Chlamydophila pneumoniae enhances secretion of VEGF, TGF-β and TIMP-1 from human bronchial epithelial cells under Th2 dominant microenvironment

Allergy, Asthma and Immunology Research

Volumn 2, Issue 1, 2010, Pages 41-47

  Park, Chan Sun ^a   Kim, Tae Bum ^a   Moon, Keun Ae ^b   Bae, Yun Jeong ^a   Lee, Hee Ran ^b   Jang, Min Kyoung ^b   Moon, Hee Bom ^a   Cho, You Sook ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Asan Institute for Life Sciences   (South Korea)

Author keywords

Asthma; Chlamydophila pneumoniae; Epithelial cells; Tissue inhibitor of metalloproteinases; Transforming growth factor beta; Vascular endothelial growth factor A

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ARTICLE; ASTHMA; BACTERIAL STRAIN; BRONCHUS MUCOSA; CELL NUCLEUS INCLUSION BODY; CHLAMYDIAL PNEUMONIA; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MICROENVIRONMENT; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; PROTEIN SECRETION; TH1 CELL; TH2 CELL;

EID: 77952776081     PISSN: 20927355     EISSN: 20927363     Source Type: Journal    
DOI: 10.4168/aair.2010.2.1.41     Document Type: Article

References (31)

