Synovial fluid proteins differentiate between the subtypes of juvenile idiopathic arthritis

Arthritis and Rheumatism

Volumn 62, Issue 6, 2010, Pages 1813-1823

  Rosenkranz, Margalit E ^a   Wilson, David C ^a   Marinov, Anthony D ^a   Decewicz, Alisha ^b   Grof Tisza, Patrick ^b   Kirchner, David ^b   Giles, Brendan ^c   Reynolds, Paul R ^c   Liebman, Michael N ^b   Kolli, V S Kumar ^b   Thompson, Susan D ^d   Hirsch, Raphael ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b WINDBER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; GOLD; HYDROXYCHLOROQUINE; LEFLUNOMIDE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE; RNA; SALAZOSULFAPYRIDINE;

ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DISEASE CLASSIFICATION; FEMALE; HUMAN; JUVENILE RHEUMATOID ARTHRITIS; MALE; MASS SPECTROMETRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SYNOVIAL FLUID; SYNOVIAL FLUID LEVEL; SYNOVIOCYTE; SYNOVIUM; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ADOLESCENT; ARTHRITIS, JUVENILE RHEUMATOID; CHILD; CHILD, PRESCHOOL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; PROTEOME; PROTEOMICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYNOVIAL FLUID;

EID: 77952939018     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27447     Document Type: Article

References (50)

