Participation of lipid transport and fatty acid metabolism in valproate sodium-induced hepatotoxicity in HepG2 cells

Toxicology in Vitro

Volumn 24, Issue 4, 2010, Pages 1086-1091

  Ji, Qiaoli ^a   Shi, Xiaolian ^a   Lin, Rong ^a   Mao, Youhua ^b   Zhai, Xiaogang ^b   Lin, Qinqin ^a   Zhang, Jiye ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b Shaanxi's Tiansen Drug Research and Development Limited Company   (China)

Author keywords

Fatty acid metabolism; Hepatotoxicity; HepG2; Lipid transport; Valproate sodium; VPA

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ABC TRANSPORTER G1; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE I; CYTOCHROME P450 1A1; FATTY ACID; LACTATE DEHYDROGENASE; VALPROIC ACID;

ARTICLE; CARCINOMA CELL; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME RELEASE; FATTY ACID METABOLISM; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIPID TRANSPORT; LIVER TOXICITY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECTROPHOTOMETRY; UPREGULATION;

ALANINE TRANSAMINASE; ANTICONVULSANTS; ASPARTATE AMINOTRANSFERASES; ATP-BINDING CASSETTE TRANSPORTERS; CARNITINE O-PALMITOYLTRANSFERASE; CELL SURVIVAL; CYTOCHROME P-450 CYP1A1; FATTY ACIDS; GENE EXPRESSION; HEP G2 CELLS; HUMANS; L-LACTATE DEHYDROGENASE; LIPID METABOLISM; LIVER; TOXICITY TESTS; VALPROIC ACID;

EID: 77952955675     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.03.014     Document Type: Article

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