Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 298, Issue 6, 2010, Pages

  Koike, Kengo ^a   Kondo, Yoshitaka ^b   Sekiya, Mitsuaki ^a   Sato, Yasunori ^c   Tobino, Kazunori ^a   Iwakami, Shin Iciro ^d   Goto, Sataro ^d   Takahashi, Kazuhisa ^a   Maruyama, Naoki ^b   Seyama, Kuniaki ^a   Ishigami, Akihito ^b,c  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c TOHO UNIVERSITY   (Japan)

^d JUNTENDO UNIVERSITY   (Japan)

Author keywords

Chronic obstructive pulmonary disease; Collagen

Indexed keywords

ASCORBIC ACID; COLLAGEN TYPE 1; MESSENGER RNA; PROTEIN P30; REACTIVE OXYGEN METABOLITE; REGUCALCIN; SIRTUIN 1; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASCORBIC ACID DEFICIENCY; COLLAGEN DEGRADATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DISEASE MARKER; DRUG EFFECT; DRUG MECHANISM; ELASTIC FIBER; ENZYME ACTIVITY; KNOCKOUT MOUSE; LUNG DEVELOPMENT; LUNG EMPHYSEMA; LUNG LAVAGE; MORPHOMETRICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; RISK FACTOR; SENESCENCE; VITAMIN INTAKE; WEANING; WILD TYPE;

ANIMALS; ASCORBIC ACID; ASCORBIC ACID DEFICIENCY; CALCIUM-BINDING PROTEINS; COLLAGEN TYPE I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; PULMONARY EMPHYSEMA; REACTIVE OXYGEN SPECIES; SIRTUIN 1;

EID: 77952779760     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00256.2009     Document Type: Article

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