Male axillary extracts modify the affinity of the platelet serotonin transporter and impulsiveness in women

Physiology and Behavior

Volumn 100, Issue 4, 2010, Pages 364-368

  Marazziti, Donatella ^a   Masala, Irene ^a   Baroni, Stefano ^a   Polini, Margherita ^a   Massimetti, Gabriele ^a   Giannaccini, Gino ^a   Betti, Laura ^a   Italiani, Paola ^a   Fabbrini, Laura ^a   Caglieresi, Carolina ^b   Moschini, Cecilia ^b   Canale, Domenico ^b   Lucacchini, Antonio ^a   Mauri, Mauro ^a  

^a Dipartimento di Psichiatria Neurobiologia   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

3H 5 HT reuptake; 3H paroxetine binding; Healthy women; Impulsiveness; Male axillary extracts; Romantic attachment; Serotonin transporter

Indexed keywords

PHEROMONE; SEROTONIN TRANSPORTER; TISSUE EXTRACT;

ADULT; ANXIETY; ARTICLE; ATTENTION; AXILLA; CONTROLLED STUDY; DISSOCIATION CONSTANT; FEMALE; HUMAN; HUMAN EXPERIMENT; IMPULSIVENESS; MOTOR PERFORMANCE; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; ODOR; PRIORITY JOURNAL; SELF CONTROL; THROMBOCYTE MEMBRANE; BINDING COMPETITION; COMPARATIVE STUDY; DRUG EFFECTS; MALE; METABOLISM; PSYCHOLOGIC TEST; QUESTIONNAIRE; YOUNG ADULT;

ADULT; AXILLA; BINDING, COMPETITIVE; FEMALE; HUMANS; IMPULSIVE BEHAVIOR; MALE; PSYCHOLOGICAL TESTS; QUESTIONNAIRES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TISSUE EXTRACTS; YOUNG ADULT;

EID: 77952954159     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2010.03.013     Document Type: Article

References (54)

