Cardiac 17O MRI: Toward direct quantification of myocardial oxygen consumption

Magnetic Resonance in Medicine

Volumn 63, Issue 6, 2010, Pages 1442-1447

  McCommis, Kyle S ^a   He, Xiang ^a   Abendschein, Dana R ^b   Gupte, Pradeep M ^c   Gropler, Robert J ^a   Zheng, Jie ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Rockland Technimed Ltd   (United States)

Author keywords

17O2; Metabolic imaging; MR; Myocardial oxygenation consumption; T 1 imaging

Indexed keywords

BLOOD; BRAIN; ELECTROCARDIOGRAPHY; METABOLISM; METABOLITES; OXYGENATION;

CEREBRAL OXYGENATION; CONSUMPTION RATES; METABOLIC IMAGING; MYOCARDIAL METABOLISMS; MYOCARDIAL OXYGENATION CONSUMPTION; OXYGEN CONSUMPTION; OXYGEN CONSUMPTION RATE; ^17O2;

OXYGEN;

CONTRAST MEDIUM; HEMOGLOBIN GLUTAMER 200; HEMOGLOBIN GLUTAMER 200 O 16; HEMOGLOBIN GLUTAMER 200 O 17; OXYGEN 17; UNCLASSIFIED DRUG; WATER; OXYGEN;

ANIMAL EXPERIMENT; ARTICLE; BOLUS INJECTION; BRAIN OXYGEN CONSUMPTION; CONTROLLED STUDY; DRUG MEGADOSE; ELECTROCARDIOGRAM; FEASIBILITY STUDY; HEART MUSCLE; HEART MUSCLE OXYGEN CONSUMPTION; IN VIVO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; QUANTITATIVE ANALYSIS; REST; ANIMAL; DOG; IMAGE QUALITY; INSTRUMENTATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; OXYGEN CONSUMPTION; PILOT STUDY; STANDARD;

ANIMALS; CONTRAST MEDIA; DOGS; INJECTIONS, INTRAVENOUS; MAGNETIC RESONANCE IMAGING; MYOCARDIUM; OXYGEN CONSUMPTION; OXYGEN ISOTOPES; PHANTOMS, IMAGING; PILOT PROJECTS; REFERENCE STANDARDS;

EID: 77952693889     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22382     Document Type: Article

References (18)

1. 11C] acetate in dynamic positron emission tomography. Circulation 1989;79:134-142.
2. Yamamoto Y, de Silva R, Rhodes CG, Iida H, Lammertsma AA, Jones T, Maseri A. Noninvasive quantification of regional myocardial metabolic rate of oxygen by 15O2 inhalation and positron emission tomography: experimental validation. Circulation 1996;94:808-816.
3. Zheng J, Wang J, Nolte M, Li D, Gropler RJ, Woodard PK. Dynamic estimation of the myocardial oxygen extraction ratio during dipyridamole stress by MRI: a preliminary study in canines. Magn Reson Med 2004;51:718-726. (Pubitemid 38420448)
4. McCommis KS, Zhang H, Herrero P, Gropler RJ, Zheng J. Feasibility study of myocardial perfusion and oxygenation by noncontrast MRI: comparison with PET study in a canine model. Magn Reson Imaging 2008;26:11-19. (Pubitemid 350299723)
5. 17O MRI. Neurol Res 1993;15:7-22.
6. 2 delivery system. Neuroimage 2004;22:611-618.
7. Meiboom S. NMR study of the proton transfer in water. J Chem Phys 1961;34:375-388.
8. Makela HI, Grohn OH, Kettunen MI, Kauppinen RA. Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions. Biochem Biophys Res Commun 2001;289:813-818.
9. 17O by proton T1rho dispersion imaging. J Magn Reson B 1995;108:276-279.
10. Witschey WR 2nd, Borthakur A, Elliott MA, Mellon E, Niyogi S, Wallman DJ, Wang C, Reddy R. Artifacts in T1 rho-weighted imaging: compensation for B(1) and B(0) field imperfections. J Magn Reson 2007;186:75-85. (Pubitemid 46635246)
11. Rogers WJ, Gupte PM, Piccione EA, Kramer CM, Vido DA, Reichek N. T2 imaging using O-17 for detection of viability in myocardial infarction. In: Proceedings of 8th Annual Meeting of International Society for Magnetic Resonance in Medicine, p 1309, 1999, Vancouver, BC, Canada.
12. 2 inhalation. J Cereb Blood Flow Metab 2004;24:840-848.
13. Vinnakota KC, Bassingthwaighte JB. Myocardial density and composition: a basis for calculating intracellular metabolite concentrations. Am J Physiol Heart Circ Physiol 2004;286:H1742-1749.
14. 11C]acetate. J Nucl Med 1997;38:459-466.
15. Wamberg S, Sandgaard NC, Bie P. Simultaneous determination of total body water and plasma volume in conscious dogs by the indicator dilution principle. J Nutr 2002;132:1711S-1713S. (Pubitemid 34602743)
16. Gronert GA, Michenfelder JD, Steen PA, Milde JH. Canine whole body and organ system tolerance during 24 hours deep pentobarbital anesthesia. Anesthesiology 1983;58:18-25.
17. Borthakur A, Charagundla SR, Wheaton A, Reddy R. T1rho-weighted MRI using a surface coil to transmit spin-lock pulses. J Magn Reson 2004;167:306-316.
18. Witschey WR, Borthakur A, Elliott MA, Fenty M, Sochor MA, Wang C, Reddy R. T1rho-prepared balanced gradient echo for rapid 3D T1rho MRI. J Magn Reson Imaging 2008;28:744-754.