P450-catalyzed in-chain desaturation of valproic acid: Isoform selectivity and mechanism of formation of δ3-valproic acid generated by baculovirus-expressed CYP3A1

Archives of Biochemistry and Biophysics

Volumn 356, Issue 1, 1998, Pages 63-70

  Fisher, Michael B ^a   Thompson, Stella J ^a   Ribeiro, Vera ^b   Lechner, Maria C ^b   Rettie, Allan E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

Baculovirus; Cytochrome P450; Dehydrogenation; Mechanism; Microsomes

Indexed keywords

ACYL COENZYME A DESATURASE; ANTICONVULSIVE AGENT; COMPLEMENTARY DNA; CYTOCHROME P450; DEUTERIUM; DRUG METABOLITE; VALPROIC ACID;

ANTICONVULSANT THERAPY; ARTICLE; BACULOVIRUS; CATALYSIS; DRUG METABOLISM; ENZYME ACTIVITY; FATTY ACID DESATURATION; GENE EXPRESSION; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; VIRUS RECOMBINANT;

INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 0032147090     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1998.0742     Document Type: Article

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