메뉴 건너뛰기




Volumn , Issue , 2009, Pages 389-401

Role of CagA in helicobacter pylori infection and pathology

Author keywords

[No Author keywords available]

Indexed keywords


EID: 77952832167     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-69182-4_15     Document Type: Chapter
Times cited : (1)

References (47)
  • 1
    • 0027531954 scopus 로고
    • A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains
    • Ahmad, S., Banville, D., Zhao, Z., et al. 1993. A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc Natl Acad Sci USA 90:2197-2201.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2197-2201
    • Ahmad, S.1    Banville, D.2    Zhao, Z.3
  • 2
    • 0038780624 scopus 로고    scopus 로고
    • Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA
    • Amieva, M.R., Vogelmann, R., Covacci, A., et al. 2003. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science 300:1430-1434.
    • (2003) Science , vol.300 , pp. 1430-1434
    • Amieva, M.R.1    Vogelmann, R.2    Covacci, A.3
  • 3
    • 0034695875 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells
    • Asahi, M., Azuma, T., Ito, S., et al. 2000. Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med 191:593-602.
    • (2000) J Exp Med , vol.191 , pp. 593-602
    • Asahi, M.1    Azuma, T.2    Ito, S.3
  • 4
    • 0036891391 scopus 로고    scopus 로고
    • Correlation between variation of the 3'region of the cagA gene in Helicobacter pylori and disease outcome in Japan
    • Azuma, T., Yamakawa, A., Yamazaki, S., et al. 2002. Correlation between variation of the 3'region of the cagA gene in Helicobacter pylori and disease outcome in Japan. J Infect Dis 186:1621-1630.
    • (2002) J Infect Dis , vol.186 , pp. 1621-1630
    • Azuma, T.1    Yamakawa, A.2    Yamazaki, S.3
  • 5
    • 12144291018 scopus 로고    scopus 로고
    • Variation in the SHP-2 binding site of Helicobacter pylori CagA protein is associated with gastric atrophy and cancer
    • Azuma, T., Yamazaki, S., Yamakawa, A., et al. 2004. Variation in the SHP-2 binding site of Helicobacter pylori CagA protein is associated with gastric atrophy and cancer. J Infect Dis 189:820-827.
    • (2004) J Infect Dis , vol.189 , pp. 820-827
    • Azuma, T.1    Yamazaki, S.2    Yamakawa, A.3
  • 6
    • 0035162820 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells
    • Backert, S., Moese, S., Selbach, M., et al. 2001. Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells. Mol Microbiol 42:631-644.
    • (2001) Mol Microbiol , vol.42 , pp. 631-644
    • Backert, S.1    Moese, S.2    Selbach, M.3
  • 7
    • 28044437976 scopus 로고    scopus 로고
    • Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells
    • Bagnoli, F., Buti, L., Tompkins, L., et al. 2005. Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells. Proc Natl Acad Sci USA 102:16339-16344.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16339-16344
    • Bagnoli, F.1    Buti, L.2    Tompkins, L.3
  • 8
    • 0029043658 scopus 로고
    • Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
    • Blaser, M.J., Perez-Perez, G.I., Kleanthous, H., et al. 1995. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 55:2111-2115.
    • (1995) Cancer Res , vol.55 , pp. 2111-2115
    • Blaser, M.J.1    Perez-Perez, G.I.2    Kleanthous, H.3
  • 9
    • 0029963677 scopus 로고    scopus 로고
    • Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-Associated virulence factors
    • Censini, S., Lange, C., Xiang, Z., et al. 1996. Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-Associated virulence factors. Proc Natl Acad Sci USA 93:14648-14653.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14648-14653
    • Censini, S.1    Lange, C.2    Xiang, Z.3
  • 10
    • 0037732638 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
    • Churin, Y., Al-Ghoul, L., Kepp, O., et al. 2003. Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol 161:249-255.
    • (2003) J Cell Biol , vol.161 , pp. 249-255
    • Churin, Y.1    Al-Ghoul, L.2    Kepp, O.3
  • 11
    • 0023690989 scopus 로고
    • A human model of gastric carcinogenesis
    • Correa, P. 1988. A human model of gastric carcinogenesis. Cancer Res 48:3554-3560.
    • (1988) Cancer Res , vol.48 , pp. 3554-3560
    • Correa, P.1
  • 12
