Drug management in emergent liver transplantation of mitochondrial disorder carriers: Review of the literature

Clinical Transplantation

Volumn 24, Issue 2, 2010, Pages

  Vater, Youri ^a   Dembo, Gregory ^a   Martay, Kenneth ^a   Klein, Yifat ^b   Vitin, Alex ^a   Weinbroum, Avi A ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Anesthesia drug safety; Liver failure; Mitochondrial disorders; Perioperative care; Transplantation

Indexed keywords

ANESTHETIC AGENT; INHALATION ANESTHETIC AGENT; INTRAVENOUS ANESTHETIC AGENT; LOCAL ANESTHETIC AGENT; MUSCLE RELAXANT AGENT; PROPOFOL; SEDATIVE AGENT;

ARTICLE; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL FEATURE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG SENSITIVITY; HEART DISEASE; HUMAN; LIVER FUNCTION; LIVER GRAFT; LIVER METABOLISM; MITOCHONDRIAL RESPIRATORY CHAIN DISORDER; MUSCLE HYPOTONIA; MUSCLE RELAXATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PATHOPHYSIOLOGY; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SIDE EFFECT;

ANESTHESIA; EMERGENCY MEDICAL SERVICES; HUMANS; LIVER TRANSPLANTATION; MITOCHONDRIAL DISEASES; NERVOUS SYSTEM DISEASES; STRESS, PHYSIOLOGICAL;

EID: 77952926522     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2009.01203.x     Document Type: Article

References (108)

