Pak3 inhibits local actin filament formation to regulate global cell polarity

HFSP Journal

Volumn 3, Issue 3, 2009, Pages 194-203

  Asano, Y ^a   Jimenez Dalmaroni A ^a   Liverpool, T B ^b   Marchetti, M C ^c   Giomi, L ^c   Kiger, A ^d   Duke, T ^a   Baum, B ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c SYRACUSE UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 77952900221     PISSN: 19552068     EISSN: 1955205X     Source Type: Journal    
DOI: 10.2976/1.3100548     Document Type: Article

References (39)

1. Ang, LH, Kim, J, Stepensky, V, and Hing, H (2003). "Dock and Pak regulate olfactory axon pathfinding in Drosophila." Development 130, 1307-1316.
2. Arias-Romero, LE, and Chernoff, J (2008). "A tale of two Paks." Biol. Cell 100, 97-108.
3. Baum, B and Cherbas, L (2008). "Drosophila cell lines as model systems and as an experimental tool." Methods Mol. Biol. 420, 391-424.
4. Cau, J, and Hall, A (2005). "Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways." J. Cell. Sci. 118, 2579-2587.
5. Cramer, LP (1999). "Organization and polarity of actin filament networks in cells: implications for the mechanism of myosin-based cell motility." Biochem. Soc. Symp. 65, 173-205.
6. de Gennes, PG, and Prost, J (1993). The Physics of Liquid Crystals, Clarendon Press, Oxford.
7. Devreotes, P, and Janetopoulos, C (2003). "Eukaryotic chemotaxis: distinctions between directional sensing and polarization." J. Biol. Chem. 278, 20445-20448.
8. Dobereiner, HG, Dubin-Thaler, BJ, Hofman, JM, Xenias, HS, Sims, TN, Giannone, G, Dustin, ML, Wiggins, CH, and Sheetz, MP (2006). "Lateral membrane waves constitute a universal dynamic pattern of motile cells." Phys. Rev. Lett. 97, 038102.
9. See EPAPS Document No. E-HJFOA5-3-006904 for supplemental material. This document can be reached through a direct link in the online article's HTML reference section or via the EPAPS homepage (http://www.aip.org/pubservs/epaps/html).
10. Giannone, G, et al. (2007). "Lamellipodial actin mechanically links myosin activity with adhesion-site formation." Cell 128, 561-575.
11. Hing, H, Xiao, J, Harden, N, Lim, L, and Zipursky, SL (1999). "Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila." Cell 97, 853-863.
12. Hofmann, C, Shepelev, M, and Chernoff, J (2004). "The genetics of Pak." J. Cell Sci. 117, 4343-4354.
13. Jovceva, E, Larsen, MR, Waterfield, MD, Baum, B, and Timms, JF (2007). "Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis." J. Cell. Sci. 120, 1888-1897.
14. Keren, K, Pincus, Z, Allen, GM, Barnhart, EL, Marriott, G, Mogilner, A, and Theriot, JA (2008). "Mechanism of shape determination in motile cells." Nature (London) 453, 475-480.
15. Kiger, AA, Baum, B, Jones, S, Jones, MR, Coulson, A, Echeverri, C, and Perrimon, N (2003). "A functional genomic analysis of cell morphology using RNA interference." J. Biol. 2, 27.
16. Kono, K, Matsunaga, R, Hirata, A, Suzuki, G, Abe, M, and Ohya, Y (2005). "Involvement of actin and polarisome in morphological change during spore germination of Saccharomyces cerevisiae." Yeast 22, 129-139.
17. Kozlov, MM, and Mogilner, A (2007). "Model of polarization and bistability of cell fragments." Biophys. J. 93, 3811-3819.
18. Kozubowski, L, Saito, K, Johnson, JM, Howell, AS, Zyla, TR, and Lew, DJ (2008). "Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex." Curr. Biol., 18, 1719-1726.