    • 0027173990 scopus 로고
    • Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer
    • Covacci, A., Censini, S., Bugnoli, M., et al. 1993. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 90:5791-5795.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5791-5795
    • Covacci, A.1    Censini, S.2    Bugnoli, M.3
  • 13
    • 0033591290 scopus 로고    scopus 로고
    • Helicobacter pylori virulence and genetic geography
    • Covacci, A., Telford, J.L., Del Giudice, G., et al. 1999. Helicobacter pylori virulence and genetic geography. Science 284:1328-1333.
    • (1999) Science , vol.284 , pp. 1328-1333
    • Covacci, A.1    Telford, J.L.2    Del Giudice, G.3
  • 14
    • 0037162397 scopus 로고    scopus 로고
    • SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities
    • De Souza, D., Fabri, L.J., Nash, A., et al. 2002. SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry 41:9229-9236.
    • (2002) Biochemistry , vol.41 , pp. 9229-9236
    • De Souza, D.1    Fabri, L.J.2    Nash, A.3
  • 15
    • 0027176157 scopus 로고
    • An association between Helicobacter pylori infection and gastric cancer
    • The Eurogast Study Group
    • The Eurogast Study Group. 1993. An association between Helicobacter pylori infection and gastric cancer. Lancet 341:1359-1362.
    • (1993) Lancet , vol.341 , pp. 1359-1362
  • 16
    • 0027531637 scopus 로고
    • SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases
    • Feng, G.S., Hui, C.C., Pawson, T. 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607-1611.
    • (1993) Science , vol.259 , pp. 1607-1611
    • Feng, G.S.1    Hui, C.C.2    Pawson, T.3
  • 17
    • 0026471539 scopus 로고
    • Identification of a human src homology 2-containing protein-tyrosine- phosphatase: A putative homolog of Drosophila corkscrew
    • Freeman, R.M., Jr., Plutzky, J., Neel, B.G. 1992. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc Natl Acad Sci USA 89:11239-11243.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11239-11243
    • Freeman Jr., R.M.1    Plutzky, J.2    Neel, B.G.3
  • 18
    • 0037195107 scopus 로고    scopus 로고
    • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
    • Higashi, H., Tsutsumi, R., Fujita, A., et al. 2002a. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci USA 99:14428-14433.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14428-14433
    • Higashi, H.1    Tsutsumi, R.2    Fujita, A.3
  • 19
    • 0037169076 scopus 로고    scopus 로고
    • SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    • Higashi, H., Tsutsumi, R., Muto, S., et al. 2002b. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295:683-686.
    • (2002) Science , vol.295 , pp. 683-686
    • Higashi, H.1    Tsutsumi, R.2    Muto, S.3
  • 20
    • 0344197110 scopus 로고    scopus 로고
    • Meta-Analysis of the relationship between cagA seropositivity and gastric cancer
    • Huang, J.Q., Zheng, G.F., Sumanac, K., et al. 2003. Meta-Analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 125:1636-1644.
    • (2003) Gastroenterology , vol.125 , pp. 1636-1644
    • Huang, J.Q.1    Zheng, G.F.2    Sumanac, K.3
  • 22
    • 0030919631 scopus 로고    scopus 로고
    • Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan
    • Ito, Y., Azuma, T., Ito, S., et al. 1997. Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan. J Clin Microbiol 35:1710-1714.
    • (1997) J Clin Microbiol , vol.35 , pp. 1710-1714
    • Ito, Y.1    Azuma, T.2    Ito, S.3
  • 23
    • 8044223422 scopus 로고    scopus 로고
    • Profile of Helicobacter pylori cytotoxin derived from two areas of Japan with different prevalence of atrophic gastritis
    • Ito, S., Azuma, T., Murakita, H., et al. 1996. Profile of Helicobacter pylori cytotoxin derived from two areas of Japan with different prevalence of atrophic gastritis. Gut 39:800-806.
    • (1996) Gut , vol.39 , pp. 800-806
    • Ito, S.1    Azuma, T.2    Murakita, H.3
  • 24
    • 35348979761 scopus 로고    scopus 로고
    • Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression
    • Jackson, C.B., Judd, L.M., Menheniott, T.R., et al. 2007. Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression. J Pathol 213:140-151.
    • (2007) J Pathol , vol.213 , pp. 140-151
    • Jackson, C.B.1    Judd, L.M.2    Menheniott, T.R.3