1. Karlson P., Luscher M. 'Pheromones': a new term for a class of biologically active substances. Nature 1959, 183:55-56.
2. Regnier F.E., Law J.H. Insect pheromones. J. Lipid. Res. 1968, 9(5):541-551.
3. Marchlewska-Koj A., Lepri J.J., Muller-Schwarze D. Chemical signals in vertebrates 2001, vol. 9. Kluwer Academic Publishers/Plenum Press, Dordrecht.
4. Doty R.L. Mammalian pheromones: fact or fantasy?. Handbook of Olfaction and Gustation 2003, 38-345. Marcel Dekker Inc. R.L. Doty (Ed.).
5. Brennan P.A., Keverne E.B. Something in the air? New insights into mammalian pheromones. Curr Biol. 2004, 14(2):81-89.
6. Burger B.V. Mammalian semiochemicals. Topics Curr. Chem. 2005, 240:231-278.
7. Brennan P.A., Zufall F. Pheromonal communication in vertebrates. Nature. 2006, 444:308-315.
8. Stowers L., Marton T.F. What is a pheromone?. Mammalian pheromones reconsidered. Neuron 2005, 46:699-702.
9. Kohl J.V., Atzmueller M., Fink B., Grammer K. Human pheromones: integrating neuroendocrinology and ethology. Neuroendocrinol. Lett. 2001, 22(5):309-321.
10. Grammer K., Fink B., Neave N. Human pheromones and sexual attraction. Eur J Obstet Gynecol Reprod Biol 2005, 118(2):135-142.
11. Wysocki C.J., Preti G. Facts, fallacies, fears, and frustrations with human pheromones. Anat. Rec. A. Discov. Mol. Cell. Evol. Biol 2004, 281(1):1201-1211.
12. Leyden J.J., McGinley K.J., Hölzle E., Labows J.N., Kligman A.M. The microbiology of the human axilla and its relationship to axillary odor. Invest. Dermatol. 1981, 77(5):413-416.
13. Zeng C., Spielman A.I., Vowels B.R., Leyden J.J., Biemann K., Preti G. A human axillary odorant is carried by apolipoprotein D. Proc Natl Acad Sci USA 1996, 93(13):6626-6630.
14. Grosser B.I., Monti-Bloch L., Jennings-White C., Berliner D.L. Behavioral and electrophysiological effects of androstadienone, a human pheromone. Psychoneuroendocrinology. 2000, 25(3):289-299.
15. Wyart C., Webster W.W., Chen J.H., Wilson S.R., McClary A., Khan R.M., Sobel N. Smelling a single component of male sweat alters levels of cortisol in women. J. Neurosci. 2007, 27(6):1261-1265.
16. Bensafi M., Brown W.M., Khan R., Levenson B., Sobel N. Sniffing human sex-steroid derived compounds modulates mood, memory and autonomic nervous system function in specific behavioral contexts. Behav Brain Res 2004, 152(1):11-22.
17. McClintock M.K. Menstrual synchrony and suppression. Nature. 1971, 229:244-245.
18. Stern K., McClintock M.K. Regulation of ovulation by human pheromones. Nature 1998, 392:177-179.
19. Preti G., Wysocki C.J., Barnhart K.T., Sondheimer S.J., Leyden J.J. Male axillary extracts contain pheromones that affect pulsatile secretion of luteinizing hormone and mood in women recipients. Biol Reprod 2003, 68(6):2107-2113.
20. Bensafi M., Brown W.M., Tsutsui T., Mainland J.D., Johnson B.N., Bremner E.A., Young N., Mauss I., Ray B., Gross J., Richards J., Stappen I., Levenson R.W., Sobel N. Sex-steroid derived compounds induce sex-specific effects on autonomic nervous system function in humans. Behav Neurosci 2003, 117(6):1125-1134.
21. Van Toller C., Kirk-Smith M., Lombard J., Dodd G.H. Skin conductance and subjective assessments associated with the odour of 5a-androstan-3-one. Biol Psychol 1983, 16:85-107.
22. Benton D. The influence of androstenol, a putative human pheromone on mood throughout the menstrual cycle. Biol Psychol 1982, 15:249-256.
23. Chen D., Haviland-Jones J. Rapid mood change and human odors. Physiol Behav 1999, 68(1-2):241-250.
24. Jacob S., McClintock M.K. Psychological state and mood effects of steroidal chemosignals in women and men. Horm Behav 2000, 37(1):57-78.
25. Lundström J.N., Goncalves M., Esteves F., Olsson M.J. Psychological effects of subthreshold exposure to the putative human pheromone 4, 16-androstadien-3-one. Horm Behav 2003, 44(5):395-401.
26. Kirk-Smith M., Booth M.A., Carroll D., Davies P. Human social attitudes affected by androstenol. Res. Comm. Psych. Psychiat. Behav. 1978, 3:379-384.
27. Savic I., Berglund H., Gulyas B., Roland P. Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron. 2001, 31:661-668.
28. Savic I., Berglund H., Lindström P. Brain response to putative pheromones in homosexual men. Proc. Natl. Acad. Sci. U S A. 2005, 102(20):7356-7731.
29. Lundström J.N., Olsson M.J. Subthreshold amounts of social odorant affect mood, but not behavior, in heterosexual women when tested by a male, but not a female, experimenter. Biol Psychol 2005, 70(3):197-204.
