The effect of reduction of propellant mass fraction on the injection profile of metered dose inhalers

International Journal of Pharmaceutics

Volumn 391, Issue 1-2, 2010, Pages 221-229

  Ju, Dehao ^a   Shrimpton, John ^a   Hearn, Alex ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b Kind Consumer Limited   (United Kingdom)

Author keywords

Atomization; Flash evaporation; Model; Multiphase

Indexed keywords

FLUORINATED HYDROCARBON; PROPELLANT;

AEROSOL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FLOW KINETICS; FLOW RATE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; METERED DOSE INHALER; NEBULIZATION; PREDICTION; PRIORITY JOURNAL; SIMULATION; VALIDATION PROCESS;

AEROSOL PROPELLANTS; AEROSOLS; CHEMISTRY, PHARMACEUTICAL; HYDROCARBONS, FLUORINATED; METERED DOSE INHALERS; MODELS, STATISTICAL; PARTICLE SIZE; PRESSURE; RHEOLOGY;

EID: 77952884752     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.03.003     Document Type: Article

References (22)

1. Aamir M.A., Watkins A.P. Numerical analysis of depressurisation of highly pressurised liquid propane. Int. J. Heat Fluid Flow 2000, 21:420-431.
2. Albrecht H.E. Laser Doppler and Phase Doppler Measurement Techniques 2003, Springer, Berlin.
3. Atkins P.W., De Paula J. Atkins' Physical Chemistry 2006, Oxford University Press.
4. Clark, A.R., 1991. Metered atomization for respiratory drug delivery. Ph.D. Thesis, Loughborough University of Technology.
5. Dyakowski T., Williams R.A. Measurement of particle velocity distribution in a vertical channel. Powder Technol. 1993, 77:135-142.
6. Dunbar C.A., 1996. An experimental and the theoretical investigation of the spray issued from a pressurized metered-dose inhaler. Ph.D. Thesis, Institute of Science and Technology, University of Manchester.
7. Farkas A., Balashazy I., Szocs K. Characterization of regional and local deposition of inhaled aerosol drugs in the respiratory system by computational fluid and particle dynamics methods. J. Aerosol Med. 2006, 19:329-343.
8. Finlay W. The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction 2002, Academic Press, San Diego.
9. Fujiwara K., Nakamura S., Noguchi M. Thermodynamic properties for R-404A. Int. J. Thermophys. 1999, 20:129-140.
10. ® soft Mist inhaler and pressurized metered dose inhalers. J. Aerosol Med. 2005, 18:273-282.
11. Jin H.H., Fan J.R., Zeng M.J., Cen K.F. Large eddy simulation of inhaled particle deposition within the human upper respiratory tract. J. Aerosol Sci. 2007, 38:257-268.
12. Kleinstreuer C., Shi H.W., Zhang Z. Computational analyses of a pressurized metered dose inhaler and a new drug aerosol targeting methodology. J. Aerosol Med. 2007, 20:294-309.
13. Lide, David R. CRC Handbook of Chemistry and Physics 2002, 83rd edition.
14. Newman Stephen P. Principle of metered-dose inhaler design. Respir. Care 2005, 50:1177-1190.
15. Perry R.H., Green D.W. Perry's Chemical Engineers' Handbook 1997, 7th edition.
16. Potter M.C., Wiggert David C. Mechanics of Fluids 1997, Pretice-Hall, Inc. 2nd edition.
17. Ray E.D., George L.T. Handbook of Tables for Applied Engineering Science 1973, CRC Press.
18. Solomon A.S.P., Rupprecht S.D., Chen L.D., Faeth G.M. Flow and atomization in flashing injectors. Atomisation Spray Technol. 1985, 1:53-76.
19. Takano H., Nishida N., Itoh M., Hyo N., Majima Y. Inhaled particle deposition in unsteady-state respiratory flow at a numerically constructed model of the human larynx. J. Aerosol Med. 2006, 19:314-328.
20. Touloukian Y.S., Makita T. Specific heat: nonmetallic liquids and gases. Thermophys. Properties Matter 1970, 6.
21. Wallis G.B. One-dimensional Two-phase Flow 1969, McGraw-Hill, Inc., New York.
22. Swarbrick J. 3rd edition. Encyclopedia of Pharmaceutical Technology 2007, 4. Informa Healthcare USA, Inc.