  • 25
    • 0029019917 scopus 로고
    • Serum anti-Helicobacter pylori antibody and gastric carcinoma among young adults Research group on prevention of gastric carcinoma among young adults
    • Kikuchi, S., Wada, O., Nakajima, T., et al. 1995. Serum anti-Helicobacter pylori antibody and gastric carcinoma among young adults. Research group on prevention of gastric carcinoma among young adults. Cancer 75:2789-2793.
    • (1995) Cancer , vol.75 , pp. 2789-2793
    • Kikuchi, S.1    Wada, O.2    Nakajima, T.3
  • 26
    • 0033845178 scopus 로고    scopus 로고
    • Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering
    • Kodama, A., Matozaki, T., Fukuhara, A., et al. 2000. Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering. Mol Biol Cell 11:2565-2575.
    • (2000) Mol Biol Cell , vol.11 , pp. 2565-2575
    • Kodama, A.1    Matozaki, T.2    Fukuhara, A.3
  • 27
    • 0036809776 scopus 로고    scopus 로고
    • Grb2 is a key mediator of Helicobacter pylori CagA protein activities
    • Mimuro, H., Suzuki, T., Tanaka, J., et al. 2002. Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol Cell 10:745-755.
    • (2002) Mol Cell , vol.10 , pp. 745-755
    • Mimuro, H.1    Suzuki, T.2    Tanaka, J.3
  • 28
    • 34447519946 scopus 로고    scopus 로고
    • Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells
    • Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., et al. 2007. Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene 26:4617-4626.
    • (2007) Oncogene , vol.26 , pp. 4617-4626
    • Murata-Kamiya, N.1    Kurashima, Y.2    Teishikata, Y.3
  • 29
    • 0038771965 scopus 로고    scopus 로고
    • TheShp ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
    • Neel, B.G., Gu, H., Pao, L. 2003. The Shping news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci 28:284-293.
    • (2003) Trends Biochem Sci , vol.28 , pp. 284-293
    • Neel, B.G.1    Gu, H.2    Pao, L.3
  • 30
    • 17344379177 scopus 로고    scopus 로고
    • Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion
    • Odenbreit, S., Puls, J., Sedlmaier, B., et al. 2000. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287:1497-1500.
    • (2000) Science , vol.287 , pp. 1497-1500
    • Odenbreit, S.1    Puls, J.2    Sedlmaier, B.3
  • 31
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000. The global picture
    • Parkin, D.M., Bray, F.I., Devesa, S.S. 2001. Cancer burden in the year 2000. The global picture. Eur J Cancer 37:S4-S66.
    • (2001) Eur J Cancer , vol.37
    • Parkin, D.M.1    Bray, F.I.2    Devesa, S.S.3
  • 32
    • 0025945933 scopus 로고
    • Helicobacter pylori infection and the risk of gastric carcinoma
    • Parsonnet, J., Friedman, G.D., Vandersteen, D.P., et al. 1991. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325:11127-11131.
    • (1991) N Engl J Med , vol.325 , pp. 11127-11131
    • Parsonnet, J.1    Friedman, G.D.2    Vandersteen, D.P.3
  • 33
    • 0033848878 scopus 로고    scopus 로고
    • Integrating the MAP kinase signal into the G1 phase cell cycle machinery
    • Roovers, K., Assoian, R.K. 2000. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 22:818-826.
    • (2000) Bioessays , vol.22 , pp. 818-826
    • Roovers, K.1    Assoian, R.K.2
  • 34
    • 34249090814 scopus 로고    scopus 로고
    • Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity
    • Saadat, I., Higashi, H., Obuse, C., et al. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 447:330-333.
    • Nature , vol.447 , pp. 330-333
    • Saadat, I.1    Higashi, H.2    Obuse, C.3
  • 35
    • 33747887088 scopus 로고    scopus 로고
    • Relationship between the diversity of the cagA gene of Helicobacter pylori and gastric cancer in Okinawa, Japan
    • Satomi, S., Yamakawa, A., Matsunaga, S., et al. 2006. Relationship between the diversity of the cagA gene of Helicobacter pylori and gastric cancer in Okinawa, Japan. J Gastroenterol 41:668-673.
    • (2006) J Gastroenterol , vol.41 , pp. 668-673
    • Satomi, S.1    Yamakawa, A.2    Matsunaga, S.3
  • 36
    • 0033456273 scopus 로고    scopus 로고
    • Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori
    • Segal, E.D., Cha, J., Lo, J., et al. 1999. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci USA 96:14559-14564.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14559-14564