1. Grayston JT, Campbell LA, Kuo CC, Mordhorst CH, Saikku P, Thom DH, Wang SP. A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR. J Infect Dis 1990;161:618-625 (Pubitemid 20120216)
2. Kuo CC, Jackson LA, Campbell LA, Grayston JT. Chlamydia pneumoniae (TWAR). Clin Microbiol Rev 1995;8:451-461
3. Cook PJ, Davies P, Tunnicliffe W, Ayres JG, Honeybourne D, Wise R. Chlamydia pneumoniae and asthma. Thorax 1998;53:254-259
4. Falck G, Gnarpe J, Hansson L-O, Svardsudd K, Gnarpe H. Comparison of Individuals With and Without Specific IgA Antibodies to Chlamydia pneumoniae: Respiratory Morbidity and the Metabolic Syndrome. Chest 2002;122:1587-1593 (Pubitemid 35366068)
5. Von Hertzen L, Vasankari T, Liippo K, Wahlström E, Puolakkainen M. Chlamydia pneumoniae and Severity of Asthma. Scand J Infect Dis 2002;34:22-27
6. Betsou F, Sueur JM, Orfila J. Anti-Chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults. FEMS Immunol Med Microbiol 2003;35:107-111 (Pubitemid 36298931)
7. Miyashita N, Kubota Y, Nakajima M, Niki Y, Kawane H, Matsushima T. Chlamydia pneumoniae and exacerbations of asthma in adults. Ann Allergy Asthma Immunol 1998;80:405-409 (Pubitemid 28246772)
8. Esposito S, Blasi F, Arosio C, Fioravanti L, Fagetti L, Droghetti R, Tarsia P, Allegra L, Principi N. Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing. Eur Respir J 2000;16:1142-1146 (Pubitemid 32148131)
9. Hahn DL, Dodge RW, Golubjatnikov R. Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. JAMA 1991;266:225-230
10. Pasternack R, Huhtala H, Karjalainen J. Chlamydophila (Chlamydia) pneumoniae serology and asthma in adults: A longitudinal analysis. J Allergy Clin Immunol 2005;116:1123-1128 (Pubitemid 41571798)
11. ten Brinke A. Risk factors associated with irreversible airflow limitation in asthma. Curr Opin Allergy Clin Immunol 2008;8:63-69
12. Rödel J, Woytas M, Groh A, Schmidt KH, Hartmann M, Lehmann M, Straube E. Production of Basic Fibroblast Growth Factor and Interleukin 6 by Human Smooth Muscle Cells following Infection with Chlamydia pneumoniae. Infect Immun 2000;68:3635-3641 (Pubitemid 30340468)
13. Kol A, Bourcier T, Lichtman AH, Libby P. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. J Clin Invest 1999;103:571-577 (Pubitemid 29094058)
14. Kaukoranta-Tolvanen SSE, Teppo AM, Laitinen K, Saikku P, Linnavuori K, Leinonen M. Growth of Chlamydia pneumoniaein cultured human peripheral blood mononuclear cells and induction of a cytokine response. Microb Pathog 1996;21:215-221 (Pubitemid 26290572)
15. Byrne GI, Ojcius DM. Chlamydia and apoptosis: life and death decisions of an intracellular pathogen. Nat Rev Microbiol 2004;2:802-808
16. Caspar-Bauguil S, Puissant B, Nazzal D, Lefèvre JC, Thomsen M, Salvayre R, Benoist H. Chlamydia pneumoniae Induces Interleukin-10 Production that Down-Regulates Major Histocompatibility Complex Class I Expression. J Infect Dis 2000;182:1394-1401
17. Cho YS, Kim TB, Lee TH, Moon KA, Lee J, Kim YK, Lee KY, Moon HB. Chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor-α-dependent pathway. Clin Exp Allergy 2005;35:1625-1631 (Pubitemid 43919797)
18. Jahn HU, Krüll M, Wuppermann FN, Klucken AC, Rosseau S, Seybold J, Hegemann JH, Jantos CA, Suttorp N. Infection and activation of airway epithelial cells by Chlamydia pneumoniae. J Infect Dis 2000;182:1678-1687
19. Yang J, Hooper WC, Phillips DJ, Tondella ML, Talkington DF. Induction of Proinflammatory Cytokines in Human Lung Epithelial Cells during Chlamydia pneumoniae Infection. Infect Immun 2003;71:614-620 (Pubitemid 36150752)
20. Kim TB, Moon KA, Lee KY, Park CS, Bae YJ, Moon HB, Cho YS. Chlamydophila pneumoniae triggers release of CCL20 and vascular endothelial growth factor from human bronchial epithelial cells through enhanced intracellular oxidative stress and MAPK activation. J Clin Immunol 2009;29:629-636
21. Cho YS, Kim TB, Lee TH, Moon KA, Lee J, Kim YK, Lee KY, Moon HB. Chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor-α-dependent pathway. Clin Exp Allergy 2005;35:1625-1631 (Pubitemid 43919797)
22. Osborn L, Kunkel S, Nabel GJ. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci U S A 1989;86:2336-2340 (Pubitemid 19102503)
23. Jeffery PK. Remodeling and Inflammation of Bronchi in Asthma and Chronic Obstructive Pulmonary Disease. Proc Am Thorac Soc 2004;1:176-183
24. Beatty WL, Morrison RP, Byrne GI. Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol Rev 1994;58:686-699
25. Wen FQ, Liu X, Manda W, Terasaki Y, Kobayashi T, Abe S, Fang Q, Ertl R, Manouilova L, Rennard SI. TH2 Cytokine-enhanced and TGF-β-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-γ and corticosteroids. J Allergy Clin Immunol 2003;111:1307-1318
26. Kim YK, Oh SY, Jeon SG, Park HW, Lee SY, Chun EY, Bang B, Lee HS, Oh MH, Kim YS, Kim JH, Gho YS, Cho SH, Min KU, Kim YY, Zhu Z. Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma. J Immunol 2007;178:5375-5382
27. Magnan AO, Mély LG, Camilla CA, Badier MM, Montero-Julian FA, Guillot CM, Casano BB, Prato SJ, Fert V, Bongrand P, Vervloet D. Assessment of the Th1/Th2 Paradigm in Whole Blood in Atopy and Asthma. Increased IFN-γ-producing CD8+ T Cells in Asthma. Am J Respir Crit Care Med 2000;161:1790-1796
28. Bosse M, Chakir J, Rouabhia M, Boulet LP, Audette M, Laviolette M. Serum Matrix Metalloproteinase-9: Tissue Inhibitor of Metalloproteinase-1 Ratio Correlates with Steroid Responsiveness in Moderate to Severe Asthma. Am J Respir Crit Care Med 1999;159:596-602.
29. Matsumoto H, Niimi A, Takemura M, Ueda T, Minakuchi M, Tabuena R, Chin K, Mio T, Ito Y, Muro S, Hirai T, Morita S, Fukuhara S, Mishima M. Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma. Thorax 2005;60:277-281
30. Dechend R, Maass M, Gieffers J, Dietz R, Scheidereit C, Leutz A, Gulba DC. Chlamydia pneumoniae Infection of Vascular Smooth Muscle and Endothelial Cells Activates NF-κB and Induces Tissue Factor and PAI-1 Expression: A Potential Link to Accelerated Arteriosclerosis. Circulation 1999;100:1369-1373
31. Krüll M, Bockstaller P, Wuppermann FN, Klucken AC, Mühling J, Schmeck B, Seybold J, Walter C, Maass M, Rosseau S, Hegemann JH, Suttorp N, Hippenstiel S. Mechanisms of Chlamydophila pneumoniae-Mediated GM-CSF Release in Human Bronchial Epithelial Cells. Am J Respir Cell Mol Biol 2006;34:375-382