1. Clay AS, Behnia M, Brown K. Mitochondrial disease: a pulmonary and critical-care medicine perspective. Chest 2001, 120:634.
2. Zeviani M, Carelli V. Mitochondrial disorders. Curr Opin Neurol 2007, 20:564.
3. Zeviani M, Di Donato S. Mitochondrial disorders. Brain 2004, 127:2153.
4. Schon EA, DiMauro S. Medicinal and genetic approaches to the treatment of mitochondrial disease. Curr Med Chem 2003, 10:2523.
5. DiMauro S, Schon E. Mitochondrial respiratory chain diseases. N Engl J Med 2003, 348:2656.
6. Naguib M, Lien CA. Pharmacology of Muscle Relaxants and Their Antagonists, Anesthesia 2005, Miller RD, 6th edn, ed, New York, Churchill Livingstone
7. Skladal D, Halliday J, Thorburn DR. Minimum birth prevalence of mitochondrial respiratory chain disorders in children. Brain 2003, 126:1905.
8. Wallace D, Lott M, Torroni A, Brown M. Report on the committee on human mitochondrial DNA. Genome Prior Rep 1993, 1:727.
9. Servidei S. Mitochondrial encephalomyopathies: gene mutation. Neuromuscul Disord 1997, 7:XIII.
10. DiMauro S. Mitochondrial myopathies. Curr Opin Rheumatol 2006, 18:636.
11. DiMauro S, Schon EA. Mitochondrial disorders in the nervous system. Annu Rev Neurosci 2008, 31:91.
12. Oldfors A, Tulinius M. Mitochondrial encephalomyopathies. Handb Clin Neurol 2007, 86:125.
13. Morava E, van den Heuvel L, Hol F. Mitochondrial disease criteria: diagnostic applications in children. Neurology 2006, 67:1823.
14. Sasano N, Fujita Y, So M, Sobue K, Sasano H, Katsuya H. Anesthetic management of a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) during laparotomy. J Anesth 2007, 21:72.
15. Melacini P, Gambino A, Caforio A. Heart transplantation in patients with inherited myopathies associated with end-stage cardiomyopathy: molecular and biochemical defects on cardiac and skeletal muscle. Transplant Proc 2001, 33:1596.
16. Tranchant C, Mousson B, Mohr M. Cardiac transplantation in an incomplete Kearns-Sayre syndrome with mitochondrial DNA deletion. Neuromuscul Disord 1993, 3:561.
17. Scheers I, Bachy V, Stephenne X, Sokal EM. Risk of hepatocellular carcinoma in liver mitochondrial respiratory chain disorders. J Pediatr 2005, 146:414.
18. McFarland R, Taylor RW, Turnbull DM. Mitochondrial disease - its impact, etiology, and pathology. Curr Top Dev Biol 2007, 77:113.
19. Ortiz-Gomez JR, Souto-Ferro JM. Anesthesia for a patient with mitochondrial respiratory chain complex III deficiency. Rev Esp Anestesiol Reanim 2006, 53:575.
20. Taanman JW, Rahman S, Pagnamenta AT. Analysis of mutant DNA polymerase gamma in patients with mitochondrial DNA depletion. Hum Mutat 2009, 30:248.
21. Muravchick S. Clinical implications of mitochondrial disease. Adv Drug Deliv Rev 2008, 60:1553.
22. Thajeb P, Dai DF. Current opinion on the clinical approach to the diagnosis of mitochondrial disease. Int J Gerontol 2007, 1:22.
23. Dimauro S. Mitochondrial diseases. Biochim Biophys Acta 2004, 1658:80.
24. Shipton EA, Prosser O. Mitochondrial myopathies and anaesthesia. Eur J Anaesthesiol 2004, 21:173.
25. Thompson VA, Wahr JA. Anesthetic considerations in patients presenting with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (Melas) syndrome. Anesth Analg 1997, 85:1404.
26. Bolton P, Peutrelli J, Zuberi S, Robinson P. Anaesthesia for an adolescent with mitochondrial encephalopathy-lactic acidosis-stroke-like episodes syndrome. Paediatr Anaesth 2003, 13:453.
27. Vydt TC, de Coo RF, Soliman OI. Cardiac involvement in adults with m.3243A>G MELAS gene mutation. Am J Cardiol 2007, 99:264.
28. Bonnet D, Rustin P, Roting A. Heart transplantation in children with mitochondrial cardiomyopathy. Heart 2001, 86:570.
29. Bhati RS, Sheridan BC, Mill MR, Selzman CH. Heart transplantation for progressive cardiomyopathy as a manifestation of MELAS syndrome. J Heart Lung Transplant 2005, 24:2286.
30. Deschauer M, Tennant S, Rokicka A. MELAS associated with mutations in the POLG1 gene. Neurology 2007, 68:1741.
31. Kelly DA. Liver transplantation: to do or not to do? Pediatr Transplant 2000, 4:170.
32. Shneider BL. Pediatric liver transplantation in metabolic disease: clinical decision making. Pediatr Transplant 2002, 6:25.