1. Brewer EJ Jr, Bass J, Baum J, Cassidy JT, Fink C, Jacobs J, et al. Current proposed revision of JRA criteria. Arthritis Rheum 1977;20 Suppl 2:195-199
2. De Benedetti F, Ravelli A, Martini A. Cytokines in juvenile rheumatoid arthritis. Curr Opin Rheumatol 1997;9:428-433
3. Glass DN, Giannini EH. Juvenile rheumatoid arthritis as a complex genetic trait [review]. Arthritis Rheum 1999;42:2261-2268 (Pubitemid 30333403)
4. Murray KJ, Grom AA, Thompson SD, Lieuwen D, Passo MH, Glass DN. Contrasting cytokine profiles in the synovium of different forms of juvenile rheumatoid arthritis and juvenile spondyloarthropathy: prominence of interleukin 4 in restricted disease. J Rheumatol 1998;25:1388-1398 (Pubitemid 28312360)
5. + T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4:IFN-γ mRNA ratios. J Immunol 2001;166: 6899-6906
6. Sinz A, Bantscheff M, Mikkat S, Ringel B, Drynda S, Kekow J, et al. Mass spectrometric proteome analyses of synovial fluids and plasmas from patients suffering from rheumatoid arthritis and comparison to reactive arthritis or osteoarthritis. Electrophoresis 2002;23:3445-3456 (Pubitemid 35230230)
7. Liao H, Wu J, Kuhn E, Chin W, Chang B, Jones MD, et al. Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis. Arthritis Rheum 2004;50:3792-3803 (Pubitemid 39643926)
8. Tilleman K, van Beneden K, Dhondt A, Hoffman I, De Keyser F, Veys E, et al. Chronically inflamed synovium from spondyloarthropathy and rheumatoid arthritis investigated by protein expression profiling followed by tandem mass spectrometry. Proteomics 2005;5:2247-2257 (Pubitemid 40770586)
9. Gibson DS, Blelock S, Brockbank S, Curry J, Healy A, McAllister C, et al. Proteomic analysis of recurrent joint inflammation in juvenile idiopathic arthritis. J Proteome Res 2006;5:1988-1995 (Pubitemid 44232711)
10. Gibson DS, Blelock S, Curry J, Finnegan S, Healy A, Scaife C, et al. Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis: proteomic patterns of joint inflammation in early stage disease. J Proteomics 2009;72:656-676
11. Zhang X, Guo Y, Song Y, Sun W, Yu C, Zhao X, et al. Proteomic analysis of individual variation in normal livers of human beings using difference gel electrophoresis. Proteomics 2006;6:5260-5268 (Pubitemid 44547164)
12. Diz AP, Truebano M, Skibinski DO. The consequences of sample pooling in proteomics: an empirical study. Electrophoresis 2009; 30:2967-2975
13. Ryu OH, Atkinson JC, Hoehn GT, Illei GG, Hart TC. Identification of parotid salivary biomarkers in Sjogren's syndrome by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry and two-dimensional difference gel electrophoresis. Rheumatology (Oxford) 2006;45:1077-1086
14. Brown LM, Helmke SM, Hunsucker SW, Netea-Maier RT, Chiang SA, Heinz DE, et al. Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue. Mol Carcinog 2006;45:613-626
15. Ramachandra Rao SP, Wassell R, Shaw MA, Sharma K. Profiling of human mesangial cell subproteomes reveals a role for calmodulin in glucose uptake. Am J Physiol Renal Physiol 2007;292: F1182-9.
16. Tombran-Tink J, Chader GG, Johnson LV. PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity. Exp Eye Res 1991;53:411-414
17. Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W, et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999;285:245-248 (Pubitemid 29329995)
18. Ek ET, Dass CR, Choong PF. PEDF: a potential molecular therapeutic target with multiple anti-cancer activities. Trends Mol Med 2006;12:497-502. (Pubitemid 44468197)
19. Zhang SX, Wang JJ, Gao G, Shao C, Mott R, Ma JX. Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor. FASEB J 2006;20:323-325 (Pubitemid 46671158)
20. Hedbom E, Antonsson P, Hjerpe A, Aeschlimann D, Paulsson M, Rosa-Pimentel E, et al. Cartilage matrix proteins: an acidic oligomeric protein (COMP) detected only in cartilage. J Biol Chem 1992;267:6132-6136
21. Neidhart M, Hauser N, Paulsson M, DiCesare PE, Michel BA, Hauselmann HJ. Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation. Br J Rheumatol 1997;36:1151-1160 (Pubitemid 28080489)
22. Saxne T, Heinegard D. Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood. Br J Rheumatol 1992;31:583-591
23. Gilliam BE, Chauhan AK, Low JM, Moore TL. Measurement of biomarkers in juvenile idiopathic arthritis patients and their significant association with disease severity: a comparative study. Clin Exp Rheumatol 2008;26:492-497
24. 2-macroglobulin. Osteoarthritis Cartilage 2008;16:1413-1420
25. Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, et al. Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes. J Biol Chem 2004;279:17554-17561 (Pubitemid 38560519)
