Insulin stabilizes microvascular endothelial barrier function via phosphatidylinositol 3-kinase/Akt-mediated Rac1 activation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 6, 2010, Pages 1237-1245

  Gündüz, Dursun ^a,c   Thom, Johannes ^a   Hussain, Imran ^a   Lopez, Diego ^b   Härtel, Frauke V ^b   Erdogan, Ali ^a   Grebe, Mathias ^a   Sedding, Daniel ^a   Piper, Hans Michael ^b   Tillmanns, Harald ^a   Noll, Thomas ^b   Aslam, Muhammad ^b  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Capillary permeability; Coronary circulation; Endothelium; Nitric oxide; Vascular biology

Indexed keywords

ACTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GENISTEIN; GUANYLATE CYCLASE; HYDROXY 2 NAPHTHALENYLMETHYLPHOSPHONIC ACID TRIS ACETOXYMETHYL ESTER; INSULIN; INSULIN RECEPTOR; MYOSIN LIGHT CHAIN; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; RAC1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CAPILLARY PERMEABILITY; CELL ADHESION; CELL FUNCTION; CELL JUNCTION; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HORMONAL REGULATION; HORMONE ACTION; IMMUNOPRECIPITATION; MALE; MEMBRANE STABILIZATION; MOLECULAR DYNAMICS; MOLECULAR STABILITY; MONOLAYER CULTURE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN ASSEMBLY; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ANIMALS; ANTIGENS, CD; CADHERINS; CAPILLARY PERMEABILITY; CELL ADHESION; CELLS, CULTURED; CORONARY VESSELS; CYCLIC GMP; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; GUANYLATE CYCLASE; INSULIN; MALE; MICROVESSELS; MYOSIN LIGHT CHAINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; RATS; RATS, WISTAR; RECEPTOR, INSULIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77952888161     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.203901     Document Type: Article

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