KSHV downregulation of galectin-3 in Kaposi's sarcoma

Glycobiology

Volumn 20, Issue 5, 2009, Pages 521-532

  Alcendor, Donald J ^a   Knobel, Susan M ^a   Desai, Prashant ^b   Zhu, Wen Q ^a   Vigil, Hollie E ^a   Hayward, Gary S ^b  

^a MEHARRY MEDICAL COLLEGE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Endothelial cells; Galectin 3; Immunohistochemistry; Kaposi's sarcoma; Transcriptional suppression

Indexed keywords

FLICE INHIBITORY PROTEIN; GALECTIN; GALECTIN 1; GALECTIN 2; GALECTIN 3; GALECTIN 4; GALECTIN 5; GALECTIN 6; GALECTIN 7; LATENCY ASSOCIATED NUCLEAR ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CELL LABELING; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; HELA CELL; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPOSI SARCOMA; MAJOR CLINICAL STUDY; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN BLOOD VESSEL; SPINDLE CELL; TISSUE MICROARRAY; VASCULAR ENDOTHELIUM;

ANTIGENS, VIRAL; DOWN-REGULATION; ENDOTHELIAL CELLS; GALECTIN 3; HELA CELLS; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; MICROCIRCULATION; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOMA, KAPOSI; TISSUE ARRAY ANALYSIS; TUMOR CELLS, CULTURED;

HUMAN HERPESVIRUS 8;

EID: 77952822155     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwp204     Document Type: Article

References (71)