26. Navab M, Ananthramaiah GM, Reddy ST, van Lenten BJ, Ansell BJ, Fonarow GC, et al. The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res 2004;45: 993-1007. (Pubitemid 38679495)
27. Hyka N, Dayer JM, Modoux C, Kohno T, Edwards CK III, Roux-Lombard P, et al. Apolipoprotein A-I inhibits the production of interleukin-1β and tumor necrosis factor-α by blocking contact-mediated activation of monocytes by T lymphocytes. Blood 2001;97:2381-2389 (Pubitemid 32291485)
28. Wadham C, Albanese N, Roberts J, Wang L, Bagley CJ, Gamble JR, et al. High-density lipoproteins neutralize C-reactive protein proinflammatory activity. Circulation 2004;109:2116-2122 (Pubitemid 38620221)
29. Bresnihan B, Gogarty M, FitzGerald O, Dayer JM, Burger D. Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production? Arthritis Res Ther 2004;6:R563-6.
30. Melsom RD, Horsfall AC, Schrieber L, Charles P, Maini RN. Anti-C1q affinity isolated circulating immune complexes correlate with extra-articular rheumatoid disease. Rheumatol Int 1986;6: 227-231
31. Moore TL, Sheridan PW, Traycoff RB, Zuckner J, Dorner RW. Immune complexes in juvenile rheumatoid arthritis: a comparison of four methods. J Rheumatol 1982;9:395-401. (Pubitemid 13229492)
32. Low JM, Chauhan AK, Gibson DS, Zhu M, Chen S, Rooney ME, et al. Proteomic analysis of circulating immune complexes in juvenile idiopathic arthritis reveals disease associated proteins. Proteomics Clin Appl 2009;3:829-840
33. Melamed-Frank M, Lache O, Enav BI, Szafranek T, Levy NS, Ricklis RM, et al. Structure-function analysis of the antioxidant properties of haptoglobin. Blood 2001;98:3693-3698
34. Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, et al. Identification of the haemoglobin scavenger receptor. Nature 2001;409:198-201.
35. Hadchouel M, Prieur AM, Griscelli C. Acute hemorrhagic, hepatic, and neurologic manifestations in juvenile rheumatoid arthritis: possible relationship to drugs or infection. J Pediatr 1985;106: 561-566 (Pubitemid 15080542)
36. Bleesing J, Prada A, Siegel DM, Villanueva J, Olson J, Ilowite NT, et al. The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor α-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis. Arthritis Rheum 2007;56:965-971 (Pubitemid 46399444)
37. Schaer DJ, Schleiffenbaum B, Kurrer M, Imhof A, Bachli E, Fehr J, et al. Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome. Eur J Haematol 2005;74:6-10. (Pubitemid 40143680)
38. Fall N, Barnes M, Thornton S, Luyrink L, Olson J, Ilowite NT, et al. Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome. Arthritis Rheum 2007;56:3793-3804
39. Oliviero S, Cortese R. The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6. EMBO J 1989;8:1145-1151 (Pubitemid 19273282)
40. Frohlander N, Ljunggren O, Lerner UH. Haptoglobin synergistically potentiates bradykinin and thrombin induced prostaglandin biosynthesis in isolated osteoblasts. Biochem Biophys Res Commun 1991;178:343-351
41. Lerner UH, Frohlander N. Haptoglobin-stimulated bone resorption in neonatal mouse calvarial bones in vitro. Arthritis Rheum 1992;35:587-591
42. De Kleijn DP, Smeets MB, Kemmeren PP, Lim SK, van Middelaar BJ, Velema E, et al. Acute-phase protein haptoglobin is a cell migration factor involved in arterial restructuring. FASEB J 2002;16:1123-1125
43. Guetta J, Strauss M, Levy NS, Fahoum L, Levy AP. Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin. Atherosclerosis 2007;191:48-53. (Pubitemid 46227428)
44. Friedrichs WE, Navarijo-Ashbaugh AL, Bowman BH, Yang F. Expression and inflammatory regulation of haptoglobin gene in adipocytes. Biochem Biophys Res Commun 1995;209:250-256
45. Yang F, Ghio AJ, Herbert DC, Weaker FJ, Walter CA, Coalson JJ. Pulmonary expression of the human haptoglobin gene. Am J Respir Cell Mol Biol 2000;23:277-282
46. Yang F, Friedrichs WE, Navarijo-Ashbaugh AL, deGraffenried LA, Bowman BH, Coalson JJ. Cell type-specific and inflammatory-induced expression of haptoglobin gene in lung. Lab Invest 1995;73: 433-440
47. D'Armiento J, Dalal SS, Chada K. Tissue, temporal and inducible expression pattern of haptoglobin in mice. Gene 1997;195:19-27. (Pubitemid 27336956)
48. Li P, Gao XH, Chen HD, Zhang Y, Wang Y, Wang H, et al. Localization of haptoglobin in normal human skin and some skin diseases. Int J Dermatol 2005;44:280-284 (Pubitemid 40542141)
49. Neuhaus OW, Sogoian VP. Presence of haptoglobin in synovial fluid. Nature 1961;192:558-559
50. Smeets MB, Fontijn J, Kavelaars A, Pasterkamp G, De Kleijn DP. The acute phase protein haptoglobin is locally expressed in arthritic and oncological tissues. Int J Exp Pathol 2003;84:69-74. (Pubitemid 36754271)