19. Kunda, P, Craig, G, Dominguez, V, and Baum, B (2003). "Abi, Sra1, and Kette control the stability and localisation of SCAR/WAVE to regulate the formation of actin-based protrusions." Curr. Biol. 13, 1867-1875.
20. Lacayo, CI, Pincus, Z, VanDuijn, MM, Wilson, CA, Fletcher, DA, Gertler, FB, Mogilner, A, and Theriot, JA (2007). "Emergence of large-scale cell morphology and movement from local actin filament growth dynamics." PLoS Biol. 5, e233.
21. Liu, T, Sims, D, and Baum, B (2009). "Parallel RNAi screens across different cell lines identify generic and cell-type specific regulators of actin organisation and cell morphology." Genome Biol., 10, R26.
22. Liverpool, TB (2006). "Active gels: where polymer physics meets cytoskeletal dynamics." Philos. Trans. R. Soc. London 364, 3335-3355.
23. Machacek, M, and Danuser, G (2006). "Morphodynamic profiling of protrusion phenotypes." Biophys. J. 90, 1439-1452.
24. Maree, AF, Jilkine, A, Dawes, A, Grieneisen, VA, and Edelstein-Keshet, L (2006). "Polarisation and movement of keratocytes: a multiscale modelling approach." Bull. Math. Biol. 68, 1169-1211.
25. Mentzel, B, and Raabe, T (2005). "Phylogenetic and structural analysis of the Drosophila melanogaster p21-activated kinase DmPAK3." Gene 349, 25-33.
26. Newsome, TP, Schmidt, S, Dietzl, G, Keleman, K, Asling, B, Debant, A, and Dickson, BJ (2000). "Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila." Cell 101, 283-294.
27. Pollard, TD, and Borisy, GG (2003). "Cellular motility driven by assembly and disassembly of actin filaments." Cell 112, 453-465.
28. Ridley, AJ (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking." Trends Cell Biol. 16, 522-529.
29. Rogers, SL, Wiedemann, U, Stuurman, N, and Vale, RD (2003). "Molecular requirements for actin-based lamella formation in Drosophila S2 cells." J. Cell Biol. 162, 1079-1088.
30. Sawin, KE, Hajibagheri, MA, and Nurse, P (1999). "Mis-specification of cortical identity in a fission yeast PAK, mutant." Curr. Biol. 9, 1335-1338.
31. Shlomovitz, R, and Gov, NS (2007). "Membrane waves driven by actin and myosin." Phys. Rev. Lett. 98, 168103.
32. Smith, SD, Jaffer, ZM, Chernoff, J, and Ridley, AJ (2008). "PAK1- mediated activation of ERK1/2 regulates lamellipodial dynamics." J. Cell. Sci. 121, 3729-3736.
33. ten Klooster, JP, Jaffer, ZM, Chernoff, J, and Hordijk, PL (2006). "Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix." J. Cell Biol. 172, 759-769.
34. Verkhovsky, AB, Svitkina, TM, and Borisy, GG (1999). "Self-polarization and directional motility of cytoplasm." Curr. Biol. 9, 11-20.
35. Wedlich-Soldner, R, Altschuler, S, Wu, L, and Li, R (2003). "Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase." Science 299, 1231-1215.
36. Weiner, OD, Marganski, WA, Wu, LF, Altschuler, SJ, and Kirschner, MW (2007). "An actin-based wave generator organizes cell motility." PLoS Biol. 5, e221.
37. Weiner, OD, Rentel, MC, Ott, A, Brown, GE, Jedrychowski, M, Yaffe, MB, Gygi, SP, Cantley, LC, Bourne, HR, and Kirschner, MW (2006). "Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis." PLoS Biol. 4, e38.
38. Weisz Hubsman, M, Volinsky, N, Manser, E, Yablonski, D, and Aronheim, A (2007). "Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp." Biochem. J., 44, 487-497.
39. Xu, J, Wang, F, Van Keymeulen, A, Herzmark, P, Straight, A, Kelly, K, Takuwa, Y, Sugimoto, N, Mitchison, T, and Bourne, HR (2003). "Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils." Cell 114, 201-214.