1. Alkan S, Karcher DS, Ortiz A, Khalil S, Akhtar M, Ali MA. 1997. Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus in organ transplant patients with immunosuppression. Br. J. Haematol. 96:412-414.
2. Barondes SH, Castronovo V, Cooper DNW, Cummings RD, Drickamer K, Feizi T, Gitt MA, Hirabaysahi J, Hughes C, Kasai K, et al. 1994. Galectins: A family of animal beta-galactoside-binding lectins. Cell 76:597-598.
3. Barondes SH, Cooper DN, Gitt MA, Leffler H. 1994b. Galectins. Structure and function of a large family of animal lectins. J. Biol. Chem. 269:20807-20810.
4. Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, Wang GH, Senkevich TG, Alnemri ES, Moss B, et al. 1997. Death effector domaincontaining herpesvirus and poxvirus proteins inhibit both Fas-and TNFR1induced apoptosis. Proc Natl. Acad Sci USA 4:1172-1176.
5. Boshoff C, Schulz TF, Kennedy M M, Graham A K, Fisher C, Thomas A, McGee JO, Weiss RA, O'Leary JJ. 1995. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat. Med. 1:1274-1278.
6. Bresalier RS, Yan PS, Byrd JC, Lotan R, Raz A. 1997. Expression of the endogenous galactose-binding protein galectin-3 correlates with the malignant potential of tumors in the central nervous system. Cancer 4:776-787.
7. Califice S, Castronovo V, Bracke M, van den Brule F. 2004. Dual activities of galectin-3 in human prostate cancer: Tumor suppression of nuclear galectin-3 vs. tumor promotion of cytoplasmic galectin-3. Oncogene 23: 7527-36.
8. Castronovo V, Campo E, van den Brule FA, Claysmith AP, Cioce V, Liu FT, Fernandez PL, Sobel ME. 1992. Inverse modulation of steady-state messenger RNA levels of two non-integrin laminin-binding proteins in human colon carcinoma. J. Natl. Cancer Inst. 15:1161-1169.
9. Castronovo V, Van Den Brule FA, Jackers P, Clausse N, Liu FT, Gillet C, Sobel ME. 1996. Decreased expression of galectin-3 is associated with progression of human breast cancer. J. Pathol. 179:43-48.
10. Cesarman E, Chang Y, Moore P, Said JW, Knowles DM. 1995. Kaposi's sarcomaassociated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. Med. 18:1186-1191.
11. Cesarman E, Knowles DM. 1997. Kaposi's sarcoma-associated herpesvirus: A lymphotropic human herpesvirus associated with Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Semin Diagn Pathol. 14:54-66.
12. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS. 1994. Identication of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865-1869.
13. Chaudhary PM, Jasmin A, Eby MT, Hood L. 1999. Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins. Oncogene 42:5738-5746.
14. Ciufo DM, Cannon JS, Poole LJ, Wu FY, Murray P, Ambinder RF, Hayward GS. 2001. Spindle cell conversion by Kaposi's sarcoma-associated herpesvirus: Formation of colonies and plaques with mixed lytic and latent gene expression in infected primary dermal microvascular endothelial cell cultures. J. Virol. 75:5614-5626.
15. Chiou CJ, DM Poole LJ, Kim PS, Ciufo DM, Cannon JS, ap Rhys CM, Alcendor DJ, Zong JC, Ambinder RF, Hayward GS. 2002. Patterns of gene expression and a transactivation function exhibited by the vGCR (ORF74) chemokine receptor protein of Kaposi's sarcoma-associated herpesvirus. J. Virol. 76:3421-3439.
16. Coscoy L, Ganem D. 2001. A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation. J. Clin. Invest. 107:1599-1606.
17. Dagher SF, Wang JL, Patterson RJ. 1995. Identication of galectin-3 as a factor in pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 92:1213-1217.
18. Danguy A, Camby I, Kiss R. 2002. Galectins and cancer. Biochim. Biophys. Acta. 1572:285-293.
19. Davidson PJ, Davis MJ, Patterson RJ, Ripoche MA, Poirier F, Wang JL. 2002. Shuttling of galectin-3 between the nucleus and cytoplasm. Glycobiology 12:329-37.
20. Di Bartolo DL, Cannon M, Lui YF, Renne R, Chadburn A, Boshoff, Cesarman E. 2008. KSHV LANA inhibits TGF-beta signaling through epi-genetic silencing of the TGF-beta type II receptor. Blood 9:4731-4740.
21. Dodd RB, Allen MD, Brown SE, Sanderson CM, Duncan LM, Lehner PJ, Bycroft M, Read RJ. 2004. Solution structure of the Kaposi's sarcomaassociated herpesvirus K3 N-terminal domain reveals a novel E2-binding C4HC3-type RING domain. J Biol Chem. 279:53840-53847.
22. Dumic J, Dabelic S, Flogel M. 2006. Galectin-3: An open-ended story. Biochim Biophys Acta. 4:616-635.