    • Segal, E.D.1    Cha, J.2    Lo, J.3
  • 37
    • 0030034805 scopus 로고    scopus 로고
    • Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell protein
    • Segal, E.D., Falkow, S., Tompkins, L.S. 1996. Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell protein. Proc Natl Acad Sci USA 93:1259-1264.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1259-1264
    • Segal, E.D.1    Falkow, S.2    Tompkins, L.S.3
  • 38
    • 0036510363 scopus 로고    scopus 로고
    • Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    • Selbach, M., Moese, S., Hauck, C.R., et al. 2002. Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem 277:6775-6778.
    • (2002) J Biol Chem , vol.277 , pp. 6775-6778
    • Selbach, M.1    Moese, S.2    Hauck, C.R.3
  • 39
    • 0036227053 scopus 로고    scopus 로고
    • C-Src/Lyn kinase activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs
    • Stein, M., Bagnoli, F., Halenbeck, R., et al. 2002. c-Src/Lyn kinase activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol 43:971-980.
    • (2002) Mol Microbiol , vol.43 , pp. 971-980
    • Stein, M.1    Bagnoli, F.2    Halenbeck, R.3
  • 40
    • 0033953359 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation
    • Stein, M., Rappuoli, R., Covacci, A. 2000. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci USA 97:1263-1268.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1263-1268
    • Stein, M.1    Rappuoli, R.2    Covacci, A.3
  • 41
    • 27744471043 scopus 로고    scopus 로고
    • Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion
    • Suzuki, M., Mimuro, H., Suzuki, T., et al. 2005. Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J Exp Med 202:1235-1247.
    • (2005) J Exp Med , vol.202 , pp. 1235-1247
    • Suzuki, M.1    Mimuro, H.2    Suzuki, T.3
  • 42
    • 0030835739 scopus 로고    scopus 로고
    • The complete genome sequence of the gastric pathogen Helicobacter pylori
    • Tomb, J.F., White, O., Kerlavage, A.R., et al. 1997. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388:539-547.
    • (1997) Nature , vol.388 , pp. 539-547
    • Tomb, J.F.1    White, O.2    Kerlavage, A.R.3
  • 43
    • 33645214468 scopus 로고    scopus 로고
    • FAK is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA
    • Tsutsumi, R., Takahashi, A., Azuma, T., et al. 2006. FAK is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. Mol Cell Biol 26:261-276.
    • (2006) Mol Cell Biol , vol.26 , pp. 261-276
    • Tsutsumi, R.1    Takahashi, A.2    Azuma, T.3
  • 44
    • 0033001144 scopus 로고    scopus 로고
    • Geographic distribution of vacA allelic types of Helicobacter pylori
    • van Doorn, L.J., Figueiredo, C., Megraud, F., et al. 1999. Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology 116:823-830.
    • (1999) Gastroenterology , vol.116 , pp. 823-830
    • Van Doorn, L.J.1    Figueiredo, C.2    Megraud, F.3
  • 45
    • 0032815340 scopus 로고    scopus 로고
    • Relationship between the cagA 3' repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH
    • Yamaoka, Y., El-Zimaity, H.M., Gutierrez, O., et al. 1999. Relationship between the cagA 3' repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH Gastroenterology 117:342-349.
    • (1999) Gastroenterology , vol.117 , pp. 342-349
    • Yamaoka, Y.1    El-Zimaity, H.M.2    Gutierrez, O.3
  • 46
    • 0031878592 scopus 로고    scopus 로고
    • Variants of the 3' region of the cagA gene in Helicobacter pylori isolates from patients with different H pylori-Associated diseases
    • Yamaoka, Y., Kodama, T., Kashima, K., et al. 1998. Variants of the 3' region of the cagA gene in Helicobacter pylori isolates from patients with different H pylori-Associated diseases. J Clin Microbiol 36:2258-2263.
    • (1998) J Clin Microbiol , vol.36 , pp. 2258-2263
    • Yamaoka, Y.1    Kodama, T.2    Kashima, K.3
  • 47
    • 0037439278 scopus 로고    scopus 로고
    • The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa
    • Yamazaki, S., Yamakawa, A., Ito, Y., et al. 2003. The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa. J Infect Dis 187:334-337
    • (2003) J Infect Dis , vol.187 , pp. 334-337
    • Yamazaki, S.1    Yamakawa, A.2    Ito, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.