33. Sztajnkrycer MD. Valproic acid toxicity: overview and management. J Toxicol Clin Toxicol 2002, 40:789.
34. Zucker AR, Gondolesi GE, Abbott MA, Decker R, Rosengren SS, Fishbein TM. Liver-intestine transplant from a pediatric donor with unrecognized mitochondrial succinate cytochrome C reductase deficiency. Transplantation 2005, 79:356.
35. Dubern B, Broue P, Dubuisson C. Orthotopic liver transplantation for mitochondrial respiratory chain disorders: a study of 5 children. Transplantation 2001, 71:633.
36. Kayihan N, Nennesmi I, Ericzon B-G, Nemeth A. Fatal deterioration of neurological disease after orthotopic liver transplantation for VPA-induced liver damage. Pediatr Transplant 2000, 4:211.
37. Morris AA. Mitochondrial respiratory chain disorders and the liver. Liver 1999, 19:357.
38. Ruiteneek W, Wendel U, Trijbels F, Sengers R. Mitochondrial energy metabolism. Physican's Guide to the Laboratory Diagnosis of Metabolic Diseases 1996, 391. Blau N, Duran M, Blaskovics ME, In, eds, London, Chapman & Hall
39. Simonati A, Filosto M, Savio C. Features of cell in brain and liver, the target tissues of progressive neuronal degeneration of childhood with liver disease (Alpers-Huttenlocher disease). Acta Neuropathol 2003, 106:57.
40. Chinnery PF, Turnbull DM. Mitochondrial medicine. QJM 1997, 90:657.
41. Rustin P, Lebidois J, Chretien D. Endomyocardial biopsies for early detection of mitochondrial disorders in hypertrophic cardiomyopathies. J Pediatr 1994, 124:224.
42. Delarue A, Paut O, Guys JM. Inappropriate liver transplantation in a child with Alpers-Huttenlocker syndrome misdiagnosed as valproate-induced acute liver failure. Pediatr Transplant 2000, 4:67.
43. Gordon N. Alpers syndrome: progressive neuronal degeneration of children with liver disease. Dev Med Child Neurol 2006, 48:1001.
44. Dimauro S, Mancuso M. Mitochondrial diseases: therapeutic approaches. Biosci Rep 2007, 27:125.
45. Dhawan A, Mieli-Vergani G. Liver transplantation for mitochondrial respiratory chain disorders: to be or not to be? Transplantation 2001, 71:596.
46. Fernández JA, Robles R, Marín C. Fulminant hepatic failure and liver transplantation: experience of Virgen de la Arrixaca Hospital. Transplant Proc 2003, 35:1852.
47. Sokal EM, Sokol R, Cormier V. Liver transplantation in mitochondrial respiratory chain disorders. Eur J Pediatr 1999, 158(Suppl. 2):S81.
48. Thomson M, Mckiernan P, Buckels J, Mayer D, Kelly D. Generalized mitochondrial cytopathy is an absolute contraindication to orthotopic liver transplantation in childhood. J Pediatr Gastroenterol Nutr 1998, 26:478.
49. United Network for Organ Sharing: Organ Donation and Transplantation http://www.unos.org/data, In, Available at: Accessed January 1, 2010
50. Rake JP, van Spronsen FJ, Visser G. End-stage liver disease as the only consequence of a mitochondrial respiratory chain deficiency: no contra-indication for liver transplantation. Eur J Pediatr 2000, 159:523.
51. Kelly D. Liver transplantation in children. J Pediatr (Rio J) 2008, 84:381.
52. Rasmussen M, Sanengen T, Skullerud K, Kvittingen E. Evidence the Alpers-Huttenlocher syndrome could be a mitochondrial disease. J Child Neurol 2000, 15:473.
53. Vater Y, Dembo G, Klein Y. Perioperative care in Alpers syndrome carrier: case presentation and literature survey. Am J Case Rep 2009, 10:155.
54. Cohen BH, Shoffner J, Deboer G. Anesthesia and Mitochondrial Cytopathies 1998, Monroeville (PA), United Mitochondrial Disease Foundation
55. Casta A, Qqackenbush EJ, Houck CS, Korson MS. Perioperative white matter degeneration and death in a patient with a defect in mitochondrial oxidative phosphorylation. Anesthesiology 1997, 87:420.
56. Grattan-Smith PJ, Shield LK, Hopkins IJ, Collins KJ. Acute respiratory failure precipitated by general anaesthesia in Leigh's syndrome. J Child Neurol 1990, 5:137.
57. Kuhnick H, Wunder C, Roewer WN. Anaesthetic considerations for a 2 month-old infant with suspected complex I respiratory chain deficiency. Paediatr Anaesth 2003, 13:83.