23. Fernandez PL, Merino MJ, Gomez M, Campo E, Medina T, Castronovo V, Sanjuan X, Cardesa A, Liu FT, Sobel ME. 1997. Galectin-3 and laminin expression in neoplastic and non-neoplastic thyroid tissue. Am. J. Pathol. 1:80-86.
24. Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M. 2003. KSHV vFLIP binds to IKK-gamma to activate IKK. J. Cell Sci. Pt 18: 3721-3728.
25. Friborg J Jr, Kong W, Hottiger MO, Nabel GJ. 1999. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 6764:889-894.
26. Fujimuro M, Wu FY, ApRhys C, Kajumbula H, Young DB, Hayward GS, Hayward SD. 2003. A novel viral mechanism for dyregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat. Med. 3:300-306.
27. Grossmann C, Podgrabinska S, Skobe M, Ganem D. 2006. Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype. J. Virol. 14:7179-7185.
28. Guasparri I, Keller SA, Cesarman E. 2004. KSHV vFLIP is essential for the survival of infected lymphoma cells. JEM 199:993-1003.
29. Hayward GS. 2003. Initiation of angiogenic Kaposi's sarcoma lesions. Cancer Cell 3:1-3.
30. Hirabayashi J, Kasai K. 1993. The family of metazoan metal-independent betagalactoside-binding lectins: Structure, function and molecular evolution. Glycobiology. 3:297-304.
31. Honjo Y, Inohora H, Akahani S, Yoshi J, Hattori K, Tomiyama Y, Raz A, Kubo T. 2000. Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma. Clin. Cancer Res. 12:4635-4640.
32. Horenstein MG, Cesarman E, Wang X, Linkov I, Prieto VG, Louie DC. 1997. Cyclin D1 and retinoblastoma protein expression in Kaposi's sarcoma. J. Cutan. Pathol. 10:585-589.
33. Hsu D K, Yang R Y, Pan Z X, Yu L, Salomon DR, Fung-Leung WP, Liu F T. 2000. Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses. Am. J. Pathol. 156:1073-1083.
34. Hsu DK, Dowling CA, Jeng KC, Chen JT, Yang RY, Liu FT. 1999. Galectin-3 expression in induced in cirrhotic liver and hepatocellular carcinoma. Int. J. Cancer 4:519-526.
35. Hughes RC. 2001. Galectins as modulators of cell adhesion. Biochimie. 83: 667-676.
36. Inohara H, Akahani S, Raz A. 1998. Galectin-3 stimulates cell proliferation. Exp. Cell. Res. 245:294-302.
37. Irimura T, Matsushita Y, Sutton RC, Carralero D, Ohannesian DW, Cleary KR, Ota DM, Nicolson GL, Lotan R. 1991. Increased content of endogenous lactose-binding lectin in human colorectal carcinoma progresses to metastatic stages. Cancer Res. 1:387-393.
38. Ishido S, Wang C, Lee BS, Cohen GB, Jung JU. 2000. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcomaassociated herpesvirus K3 and K5 proteins. J. Virol. 74:5300-5309.
39. Jenner RG, Boshoff C. 2002. The molecular pathology of Kaposi's sarcomaassociated herpesvirus. Biochim. Biophys. Acta. 1602:1-22.
40. Johnson KD, Glinskii OV, Mossine VV, Turk JR, Mawhinney TP, Anthony DC, Henry CJ, Huxley VH, Glinsky GV, Pienta KJ, et al. 2007. Galectin-3 as a potential therapeutic target in tumors arising from malignant endothelia. Neoplasia. 8:662-670.
41. Junking M, Wongkham C, Sripa B, Sawanyawisuth K, Araki N, Wongkham S. 2008. Decreased expression of galectin-3 is associated with metastatic potential of liver fluke-associated cholangiocarcinoma. Eur. J. Cancer. 44: 619-626.
42. Lagunoff M, Bechtel J, Venetsanakos E, Roy A M, Abbey N, Herndier B, McMahon M, Ganem D. 2002. De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. J. Virol. 76:2440-2448.
43. Li Q, Means R, Lang S, Jung JU. 2006. Downregulation of interferon gamma receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5. J. Virol. 5:2117-2127.
44. Liu C, Okruzhnov Y, Li H, Nicholas J. 2001. Human herpesvirus 8 (HHV-8)encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effts. J. Virol. 75:10933-10940.
45. Liu L, Eby MT, Rathore N, Sinha SK, Kumar A, Chaudhary PM. 2002. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J. Biol. Chem. 16:p. 13745-13751.
46. Lotan R, Belloni PN, Tressler RJ, Lotan D, Xu XC, Nicolson GL. 1994. Expression of galectins on microvessel cells and their involvement in tumor cell adhesion. Glycoconj. J. 5:462-468.
47. Lotz MM, Andrews CW Jr, Korzelius CA, Lee EC, Steele GDJr, Clarke A, Mercurio AM. 1993. Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. Proc. Natl. Acad. Sci. USA 8:3466-3470.
48. Lui L, Sakai T, Sano N, Fukui K. 2004. Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear with nuclear factor kappa B signaling. Biochem. J. 380:31-41.