30. Lundström J.N., Hummel T., Olsson M.J. Individual differences in sensitivity to the odor of 4, 16-androstadien-3-one. Chem Senses 2003, 28(7):643-650.
31. Wysocki C.J., Preti G. Pheromonal influences. Arch Sex Behav 1998, 27(6):627-634.
32. Winman A. Do perfume additives termed human pheromones warrant being termed pheromones?. Physiol Behav 2004, 82(4):697-701.
33. Hummer T.A., McClintock M.K. Putative human pheromone androstadienone attunes the mind specifically to emotional information. Horm Behav 2009, 55:548-559.
34. Stahl S.M. Essential neuropsychopharmacology - neuroscientific basis and pratical applications 1998, Cambridge University Press, Cambridge.
35. Lesch K.P., Wolozin B.L., Murphy D.L., Reiderer P. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J. Neurochem. 1993, 60:2319-2322.
36. Rausch J.L., Johnson M.E., Li J., Hutcheson J., Carr B.M., Corley K.M., Gowans A.B., Smith J. Serotonin transport kinetics correlated between human platelets and brain synaptosomes. Psychopharmacology 2005, 180:391-398.
37. 123I]-ADAM SPECT and serotonergic measurements in platelets. Neurosci Lett 2006, 406:153-158.
38. Nakatani Y., Sato-Suzuki I., Tsujino N., Nakasato A., Seki Y., Fumoto M., Arita H. Augmented brain 5-HT crosses the blood-brain barrier through the 5-HT transporter in rat. Eur J NeuroSci 2008, 27:2466-2472.
39. Cupello A., Albano C., Gatta E., Scarrone S., Villa E., Zona G. Binding of paroxetine to the serotonin transporter in membranes from different cells, subcellular fractions and species. Neurochem Res 2009, 34:255-259.
40. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID I), Clinical Version 1997, Washington, DC, American Psychiatric Association.
41. Brennan K.A., Clark C.L., Shaver P.R. Self-report measurement of adult attachment: an integrative overview. Attachment theory and close relationships 1998, 46-76. Guilford Press, New York. J.A. Simpson, W.S. Rholes (Eds.).
42. Patton J.H., Stanford M.S., Barratt E.S. Factor structure of the Barratt impulsiveness scale. J. Clin. Psychol. 1995, 51(6):768-774.
43. Fossati A., Di Ceglie A., Acquarini E., Barratt E.S. Psychometric properties of an Italian version of the Barratt Impulsiveness Scale-11 (BIS-11) in non-clinical subjects. J. Clin. Psychol. 2001, 57(6):815-828.
44. Dell'Osso L., Armani A., Rucci P., Frank E., Fagiolini A., Corretti G., Shear M.K., Grochocinski V.J., Maser J.D., Endicott J., Cassano G.B. Measuring mood spectrum: comparison of interview (SCI-MOODS) and self-report (MOODS-SR) instruments. Compr Psychiatry 2002, 43(1):69-73.
45. Picardi A., Bitetti D., Puddu P., Pasquini P. La scala "Experiences in Close Relationships" (ECR), un nuovo strumento per la valutazione dell'attaccamento negli adulti: traduzione, adattamento e validazione della versione italiana. Rivista di Psichiatria. 2000, 35:114-123.
46. 3H-paroxetine binding in obsessive-compulsive patients. Neuropsychobiology. 1996, 34:184-187.
47. Peterson G.L.A. simplification of the protein assay method that is more generally applicable. Anal Biochem 1977, 83:346-356.
48. Marazziti D., Rossi A., Masala I., Rotondo A., Palego L., Mazzoni M., Giannaccini G., Lucacchini A., Cassano G.B. Regulation of the platelet serotonin transporter by protein kinase C in the young and elderly. Biol Psychiatry 1999, 45(4):443-447.
49. Coccaro E.F., Kavoussi R.J., Sheline Y.I., Lish J.D., Csernansky J.G. Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Arch Gen Psychiatry 1996, 53(6):531-536.
50. Clark L., Roiser J.P., Cools R., Rubinsztein D.C., Sahakian B.J., Robbins T.W. Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsiveness. Psychopharmacology 2005, 182:570-578.
51. Brocke B., Armbruster D., Muller J., Hensch T., Jacob C.P., Lesch K.P., Kirschbaum C., Strobel A. Serotonin transporter gene variation impacts innate fear processing: acoustic startle response and emotional startle. Mol. Psychiatry. 2006, 12:1106-1112.
52. Mazzanti C.M., Lappalainen J., Long J.C., Bengel D., Naukkarinen H., Eggert M., Virkkunen M., Linnoila M., Goldman D. Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Arch Gen Psychiatry 1998, 10:936-940.
53. Aggleton J.P. The contribution of the amygdala to normal and abnormal emotional states. Trends Neurosci 1993, 8:328-333.
54. Risold P.Y., Swanson L.W. Evidence for a hypothalamo-thalamo-cortical circuit mediating pheromonal influences on eye and head movements. Proc Natl Acad Sci USA 1995, 9:3898-3902.