58. Breuking E, Mortier W, Lampert R, Brandt L. Anesthesia and intensive therapy for a patient with mitochondrial myopathy. Anaesthesist 1993, 42:719.
59. Finsterer J, Stratil U, Bittner R, Sporn P. Increased sensitivity to rocuronium and atracurium in mitochondrial myopathy. Can J Anaesth 1998, 45:781.
60. Hsiao PN, Cheng YJ, Tseng HC, Chuang YH. Spinal anesthesia in MELAS syndrome: a case with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes. Acta Anaesthesiol Sin 2000, 38:107.
61. Burns AM, Shelly MP. Anaesthesia for patients with mitochondrial myopathy. Anaesthesia 1989, 44:975.
62. Kushinata T, Yatsu Y, Kubota T, Matsuki A. Total intravenous anesthesia with propofol, ketamine and fentanyl (PFK) for a patient with mitochondrial myopathy. Masui 2004, 53:178.
63. Klockgether-Radke A, Henze T, Braun U, Kettler D. General anesthesia in two patients with mitochondrial myopathy. Anaesthesist 1993, 42:111.
64. Morgan P, Hoppel C, Sedensky M. Mitochondrial defects and anesthetic sensitivity. Anesthesiology 2002, 96:1268.
65. Ishiguro M, Hashimoto K, Hayakata Y, Fukunaga S, Seo N. Prolonged respiratory depression after fentanyl administration in a patient with mitochondrial encephalomyopathy. Masui 2006, 55:73.
66. Sharma AD, Erb T, Schulman SR, Sreeram G, Slaughter TF. Anaesthetic considerations for a child with combined Prader-Willi syndrome and mitochondrial myopathy. Paediatr Anaesth 2001, 11:488.
67. Itaya K, Takahata O, Mamiya K. Anesthetic management of two patients with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Masui 1995, 44:710.
68. Leonard JV, Schapira AH. Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects. Lancet 2000, 355:389.
69. Leonard JV, Schapira AH. Mitochondrial respiratory chain disorders I: mitochondrial DNA defects. Lancet 2000, 355:299.
70. Lee Y, Cchung C, Oh Y-S. Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats. J Korean Med Sci 2000, 15:627.
71. Wolf A, Weir P, Segar P, Stone J. Impaired fatty acid oxidation in propofol infusion syndrome. Lancet 2001, 357:606.
72. Kerz T, Hennes HJ, Fève A, Decq P, Filipetti P, Duvaldestin P. Effects of propofol on H-reflex in humans. Anesthesiology 2001, 94:32.
73. Dueck MH, Oberthuer A, Wedekind C, Paul M, Boerner U. Propofol impairs the central but not the peripheral part of the motor system. Anesth Analg 2003, 96:449.
74. Tatsumi Y, Nakashima M, Kitao T. Anesthetic management of a patient with mitochondrial encephalopathy under total intravenous anesthesia. Masui 2006, 55:1228.
75. Sabaté S, Ferrándiz M, Paniagua P, Villamor JM, Vilanova F, Villar-Landeira JM. Anesthesia in Kearns-Sayre syndrome (mitochondrial myopathy). Rev Esp Anestesiol Reanim 1996, 43:255.
76. Parke TJ, Stevens JE, Rice AS. Metabolic acidosis and fatal myocardial failure after propofol infusion in children five case reports. BMJ 1992, 305:613.
77. Rajda C, Dereczyk D, Kunkel P. Propofol infusion syndrome. J Trauma Nurs 2008, 15:118.
78. Uezono S, Hotta Y, Takakuwa Y, Ozaki M. Acquired carnitine deficiency: a clinical model for propofol infusion syndrome? Anesthesiology 2005, 103:909.
79. Kam PC, Cardone D. Propofol infusion syndrome. Anaesthesia 2007, 62:690.
80. Murayama T, Sato Y, Wainai T, Enomoto A. Effect of continuous infusion of propofol on its concentration in blood with and without the liver in pigs. Transplant Proc 2005, 37:4567.
81. Thiel A, Ritzka M, Saur G. Anesthesia in mitochondrial encephalopathies. Anasthesiol Intensivmed Notfallmed Schmerzther 2001, 36:437.
82. Vilela H, Garcìa-Fernández J, Parodi E, Reinoso-Barbero F, Durán P, Gilsanz F. Anesthetic management of a patient with MERRF syndrome. Paediatr Anaesth 2005, 15:77.
83. Shibukawa K, Kawamata M, Seki S, Narimatsu E, Namiki A. The use of propofol combined with nitrous oxide and fentanyl in anesthetic management of a patient with mitochondrial encephalopathy. Masui 2002, 51:888.
84. Gale T, Leslie K, Kluger M. Propofol anaesthesia via target controlled infusion or manually controlled infusion: effects on the bispectral index as a measure of anaesthetic depth. Anaesth Intensive Care 2001, 29:579.