49. Mansouri M, Douglas J, Rose PP, Gouveia K, Thomas G, Means RE, Moses AV, Fruh K. 2006. Kaposi's sarcoma herpesvirus K5 eliminates CD31/PECAM from endothelial cells. Blood. 108:1932-1940.
50. Mbulaiteye SM, Engels EA. 2006. Kaposi's sarcoma risk among transplant recipients in the United States (1993-2003). Int. J. Cancer. 119:2685-91.
51. Means RE, Ishido S, Alvarez X, Jung JU. 2002. Multiple endocytic trafficking pathways of MHC class I molecules induced by a Herpesvirus protein. EMBO J. 21:1638-1649.
52. Mollenhauer J., Deichmann M, Helmke B, Muller H, Kollender G, Holmskov U, Ligtenberg T, Krebs I, Wiemann S, Bantel-Schaal U, et al. 2003. Frequent downregulation of DMBT1 in epithelial skin cancer. Int. J. Cancer. 2:149-157.
53. Moore PS, Chang Y. 1998. Kaposi's sarcoma (KS) KS-associated herpesvirus and the criteria for causality in the age of molecular biology. Am. J. Epidemiol. 8:217-221.
54. Moore PS, Chang Y. 2002. Kaposi's sarcoma associated herpesvirus. Knipe D M and Howley P M, editors. Field's Virology. Philadelphia, PA: Lippincott Williams and Wilkins. p. 2803-2833.
55. Moutsatsos IK, Davis JM, Wang JL. 1986. Endogenous lectins from cultured cells: Subcellular localization of carbohydrate-binding protein 35 in 3T3 fibroblasts. J. Cell Biol. 102:477-483.
56. Ojala PM, Yamamoto K, Castanos-Velez E, Biberfeld P, Korsmeyer SJ, Makela TP. 2000. The apoptotic v-cyclin-CDk6 complex phosphorylates and inactivates Bcl-2. Nat. Cell. Biol. 11:819-825.
57. Pacis RA, Pilat MJ, Pienta KJ, Wojno K, Raz A, Hogan V, Cooper CR. 2000. Decreased galectin-3 expression in prostate cancer. Prostate 2:118-23.
58. Perillo NL, Marcus ME, Baum LG. 1998. Galectins: Versatile modulators of cell adhesion, cell proliferation, and cell death. J. Mol. Med. 76:402-12.
59. Radkov SA, Kellam P, Boshoff C. 2000. The latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat. Med. 10:p. 1121-1127.
60. Renne R, Blackbourn D, Whitby D, Levy J, Ganem D. 1998. Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J. Virol. 72:5182-5188.
61. Schoeppner HL, Raz A, Ho SB, Bresalier RS. 1995. Expression of an endogenous galactose-binding lectin correlates with neoplastic progression in the colon. Cancer 12:2818-2826.
62. Saussez S, Camby I, Toubeau G, Kiss R. 2007. Galectins as modulators of tumor progression in head and neck squamous cell carcinomas. Head Neck 9:874-884.
63. Simonart T, Hermans P, Schandene L, Van Vooren JP. 2000. Phenotypic characteristics of Kaposi's sarcoma tumor cells derived from patch-, plaque-and nodular-stage lesions: Analysis of cell cultures isolated from AIDS and nonAIDS patients and review of the literature. Br. J. Dermatol. 143:557-563.
64. Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P, d'Agay MF, Clauvel JP, Raphael M, Degos L, et al. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86:1276-1280.
65. Staskus KA, Zhong W, Gebhard K, Herndier B, Wang H, Renne R, Beneke J, Pudney J, Anderson DJ, Ganem D, et al. 1997. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J. Virol. 71:715-719.
66. Thijssen VL, Hulsmans S, Griffioen AW. 2008. The galectin profile of the endothelium: Altered expression and localization in activated and tumor endothelial cells. Am. J. Pathol. 2:545-553.
67. Thome M, Schneider P, Hofmann K, Fickenscher H, Meini E, Neipel F, Mattmann C, Burns K, Bodmer JL, Schroter M, et al. 1997. Viral FLICEinhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 6624:517-521.
68. van Den Brule FA, Berchuck A, Bast RC, Liu FT, Gillet C, Sobel ME, Castronovo V. 1994. Differential expression of the 67-kD laminin receptor and 31-kD human laminin-binding protein in human ovarian carcinomas. Eur. J. Cancer 8:1096-1099.
69. van den Brule FA, Buicu C, Berchuck A, Bast RC, Deprez M, Liu FT, Cooper DN, Pieters C, Sobel ME, Castronovo V. 1996. Expression of the 67-kD laminin receptor, galectin-1, and galectin-3 in advanced human uterine adenocarcinoma. Hum. Pathol. 11:1185-1191.
70. van den Brule F, Califice S, Castronovo V. 2004. Expression of galectins in cancer: A critical review. Glycoconj. J. 19:537-542.
71. Xu XC, Xu XC, el-Naggar AK, Lotan R. 1995. Differential expression of galectin-3 in thyroid tumors: Potential diagnostic implications. Am. J. Pathol. 3:815-822.