Cannabinoids inhibit cellular respiration of human oral cancer cells

Pharmacology

Volumn 85, Issue 6, 2010, Pages 328-335

  Whyte, Donna A ^a   Al Hammadi, Suleiman ^c   Balhaj, Ghazala ^c   Brown, Oliver M ^a   Penefsky, Harvey S ^b   Souid, Abdul Kader ^c  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^c UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Cannabinoids; Mitochondria; Oral cancer; Respiration

Indexed keywords

ANANDAMIDE; CAMPTOTHECIN; CARBOPLATIN; CISPLATIN; DELTA8 TETRAHYDROCANNABINOL; DOXORUBICIN; DRONABINOL; OXALIPLATIN; PROTEIN BCL 2; ADENOSINE TRIPHOSPHATE; DELTA-8-TETRAHYDROCANNABINOL;

ARTICLE; CANCER CELL; CELL RESPIRATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MOUTH CANCER; OXYGEN CONSUMPTION; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; DRUG EFFECTS; METABOLISM; MITOCHONDRION; MOUTH TUMOR; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; CELL LINE, TUMOR; CELL RESPIRATION; HUMANS; MITOCHONDRIA; MOUTH NEOPLASMS; OXYGEN CONSUMPTION; TETRAHYDROCANNABINOL; DRONABINOL;

EID: 77952867838     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000312686     Document Type: Article

References (23)

1. Gaoni Y, Mechoulam R: Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964; 86: 1646-1647.
2. 9-tetrahydrocannabinol: effects on cultured human leucocytes. J Clin Pharmacol New Drugs 1970; 10: 228-230.
3. 9- Tetrahydrocannabinol- induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. J Pharmacol Exp Ther 2002; 302: 451-465.
4. Baek SH, Kim YO, Kwag JS, Choi KE, Jung WY, Han DS: Boron trifluoride etherate on silica-A modified Lewis acid reagents (VII): antitumor activity of cannabigerol against human oral epitheloid carcinoma cells. Arch Pharm Res 1998; 21: 353-356.
5. Sarfaraz S, Adhami VM, Syed DN, Afaq F, Mukhtar H: Cannabinoids for cancer treatment: progress and promise. Cancer Res 2008; 68: 339-342.
6. Bifulco M, Laezza C, Pisanti S, Gazzerro P: Cannbinoids and cancer: pros and cons of an antitumor strategy. Br J Pharmacol 2006; 148: 123-135.
7. Kogan NM: Cannbinoids and cancer. Mini Rev Med Chem 2005; 5: 941-952.
8. 9-Tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involvement of Bcl-2 and caspase-1. J Pharmacol Experimental Therapeutics 1998; 286: 1103-1109.
9. Batandier C, Leverve X, Fontainer E: Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I. J Biol Chem 2004; 279: 17197-17204.
10. 9- Tetrahydrocannabinol disrupts mitochondrial function and cell energetics. Am J Physiol Lung Cell Mol Physiol 2003; 284:L298-L306.
11. Sacks PG, Parnes SM, Gallick GE, Mansouri Z, Lichtner R, Satya-Prakash KL, Pathak S, Parsons DF: Establishment and characterization of two new squamous cell carcinoma cell lines derived from tumors of the head and neck. Cancer Res 1988; 15: 2858-2866.
12. Gibson S, Shillitoe E: Analysis of apoptosisassociated genes and pathways in oral cancer cells. J Oral Pathol Med 2006; 35: 146-154.
13. Gibson S, Pellenz C, Hutchinson RE, Davey FR, Shillitoe EJ: Induction of apoptosis in oral cancer cells by an anti-bcl-2 ribozyme delivered by an adenovirus vector. Clin Cancer Res 2000; 6: 213-222.
14. Yao L, Iwai M, Furata I: Correlations of bcl-2 and p53 expression with the clinicopathological features in tongue squamous cell carcinomas. Oral Oncol 1999; 35: 56-62.
15. Whyte DA, Broton CE, Shillitoe EJ: The unexplained survival of cells in oral cancer: what is the role of p53? J Oral Pathol Med 2002; 31: 125-133.
16. Tao Z, Withers HG, Penefsky HS, Goodisman J, Souid AK: Inhibition of cellular respiration by doxorubicin. Chem Res Toxicol 2006; 19: 1051-1058.
17. 9-tetrahydrocannabinol on mitochondrial processes. Biochem Pharmacol 1972; 21: 1217-1226.
18. Beyer RE: Preparation, properties, and conditions for assay of phosphorylating electron transport particles (ETPH) and its variations. Methods Enzymol 1967; 10: 186-194.
19. 9-tetrahydrocannabinol as an inhibitor of sodium- and potassiumdependent adenosine triphosphatase. Mol Pharmacol 1978; 14: 130-137.
20. World Health Organization: The World Oral Health Report 2003. Geneva, World Health Organization, 2003, pp 6-7.
21. Centers for Disease Control and Prevention: Preventing and controlling oral and pha ryngeal cancer: recommendations from a national strategic planning conference. MMWR 1998; 47: 1-12.
22. Munson AE, Harris LS, Friedman MA, Dewey WL, Carchman RA: Antineoplastic activity of cannabinoids. J Natl Cancer Inst 1975; 55: 597-602.
23. Casanova ML, Blazquez C, Martinez-Palacio J, Villanueva C, Fernandez-Acenero MJ, Huffman JW, Jorcano JL, Guzman M: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 2003; 111: 43-50.