85. Hara K, Sata T, Shigematsu A. Anesthetic management for cardioverter-defibrillator implantation in a patient with Kearns-Sayre syndrome. J Clin Anesth 2004, 16:539.
86. Wisely NA, Cook PR. General anaesthesia in a man with mitochondrial myopathy undergoing eye surgery. Eur J Anaesthesiol 2001, 18:333.
87. van Dongen EP, ter Beek HT, Schepens MA. The influence of nitrous oxide to supplement fentanyl/low-dose propofol anesthesia on transcranial myogenic motor-evoked potentials during thoracic aortic surgery. J Cardiothorac Vasc Anesth 1999, 13:30.
88. Kakinohana M, Fuchigami T, Nakamura S, Kawabata T, Sugahara K. Propofol reduces spinal motor neuron excitability in humans. Anesth Analg 2002, 94:1586.
89. Höcker J, Tonner PH, Böllert P. Propofol/remifentanil vs sevoflurane/remifentanil for long lasting surgical procedures: a randomised controlled trial. Anaesthesia 2006, 61:752.
90. Mishra LD, Rajkumar N, Hamock SM. Current controversies in neuroanaesthesia, head injury management and neurocritical care. Contin Edu Anaesth, Crit Care Pain 2006, 6:79.
91. Aouad MT, Gerges FJ, Baraka AS. Resistance to cisatracurium in a patient with MELAS syndrome. Paediatr Anaesth 2005, 15:1124.
92. Sjao H, Li J, Zhou Y. Dose-dependent protective effect of propofol against mitochondrial dysfunction in ischaemic/reperfused rat heart: role of cardiolipin. Br J Pharmacol 2008, 153:1641.
93. Heinke W, Schferanietz L. Anaesthesia for combined pancreatic and renal transplantation in a patient with mitochondrial encephalopathy. Case report. Anaesthesiol Reanim 2004, 29:87.
94. Matsbuara S, Okada T, Yoshida M. Mitochondrial changes in acute myopathy after treatment of respiratory failure with mechanical ventilation (acute relaxant-steroid myopathy). Acta Neuropathol 1994, 88:475.
95. Wallace JJ, Pendt H, Skinner M. Anaesthesia and mitochondrial disease. Paediatr Anaesth 1998, 8:249.
96. Park GR, Evans TN, Hutchins J, Borissov B, Gunning KE, Klinck JR. Reducing the demand for admission to intensive care after major abdominal surgery by a change in anaesthetic practice and the use of remifentanil. Eur J Anaesthesiol 2000, 17:111.
97. Cammu G, Decruyenaere J, Troisi R, de Hemptinne B, Colardyn F, Mortier E. Criteria for immediate postoperative extubation in adult recipients following living-related liver transplantation with total intravenous anesthesia. J Clin Anesth 2003, 15:515.
98. Allison KR. Muscular dystrophy versus mitochondrial myopathy: the dilemma of the undiagnosed hypotonic child. Paediatr Anaesth 2007, 17:1.
99. Cheam EW, Critchley LA. Anesthesia for a child with complex I respiratory chain enzyme deficiency. J Clin Anesth 1998, 10:524.
100. Izuta S, Yaku H, Kiyonari Y, Maekawa N, Obara H. Anesthetic management of a patient with mitochondrial encephalomyopathy. Masui 2000, 49:649.
101. Rosaeg OP, Morrison S, Macleod JP. Anaesthetic management of labour and delivery in the parturient with mitochondrial myopathy. Can J Anaesth 1996, 43:403.
102. Falk MJ, Kayser EB, Morgan PG, Sedensky MM. Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans. Curr Biol 2006, 16:1641.
103. Fricker RM, Raffelsberger T, Rauch-Shorny S. Positive malignant hyperthermia susceptibility in vitro test in a patient with mitochondrial myopathy and myoadenylate deaminase deficiency. Anesthesiology 2002, 97:1635.
104. Kayser EB, Morgan PG, Sedensky MM. Mitochondrial complex I function affects halothane sensitivity in Caenorhabditis elegans. Anesthesiology 2004, 101:365.
105. Muravchick S, Levy RJ. Clinical implications of mitochondrial dysfunction. Anesthesiology 2006, 105:819.
106. Becker GL, Pelligrino DA, Miletich DJ, Albrecht RF. The effects of nitrous oxide on oxygen consumption by isolated cerebral cortex mitochondria. Anesth Analg 1986, 65:355.
107. Jurkat-Rott K, McCarthy T, Lehmann-Horn F. Genetics and pathogenesis of malignant hyperthermia. Muscle Nerve 2000, 23:4.
108. Farag E, Argalious M, Narouze S, DeBoer GE, Tome J. The anesthetic management of ventricular septal defect (VSD) repair in a child with mitochondrial cytopathy. Can J Anaesth 2002, 49:958.