A model of the chemoreflex control of breathing in humans: Model parameters measurement

Respiration Physiology

Volumn 120, Issue 1, 2000, Pages 13-26

  Duffin, James ^a,b   Mohan, Ravi M ^a   Vasiliou, Paris ^a   Stephenson, Richard ^a,b   Mahamed, Safraaz ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Carbon dioxide, ventilatory response; Control of breathing, rebreathing, model; Mammals, humans; Pattern of breathing, rebreathing; Rebreathing, chemoreflex control

Indexed keywords

ADULT; AIR CONDITIONING; ARTICLE; BREATHING; BREATHING RATE; CARBON DIOXIDE TENSION; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MODEL; NORMAL HUMAN; PRIORITY JOURNAL; TECHNIQUE; TIDAL VOLUME;

ADOLESCENT; ADULT; BLOOD GAS ANALYSIS; CHEMORECEPTORS; FEMALE; HUMANS; MALE; MODELS, BIOLOGICAL; RESPIRATORY MECHANICS; TIDAL VOLUME;

EID: 0034163866     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(00)00095-5     Document Type: Article

References (26)

1. Bechbache R.R., Chow H.H.K., Duffin J., Orsini E.C. The effects of hypercapnia, hypoxia, exercise and anxiety on the pattern of breathing in man. J. Physiol. Lond. 293:1979;285-300.
2. Casey K., Duffin J., McAvoy G.V. The effect of exercise on the central-chemoreceptor threshold in man. J. Physiol. Lond. 383:1987;9-18.
3. Clark F.J., von Euler C. On the regulation of depth and rate of breathing. J. Physiol. Lond. 222:1972;267-295.
4. 2 and in arterial pH. Fishman A.P., Cherniack N.S., Widdicombe J.G. Handbook of Physiology. II:1986;475-528 American Physiological Society, Bethesda.
5. Dahan A., DeGoede J., Berkenbosch A., Olievier I.C. The influence of oxygen on the ventilatory response to carbon dioxide in man. J. Physiol. Lond. 428:1990;485-499.
6. Duffin J. A mathematical model of the chemoreflex control of ventilation. Respir. Physiol. 15:1972;277-301.
7. Duffin J., McAvoy G.V. The peripheral-chemoreceptor threshold to carbon dioxide in man. J. Physiol. Lond. 406:1988;15-26.
8. Fink B.R. Influence of cerebral activity in wakefulness on regulation of breathing. J. Appl. Physiol. 16:1961;15-20.
9. Gardner W.N. The relation between tidal volume and inspiratory and expiratory times during steady-state carbon dioxide inhalation in man. J. Physiol. Lond. 272:1977;591-611.
10. Gardner W.N. The pattern of breathing following step changes of alveolar partial pressures of carbon dioxide and oxygen in man. J. Physiol. Lond. 300:1980;55-73.
11. Grodins F.S., Buell J., Bart A.J. Mathematical analysis and digital simulation of the respiratory control system. J. Appl. Physiol. 22:1967;260-276.
12. Hey E.N., Lloyd B.B., Cunningham D.J.C., Jukes M.G.M., Bolton D.P.G. Effects of various respiratory stimuli on the depth and frequency of breathing in man. Respir. Physiol. 1:1966;193-205.
13. Honda Y. Respiratory and circulatory activities in carotid body-resected humans. J. Appl. Physiol. 73:1992;1-8.
14. Jennett S., Russell T., Warnock K.A. The duration of inspiration during changing states of ventilation in man. J. Physiol. Lond. 251:1974;54-55.
15. Khoo M.C.K., Gottschalk A., Pack A.I. Sleep-induced periodic breathing and apnea: a theoretical study. J. Appl. Physiol. 70:1991;2014-2024.
16. CO2 stimulus threshold for carotid chemoreceptors and breathing. Respir. Physiol. 34:1978;359-375.
17. Lloyd B.B., Cunningham D.J.C. A quantitative approach to the regulation of human respiration. Cunningham D.J.C., Lloyd B.B. The Regulation of Human Respiration. 1963;331-349 Blackwell, Oxford.
18. Lloyd B.B. The interactions between hypoxia and other ventilatory stimuli. Hatcher J.D., Jennings D.B. Proceedings of the International Symposium on Cardiovascular and Respiratory Effects of Hypoxia. 1966;146-165 Karger, Basel.
19. McGurk S.P., Blanksby B.A., Anderson M.J. The relationship of hypercapnic ventilatory responses to age, gender and athleticism. Sports Med. 19:1995;173-183.
20. Mohan R., Duffin J. The effect of hypoxia on the ventilatory response to carbon dioxide in man. Respir. Physiol. 108:1997;101-115.
21. Mohan R.M., Amara C.E., Vasiliou P., Corriveau E.P., Cunningham D.A., Duffin J. Chemoreflex model parameters measurement. Adv. Exp. Med. Biol. 450:1997;185-193.
22. Rafferty G.F., Gardner W.N. Control of the respiratory cycle in conscious humans. J. Appl. Physiol. 81:1996;1744-1753.
23. Rapanos T., Duffin J. The ventilatory response to hypoxia below the carbon dioxide threshold. Can. J. Appl. Physiol. 22:1997;23-36.
24. 2. Aust. Ann. Med. 16:1967;20-32.
25. Rebuck A.S., Rigg J.R.A., Saunders N.A. Respiratory frequency response to progressive isocapnic hypoxia. J. Physiol. Lond. 258:1976;19-31.
26. Torrance R.W. Prolegomena. Chemoreception upstream of transmitters. Adv. Exp. Med. Biol. 410:1996;13-38.