide. Aust J Biol Sci 1988, 41:517-525.
27. Lukinius A., Wilander E., Eriksson B., Oberg K. A chromogranin peptide is co-stored with insulin in the human pancreatic islet B-cell granules. Histochem J 1992, 24:679-684.
28. Billingham R.E., Brent L., Medawar P.B. Actively acquired tolerance of foreign cells. Nature 1953, 172:603-606.
29. Zanjani E.D., Flake A.W., Rice H., Hedrick M., Tavassoli M. Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep. J Clin Invest 1994, 93:1051-1055.
30. Chan J., Waddington S.N., O'Donoghue K., et al. Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse. Stem Cells 2007, 25:875-884.
31. Vodyanik M.A., Bork J.A., Thomson J.A., Slukvin Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood 2005, 105:617-626.
32. Jiang W., Shi Y., Zhao D., et al. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res 2007, 17:333-344.
33. Adams D, McKinley M, Colditz I, Dart C. The sheep. In: ANZCCART, ed. Fact sheets about animals: The University of Adelaide, Australia: ANZCCART; 2009. Fact Sheet A9.
34. Ratzmann K.P., Strese J., Kohnert K.D., Jahr D., Michaelis D. Age-dependent relationship of fasting C-peptide concentration and insulin secretion in non-obese subjects with normal glucose tolerance. Exp Clin Endocrinol 1986, 88:57-63.